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Solution conditions determine the relative importanceof nucleation…
www-vendruscolo.ch.cam.ac.uk/buell2014pnas.pdf26 Jun 2014: Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mu-. -
ar5000117 1..9
www-vendruscolo.ch.cam.ac.uk/obrien2014acr.pdf2 Jun 2014: The rate kA,i1 isan important quantity because it defines the average speed atwhich codon i is translated.The other relevant rates are those associated with the process. ... and genomic sequences. This information enables reasonableestimates of kA,i1, kFU -
Kinetic modelling indicates that fast-translating codons can…
www-vendruscolo.ch.cam.ac.uk/obrien2014nc.pdf8 Jan 2014: þXij1. kIU;jkUF;jDj. Yiljþ1. kA;l þ1kA;l þ1 þkIU;l þkUI;l þkUF;lDl. :. ð6Þ. ... determine the derivative in terms of kA,iþ1; weprovide the exact expression in Supplementary Eq. -
Cooperative Assembly of Hsp70 Subdomain Clusters
www-vendruscolo.ch.cam.ac.uk/wright2018b.pdf23 Sep 2018: 3 = ka/k, we could determine the elongation rateconstant to be approximately ⟨k+⟩ = 2.0 1.2 M. ... For the two-state fits, the imposed bounds were ka 0, K̃ 1, and 0 α 1 1018. -
ja407951x 1..10
www-vendruscolo.ch.cam.ac.uk/biedermann2013jacs.pdf4 Oct 2013: 14,15 Besides, the higher affinity of Phe-(Gly)2(Ka,ternary = 2 10. ... contribution for hostguest binding (Ka up to 106M1, ΔH up to 70 kJ mol1). -
Exploring the role of post‐translational modifications in regulating…
www-vendruscolo.ch.cam.ac.uk/elturk2018ps.pdf23 Sep 2018: Na DHbb (kcal/mol) –TDSb. c (kcal/mol) DGbd (kcal/mol) Ka (10. 7 M21)e Kd (1029 M)e. ... kona (106 M21 s21) koff. a (1023 s21) Ka (107 M21)b Kd (10. -
The codon information index: a quantitative measure of the…
www-vendruscolo.ch.cam.ac.uk/caniparoli2013jsm.pdf16 Jul 2013: where Ka is the number of codons encoding for the amino acid a, ns,a(ca) is the number of. ... times a spin s is associated to the codon ca of the amino acid a and Ns,a =Ka. -
pcbi.1002169 1..9
www-vendruscolo.ch.cam.ac.uk/fitzpatrick11pcb.pdf15 Jan 2012: Dill KA (1985) Theory for the folding and stability of globular proteins. -
JCB: Article The Rockefeller University Press $30.00J. Cell Biol. ...
www-vendruscolo.ch.cam.ac.uk/chambers12jcb.pdf14 Aug 2012: ka Aggregation of U 5 m3(n1)mol(n1)min1. n Power dependence of aggregation. ... Thus, we speculate. Table 2. Correlating changes in the parameters kf, ka, and n with outputs in the ADPr and ADPr+ models. -
pone.0072286 1..5
www-vendruscolo.ch.cam.ac.uk/waudby2013po.pdf4 Oct 2013: doi:10.1074/jbc.M109541200. 4. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT (1996) NACP, a. -
Understanding the frustration arising from thecompetition between…
www-vendruscolo.ch.cam.ac.uk/gianni2014pnas.pdf7 Oct 2014: Proc Natl Acad SciUSA 96(26):14854–14859. 18. Scott KA, Randles LG, Clarke J (2004) The folding of spectrin domains II: Phi-valueanalysis of R16. ... Nat Struct Biol 9(3):209–216. 35. Ozkan SB, Bahar I, Dill KA (2001) Transition states and the -
A PDZ domain recapitulates a unifying mechanism for protein ...
www-vendruscolo.ch.cam.ac.uk/gianni07.pdf21 Dec 2006: 96:14854 –14859.28. Scott KA, Randles LG, Clarke J (2004) J Mol Biol 344:207–211.29. -
(vendruscolo07cosb)
www-vendruscolo.ch.cam.ac.uk/vendruscolo07cosb.pdf24 Apr 2007: 56. Smith LJ, Bolin KA, Schwalbe H, MacArthur MW, Thornton JM,Dobson CM: Analysis of main chain torsion angles in proteins:prediction of NMR coupling constants for native and randomcoil conformations. -
C2PROT070165 536..550
www-vendruscolo.ch.cam.ac.uk/periole2007p.pdf25 Feb 2014: ment. Trends Biochem Sci 2000;25:331–339. 3. Dill KA, Chan HS. From Levinthal to pathways to funnels. -
pone.0085185 1..8
www-vendruscolo.ch.cam.ac.uk/abeln2014po.pdf18 Jan 2014: 21. Prabhu NV, Sharp Ka (2005) Heat capacity in proteins. Annu Rev Phys Chem. -
pcbi.1000458 1..7
www-vendruscolo.ch.cam.ac.uk/auer09ploscb.pdf30 Sep 2009: study. Curr Opin Biotech 18: 565–571.4. Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. -
pone.0087133 1..11
www-vendruscolo.ch.cam.ac.uk/toth2014po.pdf25 Feb 2014: Targeting the Intrinsically Disordered StructuralEnsemble of a-Synuclein by Small Molecules as aPotential Therapeutic Strategy for Parkinson’s DiseaseGergely Tóth1,4, Shyra J. Gardai4, Wagner Zago4, Carlos W. Bertoncini1,2, Nunilo Cremades1,. -
Characterization of the nucleation barriers forprotein aggregation…
www-vendruscolo.ch.cam.ac.uk/auer07hfspj.pdf20 Nov 2007: Conway, KA, Lee, SJ, Rochet, JC, Ding, TT, Williamson, RE, andLansbury, PT (2000). -
Scaling behaviour and rate-determining steps in filamentous…
www-vendruscolo.ch.cam.ac.uk/meisl2017cs.pdf15 Dec 2017: Primary nucleation Primary nsolution aaggregatioHere we trconstant ka coarse-ghowever, apre-brilla. Secondary processes/multiplication processes Secondaryproduce npresent. -
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril…
www-vendruscolo.ch.cam.ac.uk/iljina2017bmcb.pdf17 Sep 2017: RESEARCH ARTICLE Open Access. Nanobodies raised against monomericɑ-synuclein inhibit fibril formation anddestabilize toxic oligomeric speciesMarija Iljina1†, Liu Hong1,2, Mathew H. Horrocks1,3, Marthe H. Ludtmann4, Minee L. Choi4, Craig D. Hughes5
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