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23 Jan 2020: Search this website. Sir Aaron Klug. 11 August 1926 – 20 November 2018. ... Sir Aaron Klug. 11 August 1926 – 20 November 2018. Published on.

4 Sep 2020: Venki Ramakrishnan’s group has solved the structure of the protein complex formed when mRNA is being scanned to find the start codon, providing new understanding of the molecular mechanisms underpinning initiation of translation.

21 Oct 2020: Looking at the precise 3D arrangement of atoms within a protein helps us to understand how it can perform its functions. Radu Aricescu’s and Sjors Scheres’ groups have now been able to resolve individual atoms for the first time in a

2 Dec 2020: Human GPCRs are the targets of approximately 34% of all FDA-approved drugs. GPCRs in fungi could also be useful drug targets, but no structures of fungal GPCRs had been solved. Chris Tate’s group has now determined the first structure of a fungal

20 Jul 2020: Published on. 20 July, 2020. Diagram showing the reverse transcriptase structure (white) with nascent cDNA strand (red), XNA template (green) and regions critical for reverse transcription of XNA templates (blue and

28 Aug 2020: The brain contains an enormous number of connections, known as synapses. Their loss is associated with many disorders. Radu Aricescu’s group and collaborators in Japan and Germany have designed a molecule that restores synapses in animal disease

27 Nov 2020: Mitochondrial ribosomes are different from those in the cytoplasm of human cells and little is known about their quality control. Venki Ramakrishnan’s group has discovered a novel pathway to rescue stalled mitoribosomes and determined structures

21 Aug 2020: In total, the team monitored how well and how accurately replication was able to take place on 20,000 sequences. ... Every combination of short tandem repeat, with control sequences, was synthesized on microarrays (20,000 sequences) and assembled into

19 Aug 2020: Proteins embedded in the cellular membrane perform a wide variety of necessary tasks. Most are folded into complex shapes that pass back and forth across the membrane. Patrick Chitwood and Manu Hegde have discovered a new type of chaperone that

17 Sep 2020: and Sale, J.E.† (2014). Determinants of G quadruplex-mediated epigenetic instability in REV1-deficient cells EMBO Journal 33, 2507-20. ... Nature Biotechnology 20, 1129-1134. PMID:12379869.