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Robotic crystallisation: LMB plates
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/robot-nomenclature.html27 Sep 2022: PEG-Ion. Hampton Research. HR2-126. 48. Grid screen, conc. PEG 3350 = 20% w/v and various salts at 0.2 M (no buffers). -
In-person public engagement returns after lockdown - MRC Laboratory…
https://www2.mrc-lmb.cam.ac.uk/in-person-public-engagement-returns-after-lockdown/13 Apr 2022: In-person public engagement is returning after a long hiatus during the pandemic. LMB scientists took part in British Science Week with schools and at the Cambridge Festival.
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John Jarvis (1942 – 2022) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/john-jarvis-1942-2022/20 Sep 2022: Published on. 20 September, 2022. John Jarvis. John Jarvis, a former research assistant, who spent nearly 40 years at the LMB working alongside César Milstein, in the PNAC Division, died on
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Donald Caspar 1927 – 2021 - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/donald-caspar-1927-2021/7 Jan 2022: He would become a frequent scientific worker at the Lab over the next 20 years and remained a friend and scientific colleague to many. ... Exploring implications of the icosahedral virus symmetry he had discovered kept him returning to the LMB for the
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Curios of 60 years of the LMB - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/curios-of-60-years-of-the-lmb/30 Mar 2022: The models, made over 30 years apart, are remarkably similar in overall shape, but with the earlier one representing a 20 Ångstrom (low-resolution) structure and the later 2 Ångstrom
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Aaron Klug: A Scientific Retrospective - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/aaron-klug-a-scientific-retrospective/7 Jun 2022: honour. Aaron, Nobel Laureate, former Director of the LMB and former President of The Royal Society, died on 20. ... Tony Crowther: Sir Aaron Klug OM. 11 August 1926 – 20 November 2018.
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Fred Sanger (1918 - 2013) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/fred-sanger/6 Oct 2022: This method would shape the way that genomics and biomedicine were explored and was key to the Human Genome Project, the international collaboration to identify all the approximately
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Fred Sanger at the LMB - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-news/fred-sanger-at-the-lmb-2/6 Oct 2022: With the techniques available at the time a sequence with only four elements was much more difficult to solve than a sequence with 20 elements.
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Constructive Bio launched to build on synthetic biology breakthroughs …
https://www2.mrc-lmb.cam.ac.uk/constructive-bio-launched-to-build-on-synthetic-biology-breakthroughs/19 Aug 2022: Jason commented, “Over the last 20 years, we have created a cellular factory that we can reliably and predictably program to create new polymers.
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Pi-PEG Screen 1.5 disclaimer
https://www2.mrc-lmb.cam.ac.uk/screens2/pdf/LMB19.pdf28 Sep 2022: MME 8.55 % 1-19 PEG 300 25.65 % HEPES 75 mM 7.1 PEG 600 8.55 % 1-20 PEG 350 MME 25.65 % HEPES 75 mM 7.3 PEG ... 15 % 2-19 PEG 600 8.55 % HEPES 75 mM 7.1 PEG 300 42.9 % 2-20 PEG 1000 7.5 % HEPES 75 mM 7.3 PEG 350 MME -
Cryptochrome proteins are integral to maintain time within the…
https://www2.mrc-lmb.cam.ac.uk/cryptochrome-proteins-are-integral-to-maintain-time-within-the-brains-master-clock/20 Jan 2022: Published on. 20 January, 2022. A schematic showing the effect of CRY1 on the relationships between localisation and intracellular mobility of endogenous fluorescently tagged PER2 as well as circadian rhythmicity of ... This circadian rhythm is
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Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic…
https://www2.mrc-lmb.cam.ac.uk/mammalian-clock-gene-cryptochrome-1-is-crucial-to-suprachiasmatic-nucleus-timekeeping/31 Aug 2022: Circadian rhythms, which dominate our daily lives and are implicated in many health disorders, are governed by the suprachiasmatic nucleus (SCN) – a network of approximately 20,000 cells in the hypothalamus
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Identical structures of α-synuclein filaments from Parkinson’s…
https://www2.mrc-lmb.cam.ac.uk/identical-structures-of-%CE%B1-synuclein-filaments-from-parkinsons-disease-and-dementia-with-lewy-bodies/20 Sep 2022: Published on. 20 September, 2022. Cryo-EM reveals both neurodegenerative diseases possess identical Lewy fold structure.
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Clinical study reveals striking daily temperature variation in the…
https://www2.mrc-lmb.cam.ac.uk/clinical-study-reveals-striking-daily-temperature-variation-in-the-human-brain-that-predicts-survival-after-brain-injury/13 Jun 2022: To compare these data with healthy brains, the researchers recruited 40 healthy volunteers (20 males, 20 females, aged 20-40 years) for non-invasive brain thermometry. ... This finding was quite unexpected given the confined age range (20-40 years) of
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Integrin-mediated T helper 2 cell clustering revealed as key step and …
https://www2.mrc-lmb.cam.ac.uk/integrin-mediated-t-helper-2-cell-clustering-revealed-as-key-step-and-potential-therapeutic-target-in-allergic-immune-response/22 Dec 2022: Allergy and allergic asthma result from inappropriate immune reactions. According to the charity Allergy UK, allergic diseases affect 20% of the UK and world population. ... in the mouse genome (20,000) for their involvement in IL-13 production.
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Collaborative LMB study reveals S-shaped structure of Aβ42 filaments…
https://www2.mrc-lmb.cam.ac.uk/collaborative-lmb-study-reveals-s-shaped-structure-of-a%CE%B242-filaments-in-alzheimers-disease-and-other-neurodegenerative-diseases/20 Jan 2022: Published on. 20 January, 2022. A recent structural study led by Sjors Scheres, Michel Goedert and Benjamin Ryskeldi-Falcon’s groups at the LMB has used cryo-EM to detect two
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Coot Tutorial CCP4 Summer School 2021 October 19, 2022 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial.pdf19 Oct 2022: 20. Coot’s Go To Atom Window (it doesn’t look exactly like this any more). • -
Donald Caspar (1927 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/donald-caspar-1927-2021/5 Jan 2022: He would become a frequent scientific worker at the Lab over the next 20 years and remained a friend and scientific colleague to many. ... Exploring implications of the icosahedral virus symmetry I had discovered kept me returning to the MRC Lab for the
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Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: struction, using local averaging to combine the three-dimensional data from multiplesubsets (17, 20). ... IUCrJ 4,393–399 (2017). 20. A. Miyazawa, Y. Fujiyoshi, M. Stowell, N. -
PNAS202120006_proof
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/pnas%20Lee%202022.pdf18 Dec 2022: S2A). ABC-typeATPases bound to ADP.BeF3 often represent the enzyme–substrate complex (20). ... The peak fractionswere concentrated using a Vivaspin 20 100,000-Da centrifugal concentrator andfrozen.
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