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Mammalian clock gene Cryptochrome 1 is crucial to suprachiasmatic…
https://www2.mrc-lmb.cam.ac.uk/mammalian-clock-gene-cryptochrome-1-is-crucial-to-suprachiasmatic-nucleus-timekeeping/31 Aug 2022: Circadian rhythms, which dominate our daily lives and are implicated in many health disorders, are governed by the suprachiasmatic nucleus (SCN) – a network of approximately 20,000 cells in the hypothalamus -
Identical structures of α-synuclein filaments from Parkinson’s…
https://www2.mrc-lmb.cam.ac.uk/identical-structures-of-%CE%B1-synuclein-filaments-from-parkinsons-disease-and-dementia-with-lewy-bodies/20 Sep 2022: Published on. 20 September, 2022. Cryo-EM reveals both neurodegenerative diseases possess identical Lewy fold structure. -
Clinical study reveals striking daily temperature variation in the…
https://www2.mrc-lmb.cam.ac.uk/clinical-study-reveals-striking-daily-temperature-variation-in-the-human-brain-that-predicts-survival-after-brain-injury/13 Jun 2022: To compare these data with healthy brains, the researchers recruited 40 healthy volunteers (20 males, 20 females, aged 20-40 years) for non-invasive brain thermometry. ... This finding was quite unexpected given the confined age range (20-40 years) of -
Integrin-mediated T helper 2 cell clustering revealed as key step and …
https://www2.mrc-lmb.cam.ac.uk/integrin-mediated-t-helper-2-cell-clustering-revealed-as-key-step-and-potential-therapeutic-target-in-allergic-immune-response/22 Dec 2022: Allergy and allergic asthma result from inappropriate immune reactions. According to the charity Allergy UK, allergic diseases affect 20% of the UK and world population. ... in the mouse genome (20,000) for their involvement in IL-13 production. -
Collaborative LMB study reveals S-shaped structure of Aβ42 filaments…
https://www2.mrc-lmb.cam.ac.uk/collaborative-lmb-study-reveals-s-shaped-structure-of-a%CE%B242-filaments-in-alzheimers-disease-and-other-neurodegenerative-diseases/20 Jan 2022: Published on. 20 January, 2022. A recent structural study led by Sjors Scheres, Michel Goedert and Benjamin Ryskeldi-Falcon’s groups at the LMB has used cryo-EM to detect two -
Coot Tutorial CCP4 Summer School 2021 October 19, 2022 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/tutorial/tutorial.pdf19 Oct 2022: 20. Coot’s Go To Atom Window (it doesn’t look exactly like this any more). • -
Donald Caspar (1927 – 2021) - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/about-lmb/lmb-alumni/alumni/donald-caspar-1927-2021/5 Jan 2022: He would become a frequent scientific worker at the Lab over the next 20 years and remained a friend and scientific colleague to many. ... Exploring implications of the icosahedral virus symmetry I had discovered kept me returning to the MRC Lab for the -
Structure of a cholinergic cell membraneNigel Unwina,1 Edited by ...
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/pnasS22.pdf4 Nov 2022: struction, using local averaging to combine the three-dimensional data from multiplesubsets (17, 20). ... IUCrJ 4,393–399 (2017). 20. A. Miyazawa, Y. Fujiyoshi, M. Stowell, N. -
PNAS202120006_proof
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/pnas%20Lee%202022.pdf18 Dec 2022: S2A). ABC-typeATPases bound to ADP.BeF3 often represent the enzyme–substrate complex (20). ... The peak fractionswere concentrated using a Vivaspin 20 100,000-Da centrifugal concentrator andfrozen. -
Asgard archaea shed light on the evolutionary origins of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf13 Jun 2022: Supplementary Fig. 1). These proteins act in sequence to bind,deform and cut membranes during membrane trafficking2–5, celldivision19,20, viral egress21,22 and in other important topologicallysimilar membrane remodelling events ... 150. 50. 250. mAU.
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