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2 Dec 2020: Human GPCRs are the targets of approximately 34% of all FDA-approved drugs. GPCRs in fungi could also be useful drug targets, but no structures of fungal GPCRs had been solved. Chris Tate’s group has now determined the first structure of a fungal

15 Jul 2020: Ana Tufegdzic Vidakovic joins as a new Group Leader in the PNAC Division, where she will continue her work on regulation of transcription in the context of DNA damage.

28 Aug 2020: The brain contains an enormous number of connections, known as synapses. Their loss is associated with many disorders. Radu Aricescu’s group and collaborators in Japan and Germany have designed a molecule that restores synapses in animal disease

27 Nov 2020: Mitochondrial ribosomes are different from those in the cytoplasm of human cells and little is known about their quality control. Venki Ramakrishnan’s group has discovered a novel pathway to rescue stalled mitoribosomes and determined structures

19 Aug 2020: Proteins embedded in the cellular membrane perform a wide variety of necessary tasks. Most are folded into complex shapes that pass back and forth across the membrane. Patrick Chitwood and Manu Hegde have discovered a new type of chaperone that

17 Sep 2020: and Sale, J.E.† (2014). Determinants of G quadruplex-mediated epigenetic instability in REV1-deficient cells EMBO Journal 33, 2507-20. ... Nature Biotechnology 20, 1129-1134. PMID:12379869.

3 Jun 2020: New research suggests that DNA building blocks may have coexisted with RNA at the dawn of life

14 Jul 2020: Although Jan’s group has been working on SMC complexes for about 20 years, it has been hard to even understand what they do with DNA in cells and determining the

14 Apr 2020: Between them, Nathan, Xiaohan, and Jennifer took part in more than 20 live chats and answered more than 60 questions outside the live chats.

12 Jun 2020: The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides various nutrients. Madeline Lancaster’s group have now developed a new brain organoid that produces CSF and has the potential to predict whether