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The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: 20 minutes for the purposes of imaging (typically 1-2 times in a lifetime). ... This will only be experienced by a minority of mice on the moderate protocols (less than 20%). -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: The total number of transplants performed also fell, ranging from a 3% decline for pancreas transplants to 20% for lung or heart-lung transplants. -
Neurobehavioural Mechanisms Underlying Mood, Anxiety and…
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf30 Apr 2024: The maximum number of shocks in an animal's lifetime would be 20, which would allow us to assess the effect of prior trauma on subsequent learning about adverse events. -
Remodelling of stem cells and niche cells from development and…
https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf30 Apr 2024: PPL number: | Granted: 20 Jun 22 | Amended: 18 Oct 23 | Expires: 20 Jun 27. ... However, as indicated above,. PPL number: | Granted: 20 Jun 22 | Amended: 18 Oct 23 | Expires: 20 Jun 27. -
Epigenetic inheritence and the control of developmental and…
https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf30 Apr 2024: For example, Angelman syndrome, an imprinting disorder leading to severe intellectual disability affects 1 in 12,000-1 in 20,000 people worldwide, and Prader-Willi syndrome, another imprinting disorder linked -
Potent monoclonal antibodies for biologics discovery (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf30 Apr 2024: Lung cancer – 1.8 million new patients/year, Breast cancer - 2.1 million new patients/year), Cardiovascular Metabolic and Renal diseases (which account for 20 million deaths/year), and in Respiratory -
The development of novel therapies (including cell and gene based…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf30 Apr 2024: 1. An estimated 20% of mice of strain NSG will show swelling around the hocks. ... Approximately 20% of all animals are expected to develop a neurodegenerative phenotype reaching moderate severity. -
Neuronal circuit mechanisms underlying cognitive memory judgements…
https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf30 Apr 2024: Downloaded: 9:38pm, 25 Apr 2024 Page 6 of 17. too small as they weigh only 20-30 g. ... Mice weigh only 20-30 g, so mice are too small for the implants that can weigh about 10 g. -
Understanding the roles of autophagy and related pathways in…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_roles_of_autophagy_and_related_pathways_in_proteinopathies_non-technical_summary_redacted.pdf30 Apr 2024: Species and numbers of animals expected to be used. Mice: 20,000. ... We have completed successful studies using sample sizes of approximately 20 animals per treatment group using behavioural approaches to assess disease progression against wild-type or -
The diversity of glia in health, development and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: Sub-threshold: 25%. Mild: 50%. Moderate: 20%. Severe: 5%. What will happen to animals at the end of this project?
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