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In vivo compressive forces (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf30 Apr 2024: We estimate that carrying out this work in culture will reduce our anticipated animal usage by roughly 20%. ... We will maintain 20 existing transgenic lines and two wild type lines and generate ten new transgenic lines (80x32 lines=2560 fish). -
Embryonic origins of heart disease
https://www.ubs.admin.cam.ac.uk/system/files/public/embryonic_origins_of_heart_disease_non-technical_summary_redacted.pdf29 Apr 2024: at day 20 out of 21-day incubation period). The majority of the studies will be ex vivo (after death), i.e. ... it decreases fetal body weight by 20% by the end of the incubation period. -
Molecular mechanisms of tolerance and immunosuppression…
https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf30 Apr 2024: PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28. ... A retrospective assessment of these aims will be due by 20 October 2028. -
Platelets as a therapeutic tool
https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf30 Apr 2024: Animals that have a loss of body weight of 20% relative to the baseline will be killed by a Schedule 1 method. ... altered bowel movements. Weight loss 10-20% of control animals. 3. Marked increase in body temperature, respiration noisy, comatose OR -
Models of mitochondrial diseases, pathogenesis and therapy
https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf30 Apr 2024: The remaining 20% will be neonates (new born pups up to weaning - approx. ... Animals experiencing Moderate severity will be closely monitored for weight loss (to gauge the impact of the abnormal movement on their ability to feed) and will be killed -
Proteotoxicity in development and ageing (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf30 Apr 2024: Mice:. 1) Mild 60%. 2) Sub-threshold 20%. 3) Moderate 20%. What will happen to animals at the end of this project? -
Understanding the cell biology behind cardiovascular diseases…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf30 Apr 2024: Route Daily vol. ml/kg Max. No./day Max. No. of doses. oral gavage 20 ml/kg 2 30. ... intraperitoneal 20 ml/kg 1 30. intravenous 10 ml/kg 1 14. intramuscular 10–50 µl 1 6. -
Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: The total number of substance administration through all these different routes will typically be 20 and in rare cases up to 60 over a minimum of 50 days. -
Understanding Infection Pathogenesis to Guide Therapies…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf30 Apr 2024: We have been running these infection models for the last 20 years and during that time we have generated thousands of data points in wild type mice in normal conditions. -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months. ... The incision will be closed with sutures. The surgical procedure is expected to take approximately 20 minutes.
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