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Early life origins of heart disease in mammals (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_life_origins_of_heart_disease_in_mammals_non-technical_summary_redacted.pdf30 Apr 2024: This will contribute. PPL number: | Granted: 20 Apr 23 | Expires: 20 Apr 28. ... Under terminal or recoverable anaesthesia, an animal at the. PPL number: | Granted: 20 Apr 23 | Expires: 20 Apr 28. -
Gut hormone modulation of metabolism (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/gut_hormone_modulation_of_metabolism_non-technical_summary_redacted.pdf30 Apr 2024: A minority of mice will undergo surgery aimed to interfere with known neuronal pathways connecting the intestine with the central nervous system performed under general anaethesia and typically lasting 10-20 -
Development of Live Bacterial Therapeutics to treat diseases with…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf29 Apr 2024: This will be closely monitored (twice a day or more if necessary) and when it exceeds predefined thresholds of either maximal weight loss of 20% or diarrhoea for 48 hours the ... Mild - 20%. Moderate - 80%. PPL number: | Granted: 29 Sep 22 | Amended: 18 -
Developing new mulivalent recombinant vaccines platforms against…
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf29 Apr 2024: We expect to take forwards about 10% of these (20 candidates) for further immunogenicity and functional studies that will involve approximately 150 mice per candidate vaccine. -
Discovery and development of treatments for immunological diseases
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf29 Apr 2024: dermatitis. For example rheumatoid arthritis, which is an autoimmune disease resulting in painful swollen joints and loss of movement, affected nearly 20 million people worldwide in 2017 (Safiri 2019) with more -
Mouse developmental genetics to study neurodevelopment and disease…
https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf30 Apr 2024: Species Severity Percentage. Mouse Mild 80%. Mouse Moderate 20%. Mouse Severe 0%. -
The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: 20 minutes for the purposes of imaging (typically 1-2 times in a lifetime). ... This will only be experienced by a minority of mice on the moderate protocols (less than 20%). -
Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …
https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf30 Apr 2024: The total number of transplants performed also fell, ranging from a 3% decline for pancreas transplants to 20% for lung or heart-lung transplants. -
Neurobehavioural Mechanisms Underlying Mood, Anxiety and…
https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf30 Apr 2024: The maximum number of shocks in an animal's lifetime would be 20, which would allow us to assess the effect of prior trauma on subsequent learning about adverse events. -
Remodelling of stem cells and niche cells from development and…
https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf30 Apr 2024: PPL number: | Granted: 20 Jun 22 | Amended: 18 Oct 23 | Expires: 20 Jun 27. ... However, as indicated above,. PPL number: | Granted: 20 Jun 22 | Amended: 18 Oct 23 | Expires: 20 Jun 27.
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