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Nutrient sensing in the brain
https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf30 Apr 2024: The total number of substance administration through all these different routes will typically be 20 and in rare cases up to 60 over a minimum of 50 days. -
Understanding Infection Pathogenesis to Guide Therapies…
https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf30 Apr 2024: We have been running these infection models for the last 20 years and during that time we have generated thousands of data points in wild type mice in normal conditions. -
New treatments for renal and liver disease (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months. ... The incision will be closed with sutures. The surgical procedure is expected to take approximately 20 minutes. -
Metabolic basis of microglia function in development (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf30 Apr 2024: A retrospective assessment of these aims will be due by 20 January 2029. ... Killed. A retrospective assessment of these predicted harms will be due by 20 January 2029. -
Early life origins of heart disease in mammals (non-technical…
https://www.ubs.admin.cam.ac.uk/system/files/public/early_life_origins_of_heart_disease_in_mammals_non-technical_summary_redacted.pdf30 Apr 2024: This will contribute. PPL number: | Granted: 20 Apr 23 | Expires: 20 Apr 28. ... Under terminal or recoverable anaesthesia, an animal at the. PPL number: | Granted: 20 Apr 23 | Expires: 20 Apr 28. -
Gut hormone modulation of metabolism (non-technical summary)_Redacted
https://www.ubs.admin.cam.ac.uk/system/files/public/gut_hormone_modulation_of_metabolism_non-technical_summary_redacted.pdf30 Apr 2024: A minority of mice will undergo surgery aimed to interfere with known neuronal pathways connecting the intestine with the central nervous system performed under general anaethesia and typically lasting 10-20 -
Development of Live Bacterial Therapeutics to treat diseases with…
https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf29 Apr 2024: This will be closely monitored (twice a day or more if necessary) and when it exceeds predefined thresholds of either maximal weight loss of 20% or diarrhoea for 48 hours the ... Mild - 20%. Moderate - 80%. PPL number: | Granted: 29 Sep 22 | Amended: 18 -
Developing new mulivalent recombinant vaccines platforms against…
https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf29 Apr 2024: We expect to take forwards about 10% of these (20 candidates) for further immunogenicity and functional studies that will involve approximately 150 mice per candidate vaccine. -
Discovery and development of treatments for immunological diseases
https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf29 Apr 2024: dermatitis. For example rheumatoid arthritis, which is an autoimmune disease resulting in painful swollen joints and loss of movement, affected nearly 20 million people worldwide in 2017 (Safiri 2019) with more -
The development of in vivo expressed biologics as a platform for…
https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf30 Apr 2024: 20 minutes for the purposes of imaging (typically 1-2 times in a lifetime). ... This will only be experienced by a minority of mice on the moderate protocols (less than 20%).
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