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Membrane Protein Insertion at the Endoplasmic Reticulum
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/75_Shao_S_Ann_Rev_2011.pdf9 Nov 2011: For insertion into the ER, the “ideal”TMD is a 20 residue α-helix composed ofnonpolar, mostly hydrophobic side chains. ... 1996,Heinrich et al. 2000). With further synthesis ofat least 20 residues beyond the TMD, it wouldhave the potential freedom
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