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36 March 2015 Physics Today www.physicstoday.org Over the past ...
www-vendruscolo.ch.cam.ac.uk/knowles2015pt.pdf1 Mar 2015: 12.). 200 nm. Figure 1. Amyloid fibrils formed from peptide fragments of transthyretin, a protein associated withseveral misfolding diseases. -
A molecular chaperone breaks the catalytic cycle that generates toxic …
www-vendruscolo.ch.cam.ac.uk/cohen2015nsmb-aop.pdf21 Feb 2015: 3.5 200 µV. 100 nM kainate (control)ba. 50 nM monomeric Aβ42100 nM kainate. ... gel filtration on a 3.4 cm 200 cm gel-filtration column at 4 C. -
©20 15N atu re A mer ica, Inc. All ...
www-vendruscolo.ch.cam.ac.uk/galvagnion2015ncb-inpress.pdf10 Feb 2015: 3. 0. 4. 2. 6. 8. 10. 12. 14. 190 200 210 220 230 240 2500 5 10 15 20. ... 0. 200. 400. 600. 800. 1,000. 0 10 20 30 40 50. -
The inverted free energy landscape of an intrinsically disordered…
www-vendruscolo.ch.cam.ac.uk/granata2015sr.pdf28 Nov 2015: F. B 0. MER. 200 220 240wavelength (nm). -10000. MER. MRE WavelengthTemperature (C). ... mn. (ht. gnel. eva. W202. 200. 198. 196. 0 20 40 60 80 100. -
bi-2015-00459r 1..10
www-vendruscolo.ch.cam.ac.uk/aprile2015b.pdf10 Aug 2015: The far-UV CD spectra of all the variants wererecorded from 200 to 250 nm at 25 C, and the spectrum of thebuffer was systematically subtracted from the spectra of allprotein ... or presence of a 1:200(Hsp70:Aβ42) molar ratio of the chaperone variants. -
Rational design of antibodies targeting specificepitopes within…
www-vendruscolo.ch.cam.ac.uk/sormanni2015pnas.pdf10 Aug 2015: We found that the median number is 200, and themean is 570 (Fig. -
NMR characterization of the conformational fluctuations of the human…
www-vendruscolo.ch.cam.ac.uk/leung2014ps.pdf1 Mar 2015: were calculated from Monte Carlo simulations using. 200 randomly distributed synthetic datasets.36 The. ... of 200,000-fold higher affinity. -
bi5b00670 1..11
www-vendruscolo.ch.cam.ac.uk/newby2015b.pdf28 Nov 2015: Aβ40 was thenadded (2535 μL in 10 mM NaOH) to give a final buffercomposition identical to that of the isotropic samples and afinal volume of 200 μL. ... RDCs at an ionic strength of 200 mM and found thatsystematic errors were reduced (Q = 0.13 with -
elifesciences.org De Simone et al. eLife 2015;4:e02777. DOI:…
www-vendruscolo.ch.cam.ac.uk/desimone2015elife.pdf10 Feb 2015: Protein concentrations were in the range of 200–350 μM. For the measurements of the bound state, N,N′,N"-triacetylchitotriose (triNAG) sugar was purchased from Sigma and dissolved in water ... Serial dilutions (200 µM, 100 µM, 50 µM, 25 µM, and -
jp5021824 1..9
www-vendruscolo.ch.cam.ac.uk/camilloni2015jpcb.pdf3 Feb 2015: Thesystem was then evolved for further 200 ps at constanttemperature. After that, KΘ was further increased linearly from5000 to 15000 kJ/mol in 200 ps.
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