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2623.tif
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jcb90.pdf23 Jan 2012: glycine receptors (for recent reviews, see references 5, 7, 24, 33). -
740 Research Paper Calcium triggers calcineurin-dependent synaptic…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Marks_McMahon1998.pdf21 Mar 2003: Correspondence: Harvey T. McMahonE-mail: hmm@mrc-lmb.cam.ac.uk. Received: 3 March 1998Revised: 24 April 1998Accepted: 5 May 1998. ... synapse. Cell 1994, 79:717-727. 24. DeBello WM, Betz H, Augustine GJ: Synaptotagmin andneurotransmitter release. -
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: due to impaired ASNA1-mediated nuclear targeting.24 Though emerin staining showed apparently normal localization of the protein in our patients, it did reveal the characteristic abnormal nuclear morphology previously described ... J Cardiovasc Dev Dis. -
ANALYSIS Integrating molecular and network biologyto decode…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Schmid_Nature2007.pdf22 Aug 2007: 2a)7,8,23,24. 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. ... Nature Biotechnol. 24, 1270–1278(2006). 42. Smith, C. J., Grigorieff, N. & Pearse, B. -
Prokaryotic cytoskeletons: protein filaments organizing small cells
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nrmicro.2017.153.pdf18 Jan 2018: Nature Reviews Microbiology, (2018). doi:10.1038/nrmicro.2017.153 -
Features critical for membrane binding revealed by DivIVA crystal…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/emboj201099a.pdf20 May 2010: 21.7) 24.1 (ano. 14.1) 3.8 4.3 (ano. 2.5) 2.8. Phasing Se SAD Ta SAD MR I SAD MRNumber of sites 6 5 8Mean FOM -
The ER membrane protein complex promotes biogenesis of sterol-related …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/JCS_2019.pdf18 Jan 2019: At 24 h post transfection, cellswere treated with MG132 (5 µg/ml) or DMSO (vehicle control) for 8 h andanalysed by flow cytometry. -
The current approach to initial crystallization screening of proteins …
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Gorrec_undersamplid_2013.pdf14 May 2013: Appl. Cryst. 24, 409–411.Kimber, M. S., Vallee, F., Houston, S., Necakov, A., Skarina, T., Evdokimova,. -
doi:10.1016/j.molcel.2006.06.019
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Ftsk%20mc%202006.pdf12 Aug 2006: with a FEI F20 microscope at 62,0003 magnification with 24 to 25. -
Insight 1 Dec McMahon NS
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/NatureReview2005.pdf4 Jan 2006: EMBO J. 24, 1537–1545 (2005). 25. Cremona, O. et al. Essential role of phosphoinositide metabolism in synaptic vesiclerecycling. ... Structure of the Sec23/24-Sar1 pre-budding complexof the COPII vesicle coat. Nature 419, 271–277 (2002). -
Bb9e55.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Vallis_McMahon1999.pdf21 Mar 2003: J Biol Chem 1996, 271:27979-27982. 24. Liu JP, Yajima Y, Li H, Ackland S, Akita Y, Stewart J, et al.: Molecularinteractions between dynamin and G-protein beta gamma-subunits ... Cells were plated 24 h prior to trans-fection (day 0) at a density of 1.4 -
� Supplementary Figure 1 Bacterial dynamin-like protein (BDLP) from…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/nature%20BDLP%202006%20sup.pdf28 Sep 2006: J Mol Biol 229, 105-24 (1993). 31. Summers, M. L., Wallis, J. -
Biol. Chem., Vol. 381, pp. 993 – 999, September/October ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/BiolChem%20Helical%20Tubes.pdf13 Sep 2000: Cell Struct. Funct. 24,285 – 290. Lu, C.L., Stricker, J., and Erickson, H.P. ... EMBO J. 16, 5455 –5463. Received May 24, 2000; accepted July 14, 2000. -
IntroductionThe endosomal system functions as an internal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf17 Jan 2006: treatment. Results were normalised againstthe amount of CD8 reaching the TGN after 24 minutes in control-treated cells, and were expressed the s.e.m. ... 9A).Compared with control cells, suppression of SNX1 led to a54.57.8% reduction in the amount of anti -
The ER membrane protein complex is a transmembrane domain insertase
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017c.pdf27 Jan 2018: 24, 2533–2542 (2005).10. B. M. Abell et al., J. Biol. Chem. ... essentially as described in detail previously (24, 36–38) and summarized in brief below. -
x16412u141
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MaoAP180-2001.pdf17 Mar 2003: 3 246,217 67,191 99.5 (100) 24.0 (4.4) 6.4 (27.1)SeMet l3 (0.9712) 2.3 248,253 67,292 99.7 (100) 22.9 ... Neuron 24, 143–154. Schmid, S.L. (1997). Clathrin-coated vesicle formation and proteinsorting: an integrated process. -
Crystal Structures of Bacillus subtilis Lon Protease
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/londumanjmb2010.pdf20 Jul 2010: electron microscopy data show that negativelystained images of E. coli Lon particles appearhexameric,24 although surprisingly, electron cryo-microscopy images of S. -
Cambridge's largest ever M&A deals: the top 10 | Cambridge…
https://www2.mrc-lmb.cam.ac.uk/archive/articles/M_&_A_deal_Cabume.pdf22 Dec 2011: Cambridge's largest M&A deal until HP and Autonomy's £7.1bn deal. 24 August 2011 08:19. -
Protocol for dragonfly
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/PDF/Manuals/protocols_for_dragonfly.pdf13 Dec 2017: secMAXI 24 200 1.8 2 min 25 secMAXI 48 200 3 4 min 20 sec. -
articles Nucleotide-dependent conformational changes in dynamin:…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Stowell_McMahon1999.pdf30 Apr 1999: Results of in vitro experiments have revealed that dynamin isable to bind and tubulate lipid membranes in the absence of anyother accessory factors23,24. ... RECEIVED 24 FEBRUARY 1999; REVISED 12 MARCH 1999; ACCEPTED 12 MARCH 1999; PUBLISHED MAY 1999. -
doi:10.1016/j.jmb.2004.12.031
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/jmb05.pdf24 Jan 2005: doi:10.1016/j.jmb.2004.12.031 J. Mol. Biol. (xxxx) xx, 1–23. ARTICLE IN PRESS. Refined Structure of the Nicotinic AcetylcholineReceptor at 4 Å Resolution. Nigel Unwin. MRC Laboratory of MolecularBiology, Hills Road, CambridgeCB2 2QH, UK. -
LIGANDS Meetings ● Previously:– Developer → Users ● Now ...
https://www2.mrc-lmb.cam.ac.uk/coot/ligands/2016/emsley-ccp4-ligands-dec-2016.pdf9 Dec 2016: Slide 19. Slide 20. Slide 21. Slide 22. Slide 23. Slide 24. -
DOI: 10.1126/science.1135394 , 239 (2007); 317Science et al.Nabil…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17626883.pdf8 Dec 2007: Wymann, M. Zvelebil, M. Laffargue, Trends. Pharmacol. Sci. 24, 366 (2003).4. ... Chem. 276, 21544 (2001). 24. E. H. Walker, O. Perisic, C. -
15591370691369 1..30
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/elife_2019.pdf29 May 2019: doxycycline, then analyzed 24 hr later by fluorescent microscopy. Doxycycline withdrawal for 24 hr limited the amount of reporter mRNA in cells to. ... Figure 5D and Figure 5—figure supplement 1C). Only a 24 kD band matching the size of TMED. -
© 2005 Nature Publishing Group Endophilin and CtBP/BARS are ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndopohilinNature2005.pdf4 Jan 2006: Plant Mol. Biol. 26,211–-223 (1994). 24. Coleman, J. Characterization of Escherichia coli cells deficient in 1-acyl-sn-glycerol-3-phosphate acyltransferase activity. -
TTC5 mediates autoregulation of tubulin via mRNA degradation
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2019.pdf19 Nov 2019: another TTC5 function (22–24), because the effects were not rescued by two unrelated point mutants of TTC5 that perturb autoregulation by different mechanisms. ... Mol. Cell 8, 71–84 (2001). doi:10.1016/S1097-2765(01)00277-5 Medline. 24. X. Hu, R. -
Articleshttps://doi.org/10.1038/s41594-019-0196-z 1MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Burmann%202019%20NSMB.pdf4 Mar 2019: Cell 163, 1628–1640 (2015). 24. Bürmann, F. et al. Tuned SMC arms drive chromosomal loading of prokaryotic condensin. ... Curr. Biol. 21, 12–24 (2011). 27. Badrinarayanan, A., Reyes-Lamothe, R., Uphoff, S., Leake, M. -
Proc. Natl. Acad. Sci. USAVol. 94, pp. 9637–9642, September ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9275175.pdf20 Apr 2002: An initial model wasbuilt using the program O (24). Noncrystallographic symmetryrestrained positional and temperature factor refinement werecarried out with the program X-PLOR. ... S. (1993) Acta Crystallogr. D 49,. 129 –147.24. Jones, T. A., Zou, J.-Y. -
Refined Structure of (alpha)(beta)-Tubulin at 3.5 A Resolution
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/jmb%20tubulin%20refinement.pdf3 Nov 2001: 24,pp. 255-302, Plenum Press, New York. 26. Wolf, S. G., Nogales, E., Kikkawa, M., Gratzinger,D., Hirokawa, N. & ... S. (1968). RelativisticHartree-Fock X-ray and electron scattering factors.Acta Crystallog. sect. A, 24, 390-397. -
Contrasting Membrane Interaction Mechanisms of AP180N-terminal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Stahelin_cho2003.pdf16 Jul 2003: The coating of the L1 sensor chiphas been described in detail previously (23, 24). ... 3).On the other hand, the membrane dissociation step of periph-eral proteins can be slowed by short range specific interactionsand membrane penetration of hydrophobic -
Crystal Structure of the SMC Head Domain: An ABC ATPase with 900…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TmSMChd%20JMB%202001.pdf20 Feb 2001: J. Appl. Crystallog. 24, 946-950. Laskowski, R. A., Macarthur, M. W., Moss, D. -
Dynamin architecture—from monomer to polymer
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/dynaminreviewCOSBILow2010.pdf21 Oct 2010: J Mol Med 2010, 88:339-350. 24. Ramachandran R, Schmid SL: Real-time detection reveals thateffectors couple dynamin’s GTP-dependent conformationalchanges to the membrane. -
Coot: Model-building tools for Molecular Graphics
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/web/coot-nottingham-jan-2010.pdf7 Jan 2010: Slide 19. Slide 20. Slide 21. Slide 22. Slide 23. Slide 24. -
Using Coot for model building into EM maps:A tutorial ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/EM-Tutorial-Coot-PE.pdf8 Sep 2015: Aim for 24 rmsd. 4. Jiggle Fit. The model is too far outside the density for a simple rigid-body refinement to be suitable. -
No Job Name
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/vandenent2008ftsq.pdf4 Mar 2008: FtsQ is a bitopic membraneprotein of 31 kDa (Robinson et al., 1984), consisting of ashort cytoplasmic tail (residues 1–24), a transmembraneregion (25–49) and a periplasmic domain of approximately226 residues -
DOI: 10.1126/science.1184429 , 1638 (2010); 327Science et al.Simon…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20339072.pdf2 Aug 2010: 9, 1142 (2007).23. C. Liang et al., Nat. Cell Biol. 10, 776 (2008).24. ... 1), factorially manipulatedpredator access and soil fertility, and monitoredplant biomass and populations of the potentherbivore Aphis nerii (Aphididae, Hemiptera), aspecialist on -
REPORT◥ PROTEIN HOMEOSTASIS Mechanistic basis for a moleculartriage…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017.pdf19 Jan 2017: S5). This orthogonal system pro-duces homogeneous TA-chaperone complexesthat can be used for downstream functional as-says (24). ... 24. A. Mateja et al., Science 347, 1152–1155 (2015).25. S. M. -
DOI: 10.1126/science.1164346 , 509 (2009); 323Science et al.Jeanne…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Salje%20et%20al%20Science%202009.pdf23 Jan 2009: Supporting Online Materialwww.sciencemag.org/cgi/content/full/1164346/DC1Materials and MethodsFigs. S1 to S5References. 7 August 2008; accepted 24 November 2008Published online 18 December 2008;10.1126/science.1164346Include this -
©2009 EuropEan MolEcular Biology organization EMBo reports Vol 10 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/MittalEmbor2008240.pdf9 Dec 2008: Mol Cell 24: 643–652. lin cH, Macgurn Ja, chu t, Stefan cJ, Emr SD (2008) arrestin-related ubiquitin ligase adaptors regulate endocytosis and protein turnover at the cell surface. -
doi:10.1016/j.ceb.2004.06.009
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MillsMcMahonAp2Review.pdf23 Nov 2004: coatedvesicles. The COPII membrane-associated sec23/24 com-plex has an intrinsic curvature like that found in COPIIvesicles and thus by polymerisation this curvature will befavoured [36]. ... with Sec23/24p in vitro. Stabilises Sec23/24 complex and. -
Asgard archaea shed light on the evolutionary origins of the…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hatano%20Nat%20Comms%202022.pdf13 Jun 2022: Nature Communications, doi:10.1038/s41467-022-30656-2 -
LETTERS Structural basis for selective recognition of ESCRT-IIIby the …
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17928861.pdf8 Dec 2007: e. 0 40 60 80 100200.20. 0.22. 0.24. 0.26. 0.28. 0.30. ... EMBO J. 24,3658–3669 (2005). 18. Babst, M., Katzmann, D. J., Estepa-Sabal, E. -
doi:10.1016/j.str.2007.05.002
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/FCH02F-BARHenne07.pdf2 Jun 2007: Coomassie-stained gel. P, pellet; S, superna-. tant. At protein concentrations above 24 mM,. ... For cryocooling, crystals were transferred stepwise into the crystalliza-. tion condition supplemented with up to 24% glycerol. -
BIO CHEM ISTR Y Structure of the SARS-CoV-2 RNA-dependent ...
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/SARS%20polym%202021%20e2021946118.full.pdf29 Aug 2021: 1 2 3 4 5 6. 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24. ... 9, 2. 021. 24 and SI Appendix, Fig. S1B). The accumulation of shorter primer exten-sion intermediates at higher concentrations of favipiravir-RTP may indicatepremature replication -
Dissertation
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/AndyHuang.pdf6 Mar 2008: algorithm [24]. Redundant pixels on the skeleton are eliminated by thinning. ... skeleton algorithm [7, 24]. However, sometimes the binary worm body shape has an internal hole,. -
bic296a
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/EberthBJ4170371.pdf24 Jan 2009: Two fragments of 24 and 22 kDaremained stable after limited trypsin cleavage for 48 h (Figure 1C;Supplementary Figure S2A, at http://www.BiochemJ.org/bj/417/bj4170371add.htm). ... J. Biol. Chem.280, 6716–6720. 24 Longenecker, K. L., Zhang, B. L., -
3747_0_supp_7_1052456676
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/christian.pdf9 May 2003: 24. individual yellow and cyan emission intensities. The ratio faithfully reflects reciprocal. -
Paul EmsleyMRC Laboratory of Molecular Biology, Cambridge, UKJune…
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/Ligands-July-2015-v2.pdf16 Jul 2015: 108.00 model_angle: 122.80 sigma: 3.00 angle-devi 14.80 penalty-score: 24.34 angle O2 - C6 - C3 target: 108.00 model_angle: 122.76 sigma: 3.00 ... angle-devi 14.76 penalty-score: 24.19 angle C13 - C15 - C17 target: 120.00 model_angle: 133.33 sigma: 3.00 -
Supplementary Text & Figs
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Schmid_Nature2007Sup.pdf22 Aug 2007: auxilin, clathrin)23,24, (actin, clathrin)25,26. AP2 is seen to be present at the same time as. ... Proc. Natl. Acad. Sci. U. S. A. 103, 10265-10270 (2006). 24. -
Calcium-dependent Membrane Penetration Is a Hallmark of theC2 Domain…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9668093.pdf20 Apr 2002: THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273, No. 30, Issue of July 24, pp.
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