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  1. Results that match 1 of 2 words

  2. Tumour prevention by a single antibody domaintargeting the…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf
    22 Jul 2007: Fisher et al, 2001).Received: 24 January 2007; accepted: 9 May 2007; published online:14 June 2007. ... methane) and set in 24-well Cryschem plates (Hampton Research),with 400 ml of reservoir solution.
  3. 25 Structural studies of phosphoinositide 3-kinase-dependent traffi c …

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17233579_proof.pdf
    14 Jun 2007: This partially overlaps with the region of ubiquitin interacting with the UIMs of Vps27 and Hrs [24–26], eliminating the possibility of simultaneous interaction with the same monoubiquitinated cargo. ... and Zhang, M. (2005). EMBO J. 24, 3985–399546.
  4. Monitoring chaperone engagement of substratesin the endoplasmic…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/39_Snapp_EL_PNAS_2006.pdf
    21 Sep 2006: Importantly, when aconservative point mutation (Y108F) that disrupts lectin activity ofCrt (24) was introduced into Crt-GFP [to generate Crt(Y108F)-. ... Biol. Cell 6,. 1173–1184. 24. Kapoor, M., Ellgaard, L., Gopalakrishnapai, J., Schirra, C., Gemma, E
  5. Tyrosine Residues in Phospholipase C�2 Essential for the…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11606584.pdf
    20 Apr 2002: baculovirus expression of Src family kinases were madeby subcloning the cDNAs (24) encoding activated Src (Y527F Src),activated Fyn (Y531F Fyn), and activated Lck (Y525F Lck) into thebaculovirus transfer vector ... Some of the additional sites couldbe
  6. pnas201205508 15259..15264

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/22949682.pdf
    25 Nov 2012: JBiol Chem 283:31227–31236. 24. Burke JE, et al. (2008) Interaction of group IA phospholipase A2 with metal ions andphospholipid vesicles probed with deuterium exchange mass spectrometry.
  7. PII: S1097-2765(01)00372-0

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11684018.pdf
    20 Apr 2002: Negatively charged regions are shown in red and positively chargedin blue (ranging from 18 kT/e to 24 kT/e). ... Crystallogr.heavy-atom parameter refinement for multiple isomorphous re- 24, 946–950.placement and multiwavelength anomalous diffraction
  8. PII: S1534-5807(04)00100-5

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Johannes_DevCell2004.pdf
    22 Mar 2005: A–E) HeLa cells were transfected with myc-epsinR for 24 hr and stained for the indicated markers. ... Cell 50,(Roche). Immunofluorescence experiments were carried out 24 hr 453–463.after transfection, as described previously (Johannes et al., 1997).
  9. Structural insight into the ESCRT-I/-II link and itsrole in ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17215868.pdf
    14 Jun 2007: 0.24. 0.25. 0.26. 0.27. Ani. sotr. opy. Concentration (µM)0 1 2 3. ... 0.22. 0.24. 0.26. Ani. sotr. opy. Concentration (nM). A 28 nM.
  10. doi:10.1016/j.devcel.2004.09.003

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15469844.pdf
    1 Nov 2004: Multiplicity (last shell) 14.1 (14.1) 14.3 (14.2) 11.6 (11.6) 7.2 (7.2) 6.9 (3.9) 24.9 (24.0)I/ (last shell)
  11. x96411u107

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11136978.pdf
    1 Dec 2000: Crystal 1 50–3.2 146,371/23,318 100 (100) 0.11 21.8 (3.6)Crystal 23 50–3.0 270,093/24,791 82.4 (51.3) ... Merge 50–3.0 7405 6 24,273 1510 0.21 0.28 (5.4) 0.0093 Å 1.298 22.78.
  12. doi:10.1016/j.molcel.2004.08.004

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15350214.pdf
    24 Sep 2004: Protein atoms 4404 4164 4138Waters 265 324 259Rcrystd 20.2 19.9 22.6Rfreed (% data used) 24.1 (5) 24.3 (5) 26.7 (5)r.m.s.d. ... inosi-in 1 l sitting drops over reservoirs of 24-well plates (Hampton).
  13. Arginine 383 is a crucial residue in ABCG2 biogenesis

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/56_Polgar_O_BBA_2009.pdf
    13 Jun 2009: which clones #11and #24 exhibited the highest levels, though significantly lowercompared to the wild-type (Fig. ... Biol. Chem. 280 (2005) 36926–36934. [24] Y.F. Li, O. Polgar, M.
  14. nrm2162.indd

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17450176.pdf
    14 Jun 2007: in clathrin-coated 80–500-nm diameter microdomains that decorate the endosomal membrane21,23,24, although at least in macrophages and T cells HRS is also detected on tubulovesicular membranes that ... 24. HRS binds clathrin by a Leu-Ile-Ser-Phe-Asp
  15. M6_07079a2

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17038310.pdf
    12 Nov 2006: Crystals were visible after 24 h and grew to full size within one week. ... 1998) J Biol Chem. 273, 25987-25995 24. Zhang, J., Banfic, H., Straforini, F., Tosi, L., Volinia, S., and Rittenhouse, S.
  16. doi:10.1016/j.molcel.2008.05.027

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/FtsK%20MolCell%202008%20Lowe.pdf
    16 Aug 2008: Molecular Cell. Article. Molecular Mechanism of Sequence-DirectedDNA Loading and Translocation by FtsKJan Löwe,1, Antti Ellonen,2 Mark D. Allen,3 Claire Atkinson,2 David J. Sherratt,2 and Ian Grainge2,1MRC Laboratory of Molecular Biology, Hills
  17. Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf
    29 Aug 2021: Ruptor 24 (Omni International, Kennesaw, GA, USA) at. 2 ms1 for 30 s. ... Histology and immunohistology. The left lung lobes were fixed in formal saline for 24 h and.
  18. Cooperative Recruitment of Dynamin and BIN/Amphiphysin/Rvs (BAR)…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/JBC_Meinecke2013.pdf
    19 Mar 2013: nexin 9 (SNX9) (23, 24). It has a BAR and an SH3 domain thatbinds to dynamin.The involvement of BAR domain proteins in dynamin activ-. ... J. Biol. Chem. 278, 46772–46781. 24. Soulet, F., Yarar, D., Leonard, M., and Schmid, S.
  19. bst641-09a

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/19614567.pdf
    2 Aug 2010: In contrast with the class IA enzymes, the single class IBisotype, p110γ , associates with p101 [23] or the closely relatedp84–p87 regulatory subunits [24,25]; neither subunit has arecognizable domain organization ... The p84–p110γ heterodimer is
  20. ©20 10 N atur e A mer ica, Inc. ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/20081827.pdf
    2 Aug 2010: Impaired PI(3)K signaling results in severe defects of innate and adaptive immune responses, suggesting that targeting of this isoform would be a beneficial therapeutic strategy20,24. ... Biochem. Soc. Trans. 35, 245–249 (2007). 24. Ameriks, M.K. &
  21. cdf519 5057..5068

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12356722.pdf
    12 Oct 2002: Resolution (AÊ ) 2.0 2.0Observations/unique reections 83 922/24 307 84 280/24 356Completeness (last shell) % 93.6 (74.1) 93.7 (74.1)Rmerge. ... The supernatant was collected anddialysed against 50 mM TrisHCl pH 8.0 and 1.5 M urea for 16 h, andthen
  22. molcel4221mmc1

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/MolCell2012MipZ/mipz2012supp.pdf
    15 Mar 2012: For interaction analyses, cells were streaked onto MacConkey agar plates (Carl Roth, Germany) supplemented with 1 % maltose and incubated at 30C for 24 h.
  23. Membrane fusion is the process whereby two separate lipid ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf
    16 May 2008: Membrane fusion is the process whereby two separate lipid bilayers merge to become one. It is essential for communication between membrane-delineated comp-artments in all eukaryotic cells (FIG. 1). The best-studied process involving membrane fusion
  24. doi:10.1016/S1097-2765(03)00246-6

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/12887891.pdf
    5 Sep 2003: Babior, B.M. (1999). NADPH oxidase: an update. Blood 93, 1464–(1.3 nmol) of PKC-GST was incubated with 24 g (1.5 nmol) of His6-1476.Par6b. ... J. Biol. Chem. 276,Revised: May 2, 200321627–21631.Accepted: May 2, 2003. Published: July 24, 2003 Grizot, S
  25. A Ternary Metal Binding Site in the C2 Domain ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9062102.pdf
    20 Apr 2002: 1996)J.Biochem. 120, 671-676. Kraulis, P. J. (1991)J. Appl. Crystallogr. 24, 946-950.Lee, S.
  26. JOURNAL OF VIROLOGY, Feb. 2004, p. 2088–2099 Vol. 78, ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/27_Tremblay_P_JV_2004.pdf
    15 Jan 2004: PrP 22-24 was detected at 112 days and130 days using the cold PK digestion protocol (Fig. ... 5A, B,and D). Mutant HuPrP 22-24 was found in Tg69 mice at 200days of age (Fig.
  27. TH EJ OU RN AL OF CE LL BIO ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16785321.pdf
    12 Nov 2006: 1 B). All the complete sequences analyzed in Fig. 1 have between 20 and 24 continuous repeats.
  28. Cryo‐EM structure of the MinCD copolymeric filament from Pseudomonas…

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Szewczak-Harris_et_al-2019-FEBS_Letters.pdf
    22 Jul 2019: binds the conserved C-terminal tail domain of FtsZ. and, importantly, binds MinD [24,25]. ... Curr Biol. 18, 235–244.24 Cordell SC, Anderson RE and Lowe J (2001) Crystal.
  29. Structural Mapping of the Catalytic Mechanism for a…

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/9048554.pdf
    20 Apr 2002: 4.6)〈I/σ(I)〉b 24.1(5.1) 15.7(4.3) 20.6(4.4) 17.2(4.9).
  30. nature14896 493..505

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/95_Brown_A_Nature_2015.pdf
    19 Aug 2015: Nucleic Acids Res. 33, 6418–6425 (2005). 24. Wong, L. E., Li, Y., Pillay, S., Frolova, L. & ... Defocus values ranged from 21.1 to 25.9 mm for the UAA-eRF1(AAQ) dataset, 20.7 to 24.1 mm for the UAG-eRF1(AAQ) data set, and
  31. GB-9-7-229-Amos_9.qxd

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/gb-2008-9-7-229.pdf
    4 Aug 2008: The 32 nm spacing between RS1 and RS2 and the 24 nm spacing between RS2 and RS3 are indicated bydouble-headed arrows. ... J Parasitol 2007,9933::608-618. 24. Arenas-Mena C, Wong KS-Y, Arandi-Forosani N: CCiilliiaarryy bbaanndd
  32. 2077 741..748

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/21_Lingappa_VR_BioEssays_2002.pdf
    5 Jul 2002: Cell 1986;47:711– 719. 24. Liao S, Lin J, Do H, Johnson AE. ... Molec Biol Cell 1998;9:2681– 2697. Problems and paradigms. BioEssays 24.8 747.
  33. Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Oct-TF.pdf
    8 Oct 2018: Slide 22. Slide 23. Slide 24. Slide 25. Slide 26. Slide 27.
  34. THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1990 by The ...

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/1_Pewitt_EB_JBC_1990a.pdf
    29 Dec 2004: Vol. 265, No. 24, Issue of August 25, pp. 14364-14370,199O Printed in V. ... K eq was determined at 0 “C! while Kd was obtained at 24 “C.
  35. The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersinia …

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Mittal_JBC2010.pdf
    4 Oct 2010: The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersinia Is Activated by Eukaryotic Host Cell InositolHexakisphosphateSReceived for publication, March 24, 2010, and in revised form, April 23, 2010 Published, JBC Papers ... They are also the
  36. doi:10.1016/j.str.2008.06.010

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/18786397.pdf
    3 Sep 2008: Structure. Article. Structure and Disassembly of FilamentsFormed by the ESCRT-III Subunit Vps24Sara Ghazi-Tabatabai,1 Suraj Saksena,2 Judith M. Short,1 Ajaybabu V. Pobbati,1 Dmitry B. Veprintsev,1. R. Anthony Crowther,1 Scott D. Emr,2 Edward H.
  37. FtsA forms actin-like protofilaments

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276a.pdf
    27 Mar 2012: RefinementResolution (Å) 1.8 1.8No. of reflections 74 365 38 267Rwork/Rfree 0.21/0.24 0.19/0.23ModelProtein FtsA: A 7-27, 32-319, 328-390 B
  38. Quality and quantity control at the endoplasmic reticulum

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/65_Hegde_RS_COCB_2010.pdf
    7 Jun 2010: EMBO J 2005,24:149-159. 55. Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY:Hrd1p/Der3p is a membrane-anchored ubiquitin ligaserequired for ER-associated degradation. ... EMBO J 2005, 24:3917-3926. 57. Isaacson MK, Ploegh HL: Ubiquitination,
  39. The Hydrophobic Insertion Mechanism of Membrane Curvature Generation…

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/CampeloBioPJ2008.pdf
    13 Dec 2008: complexes (7,24,25) generate small vesicles. Narrow mem-. brane tubules are produced by proteins of the dynamin family.
  40. x96255u149

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/11090628.pdf
    20 Apr 2002: Molecular Cell, Vol. 6, 909–919, October, 2000, Copyright 2000 by Cell Press. Structural Determinants of Phosphoinositide3-Kinase Inhibition by Wortmannin, LY294002,Quercetin, Myricetin, and Staurosporine. for proteins such as protein kinase B
  41. plbi-04-09-03 1532..1548

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SchmidBetaPaper/BetaHub.pdf
    31 Aug 2006: alone [22–24]. ... A cluster ofhydrogen-bonds in the peptide is consistent with the a-helical conformation in this region.(E) Density map for the peptide contoured at 1.24 r.DOI:
  42. Substrate-specific regulation of the ribosome–translocon junction by…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/17_Rutkowski_DT_PNAS_2001.pdf
    22 Jun 2001: Consistent withprevious studies (4, 10) when only 24 mature amino acids (maa)beyond the signal sequence have been synthesized, pPrl has not. ... Zheng, T. & Nicchitta, C. V. (1999) J. Biol. Chem. 274, 36623–36630.24.
  43. Model-Building with Modern Coot Paul Emsley Scripps, Feb 2019 ...

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/Coot-Scripps-Feb-2019-EOS.pdf
    21 Feb 2019: Slide 23. Slide 24. Slide 25. Slide 26. Alpha Helix Placement.
  44. A substrate-specific inhibitor of proteintranslocation into the…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/35_Garrison_JL_Nature_2005.pdf
    15 Jul 2005: b, Cells were transfected as in a, except that cotransin wasremoved from the medium after 24 h. ... Compounds were added 1 h before stimulation and were present during the entire 24 hstimulation period.
  45. Target Selection during Protein Quality Control

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/96_Shao_S_TIBS_2016.pdf
    18 Feb 2016: By contrast, the GTPase activity of Hbs1, although reliant on Dom34and the ribosome, appears impervious to the presence or identity of the mRNA within the A site[21,22,24,25].
  46. The structural basis of novel endosome anchoringactivity of KIF16B ...

    https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17641687.pdf
    23 Jul 2007: The structural basis of novel endosome anchoringactivity of KIF16B kinesin. Nichole R Blatner1, Michael I Wilson2,Cai Lei3, Wanjin Hong3, Diana Murray4,Roger L Williams2 and Wonhwa Cho 1,1Department of Chemistry, University of Illinois at Chicago,
  47. 16001658465475 1..36

    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Collier_2020_elife-59560-v1.pdf
    15 Sep 2020: For correspondence:. jyl@mrc-lmb.cam.ac.uk (JL);. ashley.nasmyth@bioch.ox.ac.uk. (KAN). †These authors contributed. equally to this work. Competing interests: The. authors declare that no. competing interests exist. Funding: See page 33. Received:
  48. Interactive Tools forCryo-EM Map Fitting Paul EmsleyMRC Laboratory of …

    https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-June-PSI.pdf
    19 Jun 2018: Slide 19. Slide 20. Slide 21. Slide 22. Slide 23. Slide 24.
  49. A Conserved Archaeal Pathway for TailAnchored Membrane Protein…

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/70_Sherrill_J_Traffic_2011.pdf
    11 Nov 2011: EMBOJ 2005;24:2533 – 2542. 19. Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariap-pan M, Hegde RS, Keenan RJ.
  50. Abstract_Book_HMM_v2

    https://www2.mrc-lmb.cam.ac.uk/groups/hmm/conferences/JM_Abstract_Book.pdf
    15 Sep 2011: p. 121. - 5 -. PROGRAMME. - 7-. Saturday, Sept. 24 Sunday, Sept. ... Meresse. 21:30 P. Greer 21:50 M.A. del Pozo. - 9 -. Saturday, September 24 Samedi 24 septembre. CNRS – Hotel Gulf Stream 16:00-20:00 Arrival and Registration Arrivée et
  51. No Job Name

    https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/49_MacKinnon_AL_JACS_2007.pdf
    30 May 2008: indicated concentrations. After 24 h, cells were harvested in lysis buffer (1% SDS, 0.1 M. ... 0.1 M) at 0 ºC was added LiOHH2O powder (24.1 mg, 0.573 mmol) and the reaction was.

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