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Model-Building with Modern Coot Paul Emsley Scripps, Feb 2019 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/Coot-Scripps-Feb-2019-EOS.pdf21 Feb 2019: Slide 23. Slide 24. Slide 25. Slide 26. Alpha Helix Placement. -
Activation of GCN2 by the ribosomal P-stalk
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/PNAS_2019.pdf7 Mar 2019: Yeast GCN2 forms aconstitutive dimer even in the absence of activation, principallythrough the CTD (24, 25). ... This lack of clarity was further con-founded by a more recent report that, unlike yeast, mouseGCN2 does not form a stable complex that -
Current Developments in Coot for Macromolecular Model Building…
https://www2.mrc-lmb.cam.ac.uk/coot/protein-science/Casanal_Lohkamp_Emsley_11112019-pe-2.pdf11 Nov 2019: by mmdb 24. The detected mutations, deletions and insertions are then applied as. ... Acta Crystallogr D Struct Biol 74:519–530. 24. Krissinel EB, Winn MD, Ballard CC, Ashton AW, Patel P, Potterton EA, McNicholas SJ, Cowtan KD, Emsley P (2004) The new -
Mechanism of ribosome stalling during translation of a poly(A) tail
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/NSMB_2019.pdf25 Nov 2019: The stalled ribosome triggers the ‘no-go’ or ‘nonstop’ pathways of mRNA decay10,13,17,18, nascent protein degra-dation via ribosome-associated quality control12,19–23 and ribosome ... 24,25,30,31). A second mechanism involves detecting the -
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: due to impaired ASNA1-mediated nuclear targeting.24 Though emerin staining showed apparently normal localization of the protein in our patients, it did reveal the characteristic abnormal nuclear morphology previously described ... J Cardiovasc Dev Dis. -
Cryo‐EM structure of the MinCD copolymeric filament from Pseudomonas…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Szewczak-Harris_et_al-2019-FEBS_Letters.pdf22 Jul 2019: binds the conserved C-terminal tail domain of FtsZ. and, importantly, binds MinD [24,25]. ... Curr Biol. 18, 235–244.24 Cordell SC, Anderson RE and Lowe J (2001) Crystal. -
The ER membrane protein complex promotes biogenesis of sterol-related …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/JCS_2019.pdf18 Jan 2019: At 24 h post transfection, cellswere treated with MG132 (5 µg/ml) or DMSO (vehicle control) for 8 h andanalysed by flow cytometry. -
Articleshttps://doi.org/10.1038/s41594-019-0196-z 1MRC Laboratory of…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Burmann%202019%20NSMB.pdf4 Mar 2019: Cell 163, 1628–1640 (2015). 24. Bürmann, F. et al. Tuned SMC arms drive chromosomal loading of prokaryotic condensin. ... Curr. Biol. 21, 12–24 (2011). 27. Badrinarayanan, A., Reyes-Lamothe, R., Uphoff, S., Leake, M. -
The structure of bactofilin filaments reveals their mode of membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Deng2019Natmicro.pdf26 Aug 2019: e (R. U). Time (s). WT. 0. 100. 200. 300. –1 10 14 24. -
TTC5 mediates autoregulation of tubulin via mRNA degradation
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2019.pdf19 Nov 2019: another TTC5 function (22–24), because the effects were not rescued by two unrelated point mutants of TTC5 that perturb autoregulation by different mechanisms. ... Mol. Cell 8, 71–84 (2001). doi:10.1016/S1097-2765(01)00277-5 Medline. 24. X. Hu, R.
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