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  2. Multi-tissue mechanics in the development and engineering of the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/multi-tissue_mechanics_in_the_development_and_engineering_of_the_posterior_body_axis_non-technical_redacted.pdf
    30 Apr 2024: Note that in this. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28. ... The number of. PPL number: | Granted: 24 Oct 23 | Expires: 24 Oct 28.
  3. Control of equine herpesviruses in the horse

    https://www.ubs.admin.cam.ac.uk/system/files/public/control_of_equine_herpesviruses_in_the_horse._non-technical_summary_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 07 Apr 22 | Amended: 11 Mar 24 | Expires: 07 Apr 27. ... The PPL holder will be required to disclose:. PPL number: | Granted: 07 Apr 22 | Amended: 11 Mar 24 | Expires: 07 Apr 27.
  4. Development of nerve neuroprosthetic treatment

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 04 Jul 22 | Amended: 13 Mar 24 | Expires: 04 Jul 27. ... Aim 2). PPL number: | Granted: 04 Jul 22 | Amended: 13 Mar 24 | Expires: 04 Jul 27.
  5. AWERB 3Rs Minutes 7th February 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_070224_redacted.pdf
    30 Apr 2024: Subject AWERB 3Rs Committee Our Ref Doc.AWERB.3Rs.07.02.24. AWERB 3Rs Committee :. In Attendance:. Minutes – Apologies:. 1. Minutes – 03/01/24. The minutes were approved.
  6. AWERB 3Rs Minutes 6th March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_060324_redacted.pdf
    1 May 2024: Subject AWERB 3Rs Committee Our Ref Doc.AWERB.3Rs 06.03.24. AWERB 3Rs Committee :. Minutes –. Apologies:. 1. MinutesThe minutes from the previous on 07/02/24 meeting were approved.
  7. AWERB 3Rs Minutes 3rd January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_030124_redacted.pdf
    30 Apr 2024: Subject AWERB 3Rs Committee Our Ref Doc.AWERB.3Rs.03.01.24. AWERB 3Rs Committee :. In attendance:. Minutes – Apologies:. 1. Minutes. The minutes of the meeting held on the 6th December
  8. AWERB Standing Minutes 24th January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_240124_redacted.pdf
    30 Apr 2024: Page 1 of 3. Minutes. Date Wednesday, 24/01/2024 Time 1pm. To Standing Committee At Virtual, MS Teams. ... Subject AWERB Standing Committee Our Ref Doc.UBS.AWERB.24.01.2024. In attendance:. Scientists in attendance for 1a) Core, 1b) Core & 1c) Core
  9. AWERB Standing Minutes 28th February 2024_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_280224_redacted.pdf
    30 Apr 2024: 4. Minutes of the AWERB sub-standing committee 10/01/24 The minutes were noted. ... 5. Minutes of the AWERB 3Rs Committee 03/01/24 The minutes were noted.
  10. AWERB Standing Minutes 27th March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_270324_redacted.pdf
    30 Apr 2024: 3. Minutes of last meeting 28/02/24 The minutes were approved. 4. ... 9. List items of note None Date of next meeting: 24/04/2024.
  11. Axon degeneration and repair (non-technical summary)

    https://www.ubs.admin.cam.ac.uk/system/files/public/axon_degeneration_and_repair_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 24 Apr 23 | Expires: 24 Apr 28.
  12. Cartilage repair and replacement

    https://www.ubs.admin.cam.ac.uk/system/files/public/cartilage_repair_and_replacement_non-technical_summary_redacted.pdf
    29 Apr 2024: Animals will also be individually housed (but within close proximity and line of sight to the rest of the 'flock') in the 24-48 hours prior to surgery. ... 4 or less). Followed by longer (e.g. 3, 6, 12 or 24 months), larger studies (less than 10 animals
  13. Nutrient sensing in the brain

    https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27. ... The PPL holder will be required to disclose:. PPL number: | Granted: 12 Jan 22 | Amended: 03 Feb 24 | Expires: 12 Jan 27.
  14. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28. ... Refinement. PPL number: | Granted: 25 Oct 23 | Amended: 29 Feb 24 | Expires: 25 Oct 28.
  15. In vivo compressive forces (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/in_vivo_compressive_forces_non-technical_summary_redacted.pdf
    30 Apr 2024: The neural crest cells are formed over approximately 24 hours. This means that we can put the intact embryo under a specialised microscope and can easily image the whole process of
  16. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: Tumour organoids do have more of. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29. ... Animals that enter experimental. PPL number: | Granted: 03 Jan 24 | Expires: 03 Jan 29.
  17. Proteotoxicity in development and ageing (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf
    30 Apr 2024: In summary, mice will be aged up to the age of 24 months. ... Some genetically altered mice will be maintained for ageing until they reach a maximum of 24 months of age.
  18. Molecular mechanisms of tolerance and immunosuppression…

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28. ... be. PPL number: | Granted: 20 Apr 23 | Amended: 24 Aug 23 | Expires: 20 Apr 28.
  19. Potent monoclonal antibodies for biologics discovery (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf
    30 Apr 2024: This can benefit a wider scientific community. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29. ... Mice. Mild Severity - 100%. Moderate severity - 0%. Rats. PPL number: | Granted: 08 Mar 24 | Expires: 08 Mar 29.
  20. Pharmacological evaluation of imaging agents and development of…

    https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf
    30 Apr 2024: Production of the candidate imaging agent. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29. ... Mice. Non-recovery: 64%. Mild: 36%. Moderate: 0%. Severe: 0%. Rats. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29.
  21. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: These animals will be killed unless there are signs of recovery within 24 hours.
  22. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: Mice that are immunised can show mild signs of discomfort that should last no more than 24 hours.
  23. Breeding and maintenance of rodents for drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf
    29 Apr 2024: Haem A, Haem B, and Glanzmann mice sometimes have surface bleeds that can be treated, and these usually resolve over 24 hours. ... Sometimes Haem A mice can have bleeds from the ears that also can, in most cases, resolve within 24 hours.
  24. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28. ... Reduction. PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28.
  25. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: This allows unsuitable drugs to be. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27. ... Blood samples are usually small in volume and are. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27.
  26. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 21 Mar 24 | Expires: 21 Mar 29. ... Over the period 24-96h, animals may show reduced appetite for food and water, which is expected to result in minor weight loss (less than 5-10% of their pre-operative
  27. Cancer and its microenvironment! From mechanisms to translation…

    https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28. ... lung. PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28.
  28. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: subcutaneous 20ml/kg 2 24. Exceptions to this would be thioglycollate IP, which needs to be given in 1ml (standard practice), and the HDTV injection.
  29. Development of humanised mouse models for study of cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf
    29 Apr 2024: In such cases, the animals will be culled if these clinical signs do not respond to treatment (such as high energy and easily digestible diet) and persist for up to 24
  30. Neurobehavioural Mechanisms Underlying Mood, Anxiety and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf
    30 Apr 2024: We have published these findings in animal welfare journals. However, 24% of animals will need to experience more than three shocks, with the maximum number of footshocks that will be delivered ... Moderate: 76%. Severe: 24%. What will happen to animals
  31. The genetic and developmental basis of morphological and behavioural…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf
    30 Apr 2024: Nonetheless, we will closely monitor the fish to detect any signs of suffering and stress during the procedure and in 24 hours following the procedure. ... This will require a maximum of 1800 animals. PPL number: | Granted: 29 Feb 24 | Expires: 28 Feb 29.
  32. Biobehavioural basis of the individual vunerability to impulsive…

    https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27. ... with. PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27.
  33. Generation and screening of companion animal therapeutics.…

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf
    30 Apr 2024: Companion animal immunoglobulin. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29. ... Substances will be. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29.
  34. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months.
  35. Development of Molecular Imaging and Theranostic Agents for Cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_molecular_imaging_and_theranostic_agents_for_cancer_and_inflammation_non-technical_s_redacted.pdf
    30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 5 of 9. subdued behaviour which persists for 24 h and cannot be ameliorated by minor veterinary interventions, will be humanely killed before the
  36. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Jul 23 | Expires: 03 Jul 28. Downloaded: 9:27pm, 25 Apr 2024 Page 2 of 11. Objectives and benefitsDescription of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing.
  37. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: Similarly, researchers found that there was a 24% increased risk of depression, which increased the number of depressed individuals from an average of 10/1,000 to 14/1,000 in ... Since this is an experimental modelling of a viral infection, the female
  38. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27. ... Ascites may occur. PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27.
  39. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: As the mice are checked daily, at most, a mouse would experience paralysis for no more than 24 hours.
  40. Neuronal circuit mechanisms underlying cognitive memory judgements…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf
    30 Apr 2024: A typical study lasts between 12-24 months during which time a marmoset may receive approx. ... Such effects typically resolve within 2 hours but can extend to approximately 24 hours.
  41. Investigating the niche of mucosal parasitic nematodes and their…

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf
    30 Apr 2024: 2) Labouring breathing on days 2-4 of hookworm infection, which resolves in 24 hours.
  42. Neural, physiological and behavioural mechanisms underlying cognition …

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_physiological_and_behavioural_mechanisms_underlying_cognition_and_emotion_non-technical_sum_redacted.pdf
    30 Apr 2024: A typical study lasts between 12-24 months during which time an animal may receive approx. ... Such effects typically resolve within 3 hours but can extend to approximately 24 hours.
  43. Remodelling of stem cells and niche cells from development and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf
    30 Apr 2024: Samples will be collected after humanely killing mice at different ages from birth and up to 24 months of age.
  44. Environmental and placental contributions to pregnancy and life-long…

    https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf
    29 Apr 2024: Any mouse displaying intermittent hunching or abnormal stance or reduced activity for a period of time not to exceed 24 hours, will be humanely killed. •

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