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  2. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: Mice that are immunised can show mild signs of discomfort that should last no more than 24 hours.
  3. PPL number: | Granted: 18 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_of_novel_antibodies_with_therapeutic_potential_nts_redacted.pdf
    20 Aug 2021: What's the aim of this project? PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24. ... Refinement. PPL number: | Granted: 18 Nov 19 | Expires: 18 Nov 24.
  4. PPL number: | Granted: 31 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/enteroendocrine_signalling_in_health_and_disease_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 31 Jan 19 | Amended: 16 Jul 21 | Expires: 30 Jan 24.
  5. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: These animals will be killed unless there are signs of recovery within 24 hours.
  6. Pharmacological evaluation of imaging agents and development of…

    https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf
    30 Apr 2024: Production of the candidate imaging agent. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29. ... Mice. Non-recovery: 64%. Mild: 36%. Moderate: 0%. Severe: 0%. Rats. PPL number: | Granted: 16 Feb 24 | Expires: 16 Feb 29.
  7. Breeding and maintenance of rodents for drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf
    29 Apr 2024: Haem A, Haem B, and Glanzmann mice sometimes have surface bleeds that can be treated, and these usually resolve over 24 hours. ... Sometimes Haem A mice can have bleeds from the ears that also can, in most cases, resolve within 24 hours.
  8. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: subcutaneous 20ml/kg 2 24. Exceptions to this would be thioglycollate IP, which needs to be given in 1ml (standard practice), and the HDTV injection.
  9. Biobehavioural basis of the individual vunerability to impulsive…

    https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_the_individual_vulnerability_to_impulsivecompulsive_spectrum_disorders_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27. ... with. PPL number: | Granted: 14 Jan 22 | Amended: 24 Jan 22 | Expires: 14 Jan 27.
  10. Cancer and its microenvironment! From mechanisms to translation…

    https://www.ubs.admin.cam.ac.uk/system/files/public/cancer_and_its_microenvironment_from_mechanisms_to_translation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28. ... lung. PPL number: | Granted: 25 Jan 23 | Amended: 24 Jan 24 | Expires: 25 Jan 28.
  11. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Jul 23 | Expires: 03 Jul 28. Downloaded: 9:27pm, 25 Apr 2024 Page 2 of 11. Objectives and benefitsDescription of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing.
  12. Neurobehavioural Mechanisms Underlying Mood, Anxiety and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf
    30 Apr 2024: We have published these findings in animal welfare journals. However, 24% of animals will need to experience more than three shocks, with the maximum number of footshocks that will be delivered ... Moderate: 76%. Severe: 24%. What will happen to animals
  13. Generation and screening of companion animal therapeutics.…

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_and_screening_of_companion_animal_therapeutics._non-technical_summary_redacted.pdf
    30 Apr 2024: Companion animal immunoglobulin. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29. ... Substances will be. PPL number: | Granted: 10 Apr 24 | Expires: 10 Apr 29.
  14. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28. ... Reduction. PPL number: | Granted: 18 Apr 23 | Amended: 28 Mar 24 | Expires: 18 Apr 28.
  15. AWERB Standing Minutes 24th January 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_240124_redacted.pdf
    30 Apr 2024: Page 1 of 3. Minutes. Date Wednesday, 24/01/2024 Time 1pm. To Standing Committee At Virtual, MS Teams. ... Subject AWERB Standing Committee Our Ref Doc.UBS.AWERB.24.01.2024. In attendance:. Scientists in attendance for 1a) Core, 1b) Core & 1c) Core
  16. PPL number: | Granted: 28 Oct 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_how_neutrophil_migration_behaviour_is_fine-tuned_during_inflammation_nts_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 28 Oct 19 | Expires: 28 Oct 24.
  17. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Even with timely dialysis, the death rates in patients with kidney failure vary from 20% to 50% over 24 months.
  18. Development of humanised mouse models for study of cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf
    29 Apr 2024: In such cases, the animals will be culled if these clinical signs do not respond to treatment (such as high energy and easily digestible diet) and persist for up to 24
  19. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: This allows unsuitable drugs to be. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27. ... Blood samples are usually small in volume and are. PPL number: | Granted: 24 Mar 22 | Expires: 24 Mar 27.
  20. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 21 Mar 24 | Expires: 21 Mar 29. ... Over the period 24-96h, animals may show reduced appetite for food and water, which is expected to result in minor weight loss (less than 5-10% of their pre-operative
  21. The genetic and developmental basis of morphological and behavioural…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf
    30 Apr 2024: Nonetheless, we will closely monitor the fish to detect any signs of suffering and stress during the procedure and in 24 hours following the procedure. ... This will require a maximum of 1800 animals. PPL number: | Granted: 29 Feb 24 | Expires: 28 Feb 29.
  22. PPL number: | Granted: 29 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatment_strategies_for_myocardial_infarction_and_aortic_aneurysm_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24. ... Contains severe proceduresRequired at inspector’s discretion. PPL number: | Granted: 29 Jan 19 | Amended: 03 Sep 21 | Expires: 28 Jan 24.
  23. PPL number: | Granted: 16 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf
    13 Sep 2021: If no improvement was shown within 24 hours, then the animal would be humanely killed.
  24. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: Similarly, researchers found that there was a 24% increased risk of depression, which increased the number of depressed individuals from an average of 10/1,000 to 14/1,000 in ... Since this is an experimental modelling of a viral infection, the female
  25. PPL number: | Granted: 20 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_basis_of_spatial_cognition_and_memory_in_the_hippocampus_nts_redacted.pdf
    20 Aug 2021: All surgical. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24. ... Reduction. PPL number: | Granted: 20 Nov 19 | Expires: 20 Nov 24.
  26. University of Cambridge AWERB Handbook Version 6.6 2nd March ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/02.03.2021_awerb_handbook_6.6_external.pdf
    3 Mar 2021: University of Cambridge AWERB Handbook Version 6.6 2nd March 2021. 0. Advice based on Animals (Scientific Procedures) Act 1986. As reviewed and transposed 1 January 2012 and Amended 1 January 2013. University Biomedical Services. Table of Contents.
  27. PPL number: | Granted: 01 Apr 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_new_devices_to_be_used_in_human_surgery_nts_redacted.pdf
    20 Aug 2021: For laparoscopic procedures:. Potential adverse effects. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24. ... By combining as. PPL number: | Granted: 01 Apr 21 | Expires: 01 Apr 24.
  28. Development of Molecular Imaging and Theranostic Agents for Cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_molecular_imaging_and_theranostic_agents_for_cancer_and_inflammation_non-technical_s_redacted.pdf
    30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 5 of 9. subdued behaviour which persists for 24 h and cannot be ameliorated by minor veterinary interventions, will be humanely killed before the
  29. PPL number: | Granted: 21 Jan 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_long-term_effects_of_developmental_hypoxia_on_cardiac_function_nts_redacted.pdf
    19 Aug 2021: 4. For moderate levels of prenatal hypoxia (below 13% oxygen), rats will first be put into the chamber at normal oxygen levels (21%) for 24 hours, and then oxygen will be ... reduced slowly (over another 24-hour period) to avoid shock.
  30. PPL number: | Granted: 10 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genetic_and_developmental_basis_of_morphological_variation_in_cichlid_fish_nts_expires2024_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 10 Apr 19 | Amended: 16 Jul 21 | Expires: 09 Apr 24.
  31. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: As the mice are checked daily, at most, a mouse would experience paralysis for no more than 24 hours.
  32. AWERB Standing Minutes 28th February 2024_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_280224_redacted.pdf
    30 Apr 2024: 4. Minutes of the AWERB sub-standing committee 10/01/24 The minutes were noted. ... 5. Minutes of the AWERB 3Rs Committee 03/01/24 The minutes were noted.
  33. Neuronal circuit mechanisms underlying cognitive memory judgements…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neuronal_circuit_mechanisms_underlying_cognitive_memory_judgements_non-technical_summary_redacted.pdf
    30 Apr 2024: A typical study lasts between 12-24 months during which time a marmoset may receive approx. ... Such effects typically resolve within 2 hours but can extend to approximately 24 hours.
  34. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_canc_redacted.pdf
    30 Apr 2024: PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27. ... Ascites may occur. PPL number: | Granted: 03 Feb 22 | Amended: 14 Mar 24 | Expires: 03 Feb 27.
  35. PPL number: | Granted: 19 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf
    20 Aug 2021: Theories and ideas can. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24. ... Page 8 of 11. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24.
  36. PPL number: | Granted: 18 Nov 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/papillomavirus_transmission_infection_and_lesion_formation_nts_redacted.pdf
    19 Aug 2021: The PV infection protocol (protocol 6) is estimated to require a maximum of 1000 mice (24 mice per experiment, for 50 experiments) over 5 years.
  37. PPL number: | Granted: 25 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/circuit_mechanisms_of_learning_and_memory_in_the_mammalian_brain_nts_expires2026_redacted.pdf
    13 Sep 2021: PPL number: | Granted: 25 Mar 21 | Amended: 24 Aug 21 | Expires: 25 Mar 26. ... Objectives and benefits. PPL number: | Granted: 25 Mar 21 | Amended: 24 Aug 21 | Expires: 25 Mar 26.
  38. PPL number: | Granted: 09 Sep 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_integrated_stress_response_in_respiratory_disease_nts_redacted.pdf
    13 Sep 2021: drug administration and will be monitored regularly for signs of adverse effects within 24 hours of administration, e.g. ... For blood sampling, no more than 10% of total blood volume in 24 hours and 15% of total blood volume in any 28 day period.
  39. Neural, physiological and behavioural mechanisms underlying cognition …

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_physiological_and_behavioural_mechanisms_underlying_cognition_and_emotion_non-technical_sum_redacted.pdf
    30 Apr 2024: A typical study lasts between 12-24 months during which time an animal may receive approx. ... Such effects typically resolve within 3 hours but can extend to approximately 24 hours.
  40. Investigating the niche of mucosal parasitic nematodes and their…

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf
    30 Apr 2024: 2) Labouring breathing on days 2-4 of hookworm infection, which resolves in 24 hours.
  41. PPL number: | Granted: 21 Aug 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_humoral_immunity_in_tissue-specific_immune_responses_in_health_and_disease_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 21 Aug 19 | Amended: 25 Nov 20 | Expires: 21 Aug 24. ... Species- Mouse. 10000 over 5 years. Predicted harms. PPL number: | Granted: 21 Aug 19 | Amended: 25 Nov 20 | Expires: 21 Aug 24.
  42. PPL number: | Granted: 05 May 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/safety_efficacy_and_immunogenicity_of_regenerative_cellular_therapies_redacted.pdf
    18 Jun 2021: In such cases, the animals will be culled if these clinical signs do not respond to treatment (such as high energy and easily digestible diet) and persist for up to 24
  43. AWERB Standing Minutes 27th March 2024

    https://www.ubs.admin.cam.ac.uk/system/files/public/awerb_standing_minutes_270324_redacted.pdf
    30 Apr 2024: 3. Minutes of last meeting 28/02/24 The minutes were approved. 4. ... 9. List items of note None Date of next meeting: 24/04/2024.
  44. PPL number: | Granted: 02 Feb 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/ageing_and_therapy_in_mouse_models_for_neurodegenerative_diseases_redacted_0.pdf
    18 Jun 2021: Animals undergoing surgical procedures will experience transient discomfort after surgery, however these animals will fully recover in less than 24 hours with no lasting effect on their general well being. ... Mild 70%. Moderate 24%. Severe 6%. PPL number
  45. Concordat on Openness on Animal Research in the UKAnnual ...

    https://www.ubs.admin.cam.ac.uk/sites/www.ubs.admin.cam.ac.uk/files/concordat-on-openness-annual-report-2023.pdf
    15 Nov 2023: Concordat on Openness on Animal Research in the UKAnnual Report 2023. H. Hobson and H. Ramchandani. Contents. Foreword 1. Executive summary 2. Introduction 10. About this report 18. PART 1: PROGRESS IN OPENNESS ON ANIMAL RESEARCH IN THE UK 20.
  46. Environmental and placental contributions to pregnancy and life-long…

    https://www.ubs.admin.cam.ac.uk/system/files/public/environmental_and_placental_contributions_to_pregnancy_and_life-long_health_non-technical_summary_redacted.pdf
    29 Apr 2024: Any mouse displaying intermittent hunching or abnormal stance or reduced activity for a period of time not to exceed 24 hours, will be humanely killed. •
  47. Remodelling of stem cells and niche cells from development and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/remodelling_of_stem_cells_and_niche_cells_from_development_and_regeneration_to_disease_non-technic_redacted.pdf
    30 Apr 2024: Samples will be collected after humanely killing mice at different ages from birth and up to 24 months of age.
  48. Development of nerve neuroprosthetic treatment

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf
    29 Apr 2024: PPL number: | Granted: 04 Jul 22 | Amended: 13 Mar 24 | Expires: 04 Jul 27. ... Aim 2). PPL number: | Granted: 04 Jul 22 | Amended: 13 Mar 24 | Expires: 04 Jul 27.
  49. PPL number: | Granted: 20 Nov 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/cell_competition_and_the_dynamics_of_tumour_development_in_epithelial_tissues_nts_redacted.pdf
    20 Aug 2021: PPL number: | Granted: 20 Nov 19 | Amended: 18 Dec 20 | Expires: 20 Nov 24. ... What's the aim of this project? PPL number: | Granted: 20 Nov 19 | Amended: 18 Dec 20 | Expires: 20 Nov 24.
  50. PPL number: | Granted: 02 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_regulation_of_fat_mass_and_its_association_with_metabolic_disease_redacted.pdf
    18 Jun 2021: Page 4 of 8. These mice would then be group housed in their home cages while being supplied with a regular diet or a high fat diet for 24 weeks.
  51. PPL number: | Granted: 12 Jun 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/biobehavioural_basis_of_vulnerability_to_impulsivecompulsive_spectrum_disorders_-_optimisation_and_redacted.pdf
    19 Aug 2021: humans, these signs wear off rapidly (within 24 to 48 hours). ... Thus, of all the 48 rats (24 from a standard condition, 24 from an enriched environment) trained to self-administer cocaine for over 80 days in this experiment, 6 became addicted

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