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80096 RPF
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/EMBO2012FtsAPiotr/emboj201276s3.pdf7 Mar 2012: were due to contamination? 24) Page 14, lines 15-17: Apart from the S. ... 24. Page 14, lines 15-17: Apart from the S. pneumoniae FtsA, a full length hypermorphic FtsA (FtsA) was purified from E. -
Protection from cytosolic prion protein toxicityby modulation of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/30_Rane_N_EMBO_2004.pdf8 Nov 2004: After 18–24 h, cells were harvested for parallelluciferase measurements (using a Luciferase Reporter Kit fromRoche) and immunoblotting. ... Biochemical analysesExperiments analyzing PrP constructs were performed between 18and 24 h after transfection -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Oct-TF.pdf8 Oct 2018: Slide 22. Slide 23. Slide 24. Slide 25. Slide 26. Slide 27. -
#¥1D
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/11_Hegde_RS_Science_1998.pdf3 Feb 1998: B) The F2 transgenic animals (n 5 24) were observedfor signs of neurodegenerative disease, including ataxia and paresis. ... To. ensure that vesicle integrity was maintainedduring the proteolysis reaction, we alsoevaluated the accessibility to protease -
A Conserved Archaeal Pathway for TailAnchored Membrane Protein…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/70_Sherrill_J_Traffic_2011.pdf11 Nov 2011: EMBOJ 2005;24:2533 – 2542. 19. Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariap-pan M, Hegde RS, Keenan RJ. -
No Job Name
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/49_MacKinnon_AL_JACS_2007.pdf30 May 2008: indicated concentrations. After 24 h, cells were harvested in lysis buffer (1% SDS, 0.1 M. ... 0.1 M) at 0 ºC was added LiOHH2O powder (24.1 mg, 0.573 mmol) and the reaction was. -
Current Developments in Coot for Macromolecular Model Building…
https://www2.mrc-lmb.cam.ac.uk/coot/protein-science/Casanal_Lohkamp_Emsley_11112019-pe-2.pdf11 Nov 2019: by mmdb 24. The detected mutations, deletions and insertions are then applied as. ... Acta Crystallogr D Struct Biol 74:519–530. 24. Krissinel EB, Winn MD, Ballard CC, Ashton AW, Patel P, Potterton EA, McNicholas SJ, Cowtan KD, Emsley P (2004) The new -
ARTICLES ; The structural basis of tail-anchoredmembrane protein…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/61_Mateja_A_Nature_2009.pdf3 Aug 2009: EMBO J. 24,270–282 (2005). 19. Hayashi, I., Oyama, T. & Morikawa, K. ... Cell 94, 181–191(1998). 24. Jiang, Y. et al. Nonequivalence of the nucleotide binding domains of the ArsAATPase. -
tra_578 1..18
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Burtey%20IVF%20Traffic%2007.pdf15 May 2007: Received 24 July 2006, revised and accepted for publica-tion 2 April 2007. ... residues 319–418), displayed a punctate distribution co-. localizing with clathrin (24), suggesting its constitutive. -
Journal of Lipid Research Volume 39, 1998 1287 Translocational ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/10_Rusinol_AE_JLR_1998.pdf30 May 1998: Nature. 365: 65–68. 24. Gordon, D. A., J. R. Wetterau, and R. ... J. Lipid Res. 24: 1243–1250. 33. Rouser, G., A. N. Siakatos, and S. -
A Ubiquitin Ligase-Associated Chaperone Holdase Maintains…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/72_Wang_Q_Mol_Cell_2011.pdf23 May 2012: Using. Molecular Cell. Bag6 Chaperones ERAD Substrates. Molecular Cell 42, 758–770, June 24, 2011 ª2011 Elsevier Inc. ... Molecular Cell. Bag6 Chaperones ERAD Substrates. Molecular Cell 42, 758–770, June 24, 2011 ª2011 Elsevier Inc. -
Model-Building with Modern Coot Paul Emsley Scripps, Feb 2019 ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/Coot-Scripps-Feb-2019-EOS.pdf21 Feb 2019: Slide 23. Slide 24. Slide 25. Slide 26. Alpha Helix Placement. -
Molecular Biology of the CellVol. 16, 279 –291, January ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/32_Levine_CG_MBC_2005.pdf21 Dec 2004: Between 5000 and 10,000 cells were plated per well of a 96-well platebetween 24 and 36 h before transfection, at which time they were 40 – 80%confluent. ... Unless other-wise noted in the figure legend, the cells were analyzed 18 –24 h after -
Molecular Biology of the CellVol. 21, 3054 –3069, September ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/RVS161_MBC2010.pdf21 Feb 2011: Molecular Biology of the CellVol. 21, 3054 –3069, September 1, 2010. Dissecting BAR Domain Function in the YeastAmphiphysins Rvs161 and Rvs167 during EndocytosisJi-Young Youn,‡ Helena Friesen,†‡ Takuma Kishimoto, William M. Henne,Christoph -
Transmembrane topogenesis of a tail-anchoredprotein is modulated by…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/36_Brambillasca_S_EMBO_2005.pdf20 Jul 2005: 2005 European Molecular Biology Organization The EMBO Journal VOL 24 | NO 14 | 2005. ... The EMBO Journal VOL 24 | NO 14 | 2005 & 2005 European Molecular Biology Organization2536. -
pgen.1004082 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/84_Chen_C_PlosGen_2014.pdf24 Sep 2015: Its tertiary structure is verysimilar to that of ubiquitin (Ub) although its primary sequenceshows no obvious sequence similarity to Ub [24]. -
70 88..91
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/97_Voorhees_RM_Science_2016.pdf5 Jan 2016: 24 September 2015; accepted 18 November 2015Published online 1 December 201510.1126/science.aad5227. ... Silhavy, EMBO J. 12, 3391–3398. (1993).24. A. P. Maillard, S. Lalani, F. -
Combinatorial Control of Prion Protein Biogenesis by the…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/18_Kim_SJ_JBC_2001.pdf26 Jun 2001: Second, mutations disrupting theh-region often severely impair the obligate targeting function ofa signal sequence (24). -
Volume 22 May 15, 2011 1625 Cytosolic aggregates perturb ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/69_Chakrabarti_O_MBC_2011.pdf11 Nov 2011: A major mature glycosylated species was repopulated over the course of 24 h (Figure 1C). ... PrP Prl-PrP CRFR1 Prl-CRFR1. 24 h 48 h 96 h 96 h 24 h 48 h 96 h 96 h. -
Interactive Tools forCryo-EM Map Fitting Paul EmsleyMRC Laboratory of …
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-June-PSI.pdf19 Jun 2018: Slide 19. Slide 20. Slide 21. Slide 22. Slide 23. Slide 24. -
Mechanism of signal sequence handover from NAC to SRP on ribosomes…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2022.pdf27 Feb 2022: S15), which suggests thatformation of the SRP•SR complex will displaceNAC from SRP at the ER membrane (22–24).The direct interaction of the UBA domain ofNAC with SRP raises questions ... Adv. 7, eabg0942 (2021).24. K. Kobayashi et al., Science 360, -
Asymmetric distribution of pause transfer sequences in apolipoprotein …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/6_Kivlen_MH_JLR_1997.pdf30 May 2008: Such functional intermediates can be studied and ma- nipulated much as has been done for various transloca- tion-associated events (7, 22-24). -
doi:10.1016/j.jmb.2005.02.053
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/34_Menetret_JF_JMB_2005.pdf6 Apr 2005: prolongedaccess to the cytoplasm21 and can be crosslinked tonascent chains.17,22–24 Sequence-based analysis hasidentified TRAP-related proteins in higher eukary-otes but not in budding yeast. ... In a previous map,connection C3 was observed as a weak -
Protein targeting and degradation are coupled for elimination of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/73_Hessa_T_Nature_2011.pdf14 Jul 2011: FEBS Lett. 582, 4143–4146 (2008). 24. Heck, J. W., Cheung, S. ... At 24 h after transfection, the cells were harvested in 1% SDS;. -
DOI: 10.1126/science.1229091, 1334 (2012);338 Science et al.P.…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/sciencegayathri2012/Science-2012-Gayathri-1334-7.pdf7 Dec 2012: Domain I residues were fitted by using Chimera(24). Real-space R-factors (RSR) against the map forParM:AMPPNP (E) and ParM:ParRpept (F) quantify thebest fit (movie S1 and fig. ... Supplementary -
Substrate-driven assembly of a translocon for multipass membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Nature_2022b.pdf19 Aug 2023: 24). Notably, the ribosome exit tunnel is offset from the central channel of Sec61 towards its back side (Fig. ... Biochem. Biophys. Res. Commun. 312, 850–857 (2003). 24. Sadlish, H., Pitonzo, D., Johnson, A. -
doi:10.1016/j.tibs.2009.03.001
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/58_Chakrabarti_O_TIBS_2009.pdf13 Jun 2009: Because PrPSc has a longer half-life (24 h) for lysosomaldegradation, it can accumulate to relatively high levels in intracellular compartments of the endo-lysosomal system. ... J. Biol.Chem. 278, 45960–45968. 24 Fons, R.D. et al. (2003) -
Ribosome-associated protein quality control
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/98_Brandman_O_NSMB_2016.pdf18 Feb 2016: Nature Structural & Molecular Biology 23, 7 (2016). doi:10.1038/nsmb.3147 -
Supplemental Materials Supp MethodsSupp Fig. 1 Sequence conservation…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004Sup.pdf23 Nov 2004: Transferrin uptake and immunofluorescenceCos 7 cells were transfected using GeneJuice according to manufacturers instructions,plated onto polylysine coated coverslips 24 hours post transfection and assayed fortransferrin uptake 48 hours post -
Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/PDF/Publications/acs.biochem.9b00296.pdf31 Jul 2019: leucine zipper motifs.24,25. -
Molecular Biology of the CellVol. 18, 3681–3691, September 2007 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/48_Rutkowski_DT_MBC_2007.pdf15 Aug 2007: Molecular Biology of the CellVol. 18, 3681–3691, September 2007. The Role of p58IPK in Protecting the Stressed EndoplasmicReticulumD. D. Thomas Rutkowski,† Sang-Wook Kang,†‡ Alan G. Goodman,Jennifer L. Garrison, Jack Taunton, Michael G. Katze -
The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Lundmark_McMahon_GRAF2008.pdf28 Nov 2008: Accepted: October 8, 2008. Published online: November 24, 2008. References. 1. -
16262551036386 1..32
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cohesin%20folding%202021%20elife-67268-v1.pdf14 Jul 2021: For correspondence:. jyl@mrc-lmb.cam.ac.uk (JL);. ashley.nasmyth@bioch.ox.ac.uk. (KAN). †These authors contributed. equally to this work. Competing interests: The. authors declare that no. competing interests exist. Funding: See page 28. Received: -
Evolving nature of the AP2 a-appendage hubduring clathrin-coated…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004.pdf23 Nov 2004: Evolving nature of the AP2 a-appendage hubduring clathrin-coated vesicle endocytosis. Gerrit JK Praefcke1,2, Marijn GJ Ford1,Eva M Schmid, Lene E Olesen,Jennifer L Gallop, Sew-Yeu Peak-Chew,Yvonne Vallis, M Madan Babu,Ian G Mills3 and Harvey T -
Molecular Biology of the CellVol. 13, 3775–3786, November 2002 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/22_Kim_SJ_MBC_2002.pdf31 Oct 2002: Molecular Biology of the CellVol. 13, 3775–3786, November 2002. Cotranslational Partitioning of Nascent Prion Proteininto Multiple Populations at the Translocation ChannelSoo Jung Kim and Ramanujan S. Hegde†. Laboratory of Cellular Oncology, -
CELL AND MOLECULAR PHYSIOLOGY Intracellular Ca2+ release via the ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/44_Ong_HL_Pflug_Arch_2007.pdf15 Feb 2007: Measurements weredone after 24 h. [Ca2+]i measurements. Measurements were conducted as described previously[19]. ... 24. Paschen W, Doutheil J, Gissel C, Treiman M (1996) Depletion ofneuronal endoplasmic reticulum calcium stores by thapsigargin:effect on -
doi:10.1016/j.tibs.2006.08.004
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/42_Bernstein_HD_TIBS_2006.pdf17 Aug 2006: Myristoylation ofthe N domain of the signal sequence of the NADH cyto-chrome b5 reductase inhibits its recognition by SRP [24].This competition between SRP binding and myristoylationtargets the nascent polypeptide ... J. Bacteriol. 187,2983–2991. 24 -
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS PSTPIP2 deficiency in mice …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Blood-2012-Chitu-3126-35.pdf12 Oct 2012: Prepublished online asBlood First Edition paper, August 24, 2012; DOI 10.1182/blood-2012-04-425595. ... PSTPIP2expression was reconstituted by MSCV-IRES-GFP retroviral transductionas described.24. Biochemical characterization of PSTPIP2 mutants. -
Cellular/Molecular Endophilin Drives the Fast Mode of Vesicle…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Llobet%20J%20Neurosci2011.pdf23 Sep 2011: Neuron 24:143–154. Rosenmund C, Stevens CF (1997) The rate of aldehyde fixation of the exo-cytotic machinery in cultured hippocampal synapses. ... J Neurosci 24:8641– 8650. Verstreken P, Kjaerulff O, Lloyd TE, Atkinson R, Zhou Y, Meinertzhagen -
Manipulating Ligands Using Coot with a bit of carbohydrates ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/coot-may-2017-ligands-madrid-mcs2017-csic.pdf10 May 2017: C6 - N1 target: 108.00 model_angle: 122.80 sigma: 3.00 angle-devi 14.80 penalty-score: 24.34 angle O2 - C6 - C3 target: 108.00 model_angle: 122.76 ... sigma: 3.00 angle-devi 14.76 penalty-score: 24.19 angle C13 - C15 - C17 target: 120.00 model_angle: -
THE JOURNAL OF BIOLOGICAL CHEMWXXY Vol. 265, No. 34, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/2_Pewitt_EB_JBC_1990b.pdf29 Dec 2004: rg/ ml for 24 h at 37 “C). -
Molecular Biology of the CellVol. 21, 4325– 4337, December ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/67_Emerman_AE_MBC_2010.pdf11 Nov 2011: Transfection was with either Lipofectamine 2000 or Effectene withsimilar results. Cells were assayed between 24 and 48 h after transfection. ... A) SA-PrP and SS-PrP lacking orcontaining the BioTag were transfected intoBirA-expressing N2a cells and -
Dbouk 1..13
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/vadas_science_signaling.pdf5 Dec 2012: D) Bonemarrow–derived macrophages and CellTracker Red–labeled PC-3 tumor cells were coplated in 24-welldishes and overlaid with collagen. ... Cells were incubated for 24 hours in the absence or presence ofp110b-derived peptide or scrambled peptide, -
Morpheus stock solutions poster portrait A2
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/WWWrobots/PDF/PresentationsOther/Morpheus_stock_solutions_poster.pdf1 Jun 2018: 6 34 668.7 28 728.8 24 768.9 19 819.0 16 84. -
JCB: Article The Rockefeller University Press $30.00J. Cell Biol. ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/J%20Cell%20Biol%202010%20Howes.pdf24 Aug 2011: on August 24, 2011. jcb.rupress.orgD. ownloaded from. Published August 16, 2010. ... Error bars show SEM. on August 24, 2011. jcb.rupress.orgD. ownloaded from. -
doi:10.1016/j.cell.2006.10.032
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/43_Kang_SW_Cell_2006.pdf30 Nov 2006: B) Cells stably expressing PrP or Opn-PrP. were treated with 10 mM DTT for 24 hr, re-. ... or Opn-PrP (black bars) after the indicated. treatments for 24 hr (5 mM MG132), 6 hr (10. -
Deubiquitinases Sharpen Substrate Discrimination during Membrane…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/82_Zhang_ZR_Cell_2013.pdf5 Aug 2013: panel) plasmids were cotransfected with a fixed. amount (100 ng) of CD4 and analyzed 24 hr later by. -
SVUS002-16.tex
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/31_Rane_Chapter_2005.pdf21 Sep 2006: 21–24).Thus, PrP can apparently cause disease in two ways. In transmissibleforms of the disease, PrPSc can induce the misfolding of host PrPC intoadditional copies of PrPSc. -
Coot Tools for Cryo-EM Paul EmsleyMRC Laboratory of Molecular ...
https://www2.mrc-lmb.cam.ac.uk/personal/pemsley/coot/files/presentations/coot-cryoEM-2018-Aug-Stockholm.pdf15 Aug 2018: Slide 23. Slide 24. Slide 25. Slide 26. Slide 27. Slide 28. -
Chapter 20 In Vitro Dissection of Protein Translocationinto the ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/62_Sharma_AS_MMB_2010.pdf30 Apr 2010: Chapter 20. In Vitro Dissection of Protein Translocationinto the Mammalian Endoplasmic Reticulum. Ajay Sharma, Malaiyalam Mariappan, Suhila Appathurai,and Ramanujan S. Hegde. Abstract. In eukaryotic cells, roughly one-fourth of all mRNAs code for
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