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Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK
https://www.ch.cam.ac.uk/pfei/alan-fersht2 Jul 2024: We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of ... Cancer is a disease of mutation, and the most commonly mutated -
Gerard Evan | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/evan3 Jul 2024: a downstream conduit for many (perhaps all) oncogenic growth signals, and a second mouse that models pharmacological restoration of the p53 tumour suppressor, which is functionally inactivated in most human cancers. ... Since it is the endogenous -
Extra centrosomes and cancer : New light on a century old problem |…
https://www.gen.cam.ac.uk/news/coelho-extra-centrosomes-and-cancer3 Jul 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development. -
CDD-MRC Conference on “Genes vs Environment in Cancer” | MRC…
https://www.mrc-tox.cam.ac.uk/news/cdd-mrc-conference-genes-vs-environment-cancer3 Jul 2024: During the conference the Prof. Karen Vousden from The Crick Institute, London, was awarded of the CDD Award 2018 for her pioneering studies on the function of the tumour suppressor protein ... p53 in the response to environmental stressors. -
Protein engineering pioneer awarded Royal Society Copley Medal |…
https://www.ch.cam.ac.uk/news/protein-engineering-pioneer-awarded-royal-society-copley-medal2 Jul 2024: His work is now focussed on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53 – the so-called “Guardian of the Genome” – in order to design novel -
Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/
20 May 2024:
Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Search Publications | Publications
https://publications.ch.cam.ac.uk/publications-search?page=8202 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on -
Search Publications | Publications
https://publications.ch.cam.ac.uk/publications-search?page=7852 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on
20 May 2024:
Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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