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11 - 20 of 25 search results for `tumour suppressor p53`

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  2. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

  3. Emeritus - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/
    Thumbnail for Emeritus - MRC Laboratory of Molecular Biology 21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.

  4. https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11070

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/11070
    can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

  5. https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/61
    {"id":61,"date":"2012-06-25T10:03:42","date_gmt":"2012-06-25T10:03:42","guid":{"rendered":"http://www2.mrc-lmb.cam.ac.uk/wordpress/?page_id=61"},"modified":"2024-05-20T14:39:16","modified_gmt":"2024-05-20T13:39:16","slug":"protein-and-nucleic-acid-ch

  6. Researchers "drug the undruggable" - MRC Laboratory of…

    https://www2.mrc-lmb.cam.ac.uk/researchers-drug-undruggable/
    Thumbnail for Researchers "drug the undruggable" - MRC Laboratory of Molecular Biology 20 Oct 2017: can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.
    By: pmabbs, @MRC_LMB

  7. https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3293
    nAlan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.

  8. https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/18741

    https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/18741
    {"id":18741,"date":"2020-08-04T17:10:07","date_gmt":"2020-08-04T16:10:07","guid":{"rendered":"https://www2.mrc-lmb.cam.ac.uk/?p=18741"},"modified":"2020-08-04T17:10:09","modified_gmt":"2020-08-04T16:10:09","slug":"alan-fersht-and-marta-zlatic-win-roy

  9. Reporter 11/7/01: Approved for degrees

    https://www.reporter.admin.cam.ac.uk/reporter/2000-01/weekly/5852/31.html
    29 Nov 2011: T. M. Rippin, TH. Mechanistic studies of the tumour suppressor p53: a basis for rational anti-cancer drug design. ... Stability, folding and evolution of the tumour suppressor protein p16. L.

  10. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... and Colombo, E.(2011) The lymphoma-associated NPM-ALK oncogene elicits a

  11. LMB continues pioneering work started in CPE - MRC Laboratory of…

    https://www2.mrc-lmb.cam.ac.uk/lmb-continues-pioneering-work-started-in-cpe/
    Thumbnail for LMB continues pioneering work started in CPE - MRC Laboratory of Molecular Biology 24 Sep 2010: Alan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.
    By: pmabbs, @MRC_LMB

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