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Alan rejoined the LMB in 2010, where he continued his work on protein folding, misfolding and disease, concentrating on the tumour suppressor p53 until the end of 2017. ... n. Cancer is a disease of mutation, and the most commonly mutated protein by far

can bind to and deactivate an enzyme that controls the stability of the p53 tumour suppressor protein. ... This deactivation allows p53 to be turned on, putting the brakes on cancer growth.

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nAlan will continue to lead his research on the p53 tumour suppressor protein at the LMB with an MRC programme grant for the next five years.

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The p53 tumour suppressor is a transcription factor that regulatesthe progression of the cell through its cycle and cell death(apoptosis) in response to environmental stimuli such as DNAdamage and ... Thus, incontrast to p53, p63 is essential for several

A microRNA componentof the p53 tumour suppressor network. Nature.2007;447(7148):1130-1134. 39. Raver-Shapira N, Marciano E, Meiri E, et al. ... Chang TC, Wentzel EA, Kent OA, et al. Transacti-vation of miR-34a by p53 broadly influences geneexpression and