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21 Sep 2006: The second less obvious,but equally plausible possibility (model B) is that neuronal damage re-sults from a derangement in some aspect of normal PrPC metabolism.In this view such altered ... It was therefore logical and simplerto propose that PrPSc

16 May 2013: poly(A) tail (Figure 2A).Translation of b-VHP-pA produced a heterogeneous set of prod-ucts, some of which contained a tethered tRNA, as evidenced bytheir sensitivity to RNase digestion ... internal polylysine domain (b-VHP-K12) (Figure 2A). As

20 Nov 2010: However, the fusion peptideis clearly more than just a hold on a target membrane,because some amino acid substitutions within the fusionpeptide inhibit fusion without lowering peptide–mem-brane binding. ... 704. membrane stresses, has been confirmed in

31 Oct 2005: Indeed, several abundant membrane components havebeen identified associated with the translocon (some with large cytosolic domains such as p180)84. ... 1) provides several. advantages to the cell, some of which are more obvious than others.

8 Nov 2004: inefficiency in the activity of some signals, we turned our. attention to native PrP. ... some activity. Remarkably, as assessed by either Annexin V. exposure on the extracellular surface (Figure 8A and B) or.

14 Jul 2011: 3b, c). Thus, the Bag6 complex captures substratesconcomitant with or after the release of nascent chains from the ribo-some; these same hydrophobic domains are bound by the SRP as longas ... After ubiquitination,BAG6 might chaperone its

3 Feb 1997: SDS-PAGE was per-formed using 15% gels, and some gels were fluorographed using Enhance(Dupont Co., Willmington, DE). ... some of the ma-terial in complexes A, B, and C constitutes intermediatesin the biogenesis of completed 750-S capsids.

30 Nov 2006: synthesis to degradation) is regulated for at least some. substrates at one time or another. ... observed in some lanes. (B) Analysis of overloaded samples prepared as in (A) reveals increased amounts of BiP in both high-molecular-weight fractions (HMW)

13 May 2013: the spot intensity.In practice, however, there is always some background, so this needs to be taken into account. ... that spots close to each other on the detector (even on different images) have similar profiles has some validity.

24 Aug 2011: We next sought to verify some key targets as novel cargo for the CLIC pathway. ... In some instances, intriguing tubular networks were seen with labeling for anti–CD44-HRP after 40 min of internal-ization (Fig.

Arndt, U.W. (1953) X-ray Scattering by Some Native and Denatured Proteins in the solid state. ... 1954) Some X-ray Scattering Results on Nucleoproteins and their Components Trans Faraday Soc.

9 Nov 2011: Most types of membrane proteins are inserted by a cotranslational pathway, although some use a posttranslational pathway.ER, endoplasmic reticulum. ... c) Three-dimensional structure of bovine rhodopsin showing that TMDs arehighly variable in structure;

30 Jan 2004: S3A). Some of these tubulesemanated from the plasma membrane andwere accessible to the membrane fluorescentdye FM2-10. ... 4), and discovered BARs inmany different contexts. Some BAR proteinshave additional lipid interactions through adjacentpleckstrin

26 Aug 2021: 1E). The mRNAs for de-graded subunits of the proteasome and ribo-some were overrepresented by around 1.5- to2-fold in MCF7 cells, but not other breast can-cer cell ... A. B. 0.8% input 100%33%. PAAF1. PSMC5. 460. 55. 41. 5543.

13 May 2013: the spot intensity.In practice, however, there is always some background, so this needs to be taken into account. ... that spots close to each other on the detector (even on different images) have similar profiles has some validity.

11 Jun 2013: Twins by reAcular merohedry (inc some OD-‐twins), allotwins, disordered structures -‐ Can be readily seen in diffracAon images (with spot predicAons shown). ... Molecular Replacement: –Two structures are globally very similar (e.g. rmsd = 0.5A)

26 Oct 2008: 1. Introduction. The native structure of biological specimens can be investigated with the electron microscope at high resolution if some means is provided for retaining their hydration in the surrounding high ... This stage has features which over- come

28 Nov 2006: TNF-treatment induces a rapid activation of IKK which in turnphosphorylates IB leading to the ubiquitination and protea-some-mediated degradation of IB. ... In the light of our results,we speculate that some of these effects might be due to thetransfer

16 Jul 2008: The very common fold consists of three helices (H1-H3) and a wing with some. ... A is in red, B is in yellow. and C is in blue.

Rev Mol Cell Biol/span span class="pubJournalRef"strong25/strong(3): 168-186/span/li/ulh3 id="pub2023"2023/h3ul class="lmbpubmedpapers"lispan class="pubAuthors"Querido, J.B., et al./span ... a href="http://www.ncbi.nlm.nih.gov/pubmed/19955257"

19 Apr 2006: 2). Occasional mistakes in the primers do occurand in some rare cases strand displacement activity of PfuTurbok has introduced unwantedinsertions (data not shown). ... Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of

31 Aug 2018: 1.2.4.4.The model now looks like it fits the map a great deal better, but there is still some room for improvement so we will carry interactively refine ... In some cases this can be very helpful. 1.2.7.6.His 17 has been built without a side chain, but

17 Mar 2004: The newly recognized BAR(Bin/Amphiphysin/Rvs) domain is present in a numberof proteins — amphiphysins, endophilin, arfaptins,nadrins, beta-centaurins and oligophrenins — some ofwhich are critical for the recycling of synaptic ... Theends and concave

3 Dec 2005: 35. A B. C D. E F. Fig. 7. Some best-fit results of deformable template matching. ... Some figures arerotated for plotting. (A) A fully laid egg in perfect condition.

6 Mar 2001: Some studies have also reported ssion of lipidtubules by dynamin (possibly involving a pinching/constrictionaction)13,16. ... dynamin transfections. This mutant also shows some uptake of transferrin at a perinuclear.

26 Nov 2012: To complete the investigation, some biological specimens are also examined with the phase plate in position, and a comparison is. ... a). (b). 1 1. FIGURE 9. Densitometer traces of some features shown in figures 8(a) and (b) illustrating improvements in

1 Mar 2024: Fig. 3a,b). As SepF depletion progressed, cells became filamentous and, after 6 h, CdpB1’s ring-like structures began to fade whereas CdpB2 maintained some localization at division sites. ... Demographic analysis shows that the highest signal intensity

16 Jun 2006: b a t i o n for 4 - 5 w k at 17C. ... Some lines of the surface lattice and the choice of unit cell used are indicated in B.

27 Nov 2003: Equivalent proteinsare found in most other non-spherical bacteria. Mutantslacking MreB are round instead of rod-shaped; however,some non-spherical bacteria that naturally lack actin-likeproteins control their shape by ... Some of the cytoskeleton

30 Jan 2004: S3A). Some of these tubulesemanated from the plasma membrane andwere accessible to the membrane fluorescentdye FM2-10. ... 4), and discovered BARs inmany different contexts. Some BAR proteinshave additional lipid interactions through adjacentpleckstrin

27 Apr 2016: 2.2.4.4. The model now looks like it fits the map a great deal better, but there is still some room for improvement so we will carry interactively refine ... 3.1.4. Leave fields “Phases”, TLS coefficients” and “Reference model” may be left as

1 Nov 2012: 1 B. The shoulder associated with some of the (1,0) peaks is due to contamination from the meridian. ... may exert constraints on changes, possibly leading to some distortion o f the structure.

10 Sep 1999: In contrast, no nucleotidebinding was found for the N-terminal 342 residues ofMukB (unpublished observations), but some hydrolysisof ATP and GTP has been reported [15]. ... 17. Miroux, B. & Walker, J.E. (1996). Overproduction of proteins inEscherichia

31 Aug 2006: Dab2/Disabled2 (a cargo adaptor for proteins like megalin)binds to both a and b appendages, and it is likely that some ofthe other accessory proteins that bind to both a ... Nevertheless some acces-sory adaptors like b-arrestin (for internalisation of

9 Jan 2003: Some of the key residues in the human epsinR sequence referred to in the paper are numbered. ... 4 B; see Fig. 1 D for con-structs used), to the N3 construct of epsinR, with some fur-ther clathrin binding found in the N2 construct (Fig.

1 Mar 2021: The Coot User Manual

10 Dec 2014: set-variable -Wno-unused-result -O -P conftest.c &5 configure:5925: /usr/bin/nm -B "conftest.o" configure:5928: output 0000000000000000 B some_variable configure:5935: result: BSD nm ... Some functions are actually named | something starting with __ and

7 Dec 2006: held together via hydrophobic interactions betweenleucine residues, some of them participating in a heptarepeat typical of leucine zippers (Figs 1B and 3). ... The sequence of the cytoplasmic tail of MreC isquite variable and is very short in some

11 Jun 2013: Twins by reAcular merohedry (inc some OD-‐twins), allotwins, disordered structures -‐ Can be readily seen in diffracAon images (with spot predicAons shown). ... Molecular Replacement: –Two structures are globally very similar (e.g. rmsd = 0.5A)

13 May 2013: the spot intensity.In practice, however, there is always some background, so this needs to be taken into account. ... that spots close to each other on the detector (even on different images) have similar profiles has some validity.