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26 Oct 2008: 1. Introduction. The native structure of biological specimens can be investigated with the electron microscope at high resolution if some means is provided for retaining their hydration in the surrounding high ... This stage has features which over- come

31 Aug 2018: 1.2.4.4.The model now looks like it fits the map a great deal better, but there is still some room for improvement so we will carry interactively refine ... In some cases this can be very helpful. 1.2.7.6.His 17 has been built without a side chain, but

16 Jul 2008: The very common fold consists of three helices (H1-H3) and a wing with some. ... A is in red, B is in yellow. and C is in blue.

17 Mar 2004: The newly recognized BAR(Bin/Amphiphysin/Rvs) domain is present in a numberof proteins — amphiphysins, endophilin, arfaptins,nadrins, beta-centaurins and oligophrenins — some ofwhich are critical for the recycling of synaptic ... Theends and concave

19 Apr 2006: 2). Occasional mistakes in the primers do occurand in some rare cases strand displacement activity of PfuTurbok has introduced unwantedinsertions (data not shown). ... Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of

31 Aug 2018: 1.2.4.4.The model now looks like it fits the map a great deal better, but there is still some room for improvement so we will carry interactively refine ... In some cases this can be very helpful. 1.2.7.6.His 17 has been built without a side chain, but

28 Nov 2006: TNF-treatment induces a rapid activation of IKK which in turnphosphorylates IB leading to the ubiquitination and protea-some-mediated degradation of IB. ... In the light of our results,we speculate that some of these effects might be due to thetransfer

6 Mar 2001: Some studies have also reported ssion of lipidtubules by dynamin (possibly involving a pinching/constrictionaction)13,16. ... dynamin transfections. This mutant also shows some uptake of transferrin at a perinuclear.

30 Jan 2004: S3A). Some of these tubulesemanated from the plasma membrane andwere accessible to the membrane fluorescentdye FM2-10. ... 4), and discovered BARs inmany different contexts. Some BAR proteinshave additional lipid interactions through adjacentpleckstrin

26 Nov 2012: To complete the investigation, some biological specimens are also examined with the phase plate in position, and a comparison is. ... a). (b). 1 1. FIGURE 9. Densitometer traces of some features shown in figures 8(a) and (b) illustrating improvements in

10 Sep 1999: In contrast, no nucleotidebinding was found for the N-terminal 342 residues ofMukB (unpublished observations), but some hydrolysisof ATP and GTP has been reported [15]. ... 17. Miroux, B. & Walker, J.E. (1996). Overproduction of proteins inEscherichia

16 Jun 2006: b a t i o n for 4 - 5 w k at 17C. ... Some lines of the surface lattice and the choice of unit cell used are indicated in B.

27 Nov 2003: Equivalent proteinsare found in most other non-spherical bacteria. Mutantslacking MreB are round instead of rod-shaped; however,some non-spherical bacteria that naturally lack actin-likeproteins control their shape by ... Some of the cytoskeleton

1 Nov 2012: 1 B. The shoulder associated with some of the (1,0) peaks is due to contamination from the meridian. ... may exert constraints on changes, possibly leading to some distortion o f the structure.

20 Feb 2001: 1998). Chromo-some dynamics: the SMC protein family. Curr.Opin. Genet. Dev. 8, 254-259. ... Mol.Microbiol. 17, 1215-1217. Strunnikov, A. V. (1998). SMC proteins and chromo-some structure.

11 Mar 1999: In the case of some TM domains, the core translo-con might suffice2,25. ... Thus, thecurrently mysterious normal function of PrP, as wellas development of some of its associated diseases35,might be regulated at the level of protein biogenesisand topology.

9 Jan 2003: Some of the key residues in the human epsinR sequence referred to in the paper are numbered. ... 4 B; see Fig. 1 D for con-structs used), to the N3 construct of epsinR, with some fur-ther clathrin binding found in the N2 construct (Fig.

3 Dec 2005: 35. A B. C D. E F. Fig. 7. Some best-fit results of deformable template matching. ... Some figures arerotated for plotting. (A) A fully laid egg in perfect condition.

16 Jul 1998: However, secPrP and NtmPrPwere made efficiently in only some of the membranepreparations, showing optimal translocation at 0.5%and 0.45%, respectively. ... minimal machinery necessary for translocation (SRP re-ceptor, Sec61 complex, and in some cases TRAM

7 Dec 2006: held together via hydrophobic interactions betweenleucine residues, some of them participating in a heptarepeat typical of leucine zippers (Figs 1B and 3). ... The sequence of the cytoplasmic tail of MreC isquite variable and is very short in some

16 Aug 2004: ZapA is pre-dominantly dimeric (MW 23,612 Da) although some tetramer (MW 52,619 Da) exists at this concentration.D, Increasing ZapA concentration (2.5 mg/ml (A280 0.75)) ... B, Confirmation of stoichiometric relationshipobserved in A: titration of ZapA

17 Sep 2008: Almost certainly, cells were able to divide, by some unknown. eans, before this protein fold was perfected. ... BtubAB was found in some deep-branching VerrucomicrobiaJenkins et al., 2002) and forms longitudinal protofilaments withlternating A and B

20 Apr 2002: In addi-tion to calcium, the activation of cPLA2 by some agonists re-quires phosphorylation of the enzyme (7, 8). ... The model showed that the molecular replacement solution hadcorrectly placed the b-sheets, but some loop conformations,

1 Mar 2024: Fig. 3a,b). As SepF depletion progressed, cells became filamentous and, after 6 h, CdpB1’s ring-like structures began to fade whereas CdpB2 maintained some localization at division sites. ... Demographic analysis shows that the highest signal intensity

3 Nov 2001: Consequently residues 35-60 are not included in the model of the a-tubulin.Some improvement was, however, visible for the. ... Generally residues involved directly in nucleo-tide binding and hydrolysis are highly conservedbetween a and b-subunits, with

30 Jun 2004: et al. , 2002).Identification and characterization of a bacterial chromo-some partitioning site revealed 10 pseudopalindromic16 bp sequences found in the origin-proximal 20% of the. ... Res. idua. l (D. 23. 0). SpoOJ C-terminus (Spo0J223-269). A B.

21 Feb 2011: However, the fusion peptideis clearly more than just a hold on a target membrane,because some amino acid substitutions within the fusionpeptide inhibit fusion without lowering peptide–mem-brane binding. ... membrane stresses, has been confirmed in some

4 Mar 2008: Despite the sequential dependency in which the celldivision proteins seem to localize, some of the compo-nents of the divisome can form a complex before theyreach the septum independent of their ... It has been proposed that some of theexposed edges of

17 Aug 2006: 39]. As a result, a fraction of some proteins (e.g. hepatitis B virus precore and. ... b,c) The cleaved signal peptides of some viral. glycoproteins mediate functions that are essential for the viral life cycle.

4 Aug 2008: outer doublet microtubules (Figure 3a-f), some questions. remain about their exact locations and functions. ... Genome BBiioollooggyy 2008, 99::229. It would also be interesting to know what makes some.

31 Aug 2006: Dab2/Disabled2 (a cargo adaptor for proteins like megalin)binds to both a and b appendages, and it is likely that some ofthe other accessory proteins that bind to both a ... Nevertheless some acces-sory adaptors like b-arrestin (for internalisation of

20 May 2010: Full-length protein is a tetramer, although some non-reversible aggregation also occurred. ... Full assignment is shown. (B) Summary of NMR backbone dynamics showing secondary structure elements and alsothat some residues at the C-terminal end are not

28 Feb 1998: cross-linker.served some role in maintaining ribosome binding, then(B) Nascent chain translocation intermediates of pPL-86-mer, pPL-. ... While this still may be the supported by the observation that metabolic conditionsunder which apo B is being

28 Nov 2008: Although GRAF1 can be found primar-ily on long tubules in some cells, other cells within the samepopulation exhibit a predominantly punctate GRAF1 localiza-tion. ... The depicted images are used to show some of the different morphologies of

7 Jun 2010: B) Lumenal substrates and some membrane proteinsaccess the catalytic site by a translocation-dependent mechanism. ... Indeed, some systems may recruitmachinery that is normally not even used for misfoldedproteins (such as bTrCP).

19 Mar 2013: Control samples weretransfected in the same way as the RNAi samples but a scrambledcontrol siRNA oligo (Invitrogen) was used instead.In some experiments, cells were transfected using. ... The addition of GTP to membrane-bound dynaminresulted in some

15 Jul 2005: 3a, b, and data not shown).Immunoprecipitation studies identified the primary differences(Fig. ... Some of the major depleted proteins are indicated (open arrows). b, As in a, except that samples were analyzed by immunoblotting with PDI , Sec61α , TRAM ,

15 Sep 2003: A general property of tubular crystals is thatthere is some variation in the helical pitch (ororientation of the surface lattice), even within agiven helical family. ... There are crescents of about seven suchpeaks and some additional tunnel-lining

20 Apr 2002: Some of the additional sites couldbe within the 2SA protein (containing 24 tyrosine residues), assuggested in Fig. ... These (Tyr771,Tyr783, and Tyr1254) and some additional sites have been iden-tified after in vitro phosphorylation of purified PLC1 by

18 Oct 2008: PICK1 was distributed equally between the two fractions,. suggesting some constitutive membrane association of. ... some intracellular, vesicular accumulation (Figure 5A). However, upon cotransfection with PICK1, we observed.

12 Oct 2012: BmTubR (UniProt Q848W2_BACMQ) lies within an operon con-taining a TubZ homolog in B. ... Proposed ModelBm TubR-DNA. Crystal StructureBt TubR-tubC. Proposedtopological. rearrangement. A B. C D.

20 Jul 2010: dependent protease FtsH, and thus, Lonproteases of the Lon B type fulfil their roles in theseorganisms.22 Some bacteria, such as Thermotogamaritima, Pseudomonas aeruginosa, and Bacillus sub-tilis, express both Lon ... Some of theseinteractions are of a

20 Nov 2010: However, the fusion peptideis clearly more than just a hold on a target membrane,because some amino acid substitutions within the fusionpeptide inhibit fusion without lowering peptide–mem-brane binding. ... 704. membrane stresses, has been confirmed in

4 Apr 2003: Membrane proteins and also some soluble proteins form these crystals through protein-protein interactions or through. ... parameters. Clearly there may be some advantage in repeating the overall procedure using the distortion-corrected structure as a new

6 Apr 2005: Separate resolution curves for the ribo-some and the channel were then calculated from theappropriate volumes. ... The resolution of this map is w14.7 Å(FSC0.5, Figure 1(b)) and some surface-exposedrRNA features are lost due to interactions

27 Jan 2018: In some experiments, nucleased RRL was used. Here, CaCl2 is added to 1 mM and the Ca2+-activated nuclease from S. ... In some reactions, a tripeptide competitive inhibitor of glycosylation (Asn-Tyr-Thr) was added at 50 µM to verify identity of the

14 Jun 2006: B) Distribution of IC50 values for selected inhibitors against PI3-K family members. ... Some IC50 values for AMA-37 and TGX-115 have been reported. previously (Knight et al., 2004).

18 Jan 2018: Division in some cases, others unknown. 14,142,143. CrvA Bacteria Vibrio spp. ... 105,152. PopZ Bacteria Some Gram-negative bacteria. Cell pole marker, signalling hub.

19 Apr 2006: FtsZ isalso present in some chloroplasts and mito-chondria (17, 18). FtsZ in vivo. ... Some bacteria contain several re-lated MreB-like genes. For example B. sub-tilis encodes MreB, Mbl, and MreBH, witheach one showing a similar degree of

30 Jan 2004: S3A). Some of these tubulesemanated from the plasma membrane andwere accessible to the membrane fluorescentdye FM2-10. ... 4), and discovered BARs inmany different contexts. Some BAR proteinshave additional lipid interactions through adjacentpleckstrin