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23 Jul 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ... Eur J Med Chem. (2018). 152,. 101. (doi:The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to

23 Jul 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... It is a major hub protein and interacts with a host of other proteins involved in the cell cycle.

24 Jul 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development.

24 Jul 2024: During the conference the Prof. Karen Vousden from The Crick Institute, London, was awarded of the CDD Award 2018 for her pioneering studies on the function of the tumour suppressor protein ... p53 in the response to environmental stressors.

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... models harboring distinct p53 deficiencies, namely complete loss of p53 (Null); mutations that cause loss of p53 contact with

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge.

23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

23 Jul 2024: J Blumberger – Phys Chem Chem Phys (2008) 10, 5651. (DOI:MR Fernandez-Fernandez, TJ Rutherford, AR Fersht – Protein science : a publication of the Protein Society (2008) 17, 1663.

23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

23 Jul 2024: DOI:MM García-Alai, H Tidow, E Natan, FM Townsley, DB Veprintsev, AR Fersht – Protein Science (2008) 17, 1671.

23 Jul 2024: An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.. ... D Bromley, MR Bauer, AR Fersht, V Daggett – Protein Engineering Design and Selection (2016) 29, 377.

23 Feb 2024: P, Aden K.u00a0/spanEpithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.u00a0span class="docsum-journal-citation ... The unfolded protein response in immunity and

23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

9 Jul 2024: The best students got this correct. Many students also thought the protein, p53 had disulphide bridges. ... p53 was covered in the lectures as a nuclear protein that bound DNA so they should have been aware it is in a reducing environment.