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1 - 4 of 4 search results for `p53 Activity`

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  2. Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen
    23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

  3. Alan Fersht - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/alan-fersht/
    Thumbnail for Alan Fersht - MRC Laboratory of Molecular Biology 21 Jul 2023: We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of ... Exploiting Transient Protein States for the Design of

  4. Dr Ingo Ringshausen - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/
    23 Feb 2024: Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia. ... Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

  5. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E and Turner S.D.(2011) Aberrant Anaplastic Lymphoma Kinase Activity Induces a p53 and Rb-Dependent Senescence-Like Arrest ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017)

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