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1 - 10 of 10 search results for `p53 Activity`

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  2. Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry

    https://www.ch.cam.ac.uk/person/arf25
    23 Jul 2024: doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. ... Cancers (Basel). (2019). 11,. 1151. (doi:Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C

  3. Graduate Poster Display | Pembroke

    https://www.pem.cam.ac.uk/college/news/graduate-poster-display
    19 Jul 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation.

  4. Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK

    https://www.ch.cam.ac.uk/pfei/alan-fersht
    23 Jul 2024: We focus on how mutation affects proteins in the cell cycle, particularly the tumour suppressor p53, in order to design novel anti-cancer drugs that function by restoring the activity of ... Cancer is a disease of mutation, and the most commonly mutated

  5. Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen
    23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

  6. Dr Ingo Ringshausen - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/
    23 Feb 2024: Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia. ... Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

  7. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: Lab Investigation doi: 10.1038/labinvest.2011.96 . McDuff F.K.E and Turner S.D.(2011) Aberrant Anaplastic Lymphoma Kinase Activity Induces a p53 and Rb-Dependent Senescence-Like Arrest ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017)

  8. Search Publications | Publications

    https://publications.ch.cam.ac.uk/publications-search?page=222
    23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

  9. Search Publications | Publications

    https://publications.ch.cam.ac.uk/publications-search?page=300
    23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

  10. Search Publications | Publications

    https://publications.ch.cam.ac.uk/publications-search?page=231
    23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

  11. Search Publications | Publications

    https://publications.ch.cam.ac.uk/publications-search?page=390
    23 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. Please note: all images attached to a publication will be visible on

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