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1 - 6 of 6 search results for `Mutant p53`

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  2. Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry

    https://www.ch.cam.ac.uk/person/arf25
    26 Jul 2024: Future Med Chem. (2019). 11,. 2491. (doi: 10.4155/fmc-2019-0181). SLMP53-2 restoreswild-type-like function to mutant p53 through hsp70: Promising activity in hepatocellular carcinoma. ... European journal of medicinal chemistry. (2018). 152,. 101.

  3. Lucia Pinon P Giraldez | MRC Toxicology Unit

    https://www.mrc-tox.cam.ac.uk/staff/lucia-pinon-p-giraldez
    26 Jul 2024: Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane. ... Genomic instability in mutant p53 cancer cells upon entotic engulfment.

  4. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: However, as mutant p53 proteins cannot currently be targeted in the clinic, alternative targeting strategies aimed at these tumours are required. ... To identify mutant p53-dependent therapeutic vulnerabilities in lung tumours, Dr Carla Martins and her

  5. Dr Ben Hall | Department of Genetics

    https://www.gen.cam.ac.uk/staff/dr-ben-hall
    26 Jul 2024: Research Group Links. Key publications:. Michael Hall, Philip H Jones, Benjamin A Hall: Relating evolutionary selection and mutant clonal dynamics in normal epithelia Journal of the Royal Society: Interface, 16(156) ... p53 mutant progenitors colonize

  6. Computational modelling of cancer and aging | Department of Genetics

    https://www.gen.cam.ac.uk/research/research-groups/computational-modelling-cancer-and-aging
    26 Jul 2024: Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia. ... Jones Mutant clones in normal epithelium outcompete and eliminate emerging tumours.

  7. Publications: Biology

    www.tcm.phy.cam.ac.uk/~bds10/dir/publications_bio.html
    15 Jun 2024: Simons. doi:10.1016/j.stem.2010.05.017. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

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