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10 Jul 2024: These results suggest that CRISPR/Cas9 selects against cells with a functional p53 pathway, which can explain the higher efficiency of CRISPR/Cas9 in tumour cell lines where the p53 DNA ... A delicate balance is required, however, as p53 inhibition can

10 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

10 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

9 Jul 2024: Search site. Publications. Uploading Images. Members of the Department can attach an image to a publication by clicking on the title of the publication in the listing below. ... Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed

9 Jul 2024: This stress in turn activates a catabolic process, known as autophagy that leads to the death of the abnormal cells in a p53-dependent process. ... Future studies in higher mammalian species are however required to reveal if p53-dependent autophagy and

10 Jul 2024: S., Gilbert-Jaramillo, J., Afzal, M., Napier, A., James, WS., Bjorkman, PJ., Townsend, AR. ... H-J., Andersson, A-MC., Barrett, JR., Bowden, TA., Draper, SJ., Townsend, AR.

23 Feb 2024: Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner” Mol Cell. ... Watson JK, Rulands S, Wilkinson AC, Wuidart A, Ousset M, Van Keymeulen A, Göttgens B, Blanpain C, Simons BD, Rawlins EL, “Clonal Dynamics