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    https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cohesin%20folding%202021%20elife-67268-v1.pdf
    14 Jul 2021: Smc1/Smc3 hinge interface are also capable of bypassing the need for Scc4. ... arms merely because defective loading at CENs increases the amount of cohesin available to load.

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