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p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry
https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells20 May 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations. -
Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors. -
Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf2520 May 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. -
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/posts/3320 -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-42You are in:Title: West side of Sermilik Fjord. Reference: P53/43/42. Reference: P53/43/42. -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-135You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/135. Reference: P53/43/135. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-231Reference: P53/43/231. Reference: P53/43/231. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-262Reference: P53/43/262. Reference: P53/43/262. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-388Reference: P53/43/388. Reference: P53/43/388. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-497Reference: P53/43/497. Reference: P53/43/497. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931).
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