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p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry
https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells21 May 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations. -
Gerard Evan | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/evan21 May 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors. -
Professor David Keays | Department of Physiology, Development and…
https://www.pdn.cam.ac.uk/staff/keays21 May 2024: Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. -
Publications | Cambridge Infinitus Research Centre
https://circe.ceb.cam.ac.uk/publications21 May 2024: Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric interference in mytosis, J. -
Dr Emma L Rawlins | Department of Physiology, Development and…
https://www.pdn.cam.ac.uk/directory/emma-rawlins21 May 2024: 2016) Mechanical cell competition kills cells via induction of lethal p53 levels. -
Extra centrosomes and cancer : New light on a century old problem |…
https://www.gen.cam.ac.uk/news/coelho-extra-centrosomes-and-cancer21 May 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development. -
Publications | Department of Pharmacology
https://www.phar.cam.ac.uk/research/Itzhaki/pub21 May 2024: S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ... S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2. -
Jussi Taipale | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/taipale21 May 2024: CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat. Med., 24(7):927-930. -
Svetlana Khoronenkova | Department of Biochemistry
https://www.bioc.cam.ac.uk/research/khoronenkova21 May 2024: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. -
Dr Ben Hall | Department of Genetics
https://www.gen.cam.ac.uk/staff/dr-ben-hall21 May 2024: p53 mutant progenitors colonize normal epidermis Cell Stem Cell 23(5)/2018 DOI: 10.1016/j.stem.2018.08.017.
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