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https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117
https://www2.mrc-lmb.cam.ac.uk/wp-json/wp/v2/pages/117 -
p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry
https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells21 May 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations. -
Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry
https://www.ch.cam.ac.uk/person/arf2520 May 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. -
Therapeutic vulnerabilities in lung tumours with distinct p53…
https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors. -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-42You are in:Title: West side of Sermilik Fjord. Reference: P53/43/42. Reference: P53/43/42. -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-135You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/135. Reference: P53/43/135. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-231Reference: P53/43/231. Reference: P53/43/231. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-262Reference: P53/43/262. Reference: P53/43/262. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-388Reference: P53/43/388. Reference: P53/43/388. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-497Reference: P53/43/497. Reference: P53/43/497. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-540Reference: P53/43/540. Reference: P53/43/540. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931). -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-34You are in:Title: West side of Sermilik Fjord. Reference: P53/43/34. Reference: P53/43/34. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-85You are in:Title: Sermilik (?). Reference: P53/43/85. Reference: P53/43/85. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » Watkins Mountains
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-543You are in:Title: Watkins Mountains. Reference: P53/43/543. Reference: P53/43/543. Title: Watkins Mountains. -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-137You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/137. Reference: P53/43/137. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-278Reference: P53/43/278. Reference: P53/43/278. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-424Reference: P53/43/424. Reference: P53/43/424. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-468Reference: P53/43/468. Reference: P53/43/468. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-535Reference: P53/43/535. Reference: P53/43/535. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931). -
Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK
https://www.ch.cam.ac.uk/pfei/alan-fersht20 May 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules. -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-40You are in:Title: West side of Sermilik Fjord. Reference: P53/43/40. Reference: P53/43/40. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-90You are in:Title: Sermilik (?). Reference: P53/43/90. Reference: P53/43/90. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-91You are in:Title: Sermilik (?). Reference: P53/43/91. Reference: P53/43/91. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-134You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/134. Reference: P53/43/134. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-253Reference: P53/43/253. Reference: P53/43/253. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-441Reference: P53/43/441. Reference: P53/43/441. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-493Reference: P53/43/493. Reference: P53/43/493. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-533Reference: P53/43/533. Reference: P53/43/533. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931). -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-48You are in:Title: West side of Sermilik Fjord. Reference: P53/43/48. Reference: P53/43/48. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-88You are in:Title: Sermilik (?). Reference: P53/43/88. Reference: P53/43/88. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-142You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/142. Reference: P53/43/142. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-240Reference: P53/43/240. Reference: P53/43/240. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-409Reference: P53/43/409. Reference: P53/43/409. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-419Reference: P53/43/419. Reference: P53/43/419. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-35You are in:Title: West side of Sermilik Fjord. Reference: P53/43/35. Reference: P53/43/35. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-93You are in:Title: Sermilik (?). Reference: P53/43/93. Reference: P53/43/93. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-487Reference: P53/43/487. Reference: P53/43/487. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-136You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/136. Reference: P53/43/136. -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-425Reference: P53/43/425. Reference: P53/43/425. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-506Reference: P53/43/506. Reference: P53/43/506. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-47You are in:Title: West side of Sermilik Fjord. Reference: P53/43/47. Reference: P53/43/47. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-94You are in:Title: Sermilik (?). Reference: P53/43/94. Reference: P53/43/94. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-243Reference: P53/43/243. Reference: P53/43/243. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-478Reference: P53/43/478. Reference: P53/43/478. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). -
Freeze Frame » South coast of Angmagssalik Island
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-139You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/139. Reference: P53/43/139. -
Freeze Frame » West side of Sermilik Fjord
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-36You are in:Title: West side of Sermilik Fjord. Reference: P53/43/36. Reference: P53/43/36. -
Freeze Frame » Sermilik (?)
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-89You are in:Title: Sermilik (?). Reference: P53/43/89. Reference: P53/43/89. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31. -
Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-270Reference: P53/43/270. Reference: P53/43/270. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-438Reference: P53/43/438. Reference: P53/43/438. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Coast from Umivik to the south-west corner of…
https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-483Reference: P53/43/483. Reference: P53/43/483. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931).
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