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21 May 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

20 May 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

You are in:Title: West side of Sermilik Fjord. Reference: P53/43/42. Reference: P53/43/42.

You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/135. Reference: P53/43/135.

Reference: P53/43/231. Reference: P53/43/231. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

Reference: P53/43/262. Reference: P53/43/262. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

Reference: P53/43/388. Reference: P53/43/388. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930).

Reference: P53/43/497. Reference: P53/43/497. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931).

Reference: P53/43/540. Reference: P53/43/540. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931).

You are in:Title: West side of Sermilik Fjord. Reference: P53/43/34. Reference: P53/43/34.

You are in:Title: Sermilik (?). Reference: P53/43/85. Reference: P53/43/85. Title: Sermilik (?). Description: glass plate negative. Collection: British Arctic Air Route Expedition 1930-31.

You are in:Title: Watkins Mountains. Reference: P53/43/543. Reference: P53/43/543. Title: Watkins Mountains.

You are in:Title: South coast of Angmagssalik Island. Reference: P53/43/137. Reference: P53/43/137.

Reference: P53/43/278. Reference: P53/43/278. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

Reference: P53/43/424. Reference: P53/43/424. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930).

Reference: P53/43/468. Reference: P53/43/468. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931).

Reference: P53/43/535. Reference: P53/43/535. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931).

20 May 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.