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28 Feb 2023: We then test further these small molecules in human cerebrospinal fluid and in a Caenorhabditis elegans model of AD.

18 Mar 2023: To test for the specificity of compound C for α-synucleinfibrils, we measured the change in polarization uponincubation of compound C with Aβ42 fibrils, which areassociated with Alzheimer’s disease (Figure

28 Feb 2023: Specifically, we test our methodon proteins that were either commercially available or alreadyproduced in our laboratory.

28 Feb 2023: As phase separation has been reported to depend on low-affinity electrostatic and hydrophobic interactions (43, 44), we used this feature to test the sensitivity of the aggregation assay described above

2 Mar 2023: Error bars indicate the standarderror of the mean (SEM). Statistics were performed using ordinaryone-way ANOVA Dunnett’s multiple-comparison test (p-value<0.0001; p-value = 0.0005; p-value = ... Statistical comparisons areshown using an unpaired t-test,

28 Feb 2023: Experimental analysis of aggregation-prone SARS-CoVand SARS-CoV-2 proteinsTo experimentally test the computational predictions of APRs in theSARS-CoV and SARS-CoV-2 proteomes, we investigated the in vitroaggregation ... We performed an MTT assay, a

28 Feb 2023: All samples were prepared in low-binding test tubes. Figure 5. Aβ42 does not change its secondary structure in the presence of varying concentrations of LUVs.