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23 Feb 2024: Stephen Loughran, postdoc, Green lab. "JAK2 phosphorylates the RNA binding protein HNRNPA1 to repress endogenous retrovirus expression and protect haematopoiesis".

23 Feb 2024: 2020) Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. ... 2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

26 Mar 2024: I was wondering how to examine this and noticed something odd: several hundred copies of a fairly new (to our genome) endogenous retrovirus (ERV) were all active in early human embryos

23 Feb 2024: Search site. Ron Lab. vsvg_pseudtyped_retrovirus_101209_0clip_image002.png. 2024 University of Cambridge.

23 Feb 2024: Key Research Questions. How do cells distinguish pathogenic viral nucleic acids from non-pathogenic endogenous nucleic acids? ... Pathogenic viral and non-pathogenic endogenous nucleic acids are often difficult to distinguish.

23 Feb 2024: Elabela/Toddler is an Endogenous Agonist of the Apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary

23 Feb 2024: We also show that loss of endogenous BMP9 leads to lung vascular leak in vivo, and have developed BMP9 variants that maintain endothelial protective function but lack the bone-forming activity.

23 Feb 2024: In first in human, proof of principle studies, MM07 was a more efficacious dilator in human forearm and hand vein via the G-protein mediated pathway than the endogenous peptides. ... and Maguire, J,J. (2017) [Pyr. 1. ]Apelin-13. (1-12). is a biologically

23 Feb 2024: To harness the capacity of endogenous stem cell and progenitor cells for repair and regeneration.

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Site Search. Site Search. John Sinclair. Cambridge Institute of Therapeutic Immunology & Infectious

22 Feb 2024: However, GPR35’s endogenous, relevant ligands and the receptor’s function remain enigmatic. We recently discovered that GPR35 regulates the cell’s ion homeostasis, its metabolic and proliferative activity by interacting

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge.

23 Feb 2024: Activation of the Hypothalamic-Pituitary-Adrenal axis by exogenous and endogenous GDF15. PNAS July 6, 2021, 118 (27) e2106868118;.

23 Feb 2024: endogenous regeneration as a therapeutic strategy to repair duct damage. ... We are trying to understand why this mechanism fails in disease and identify therapeutics modifying the cells’ microenvironment to promote endogenous regeneration.

23 Feb 2024: 2021) Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.

23 Feb 2024: Dr Elizabeth M Rosethorne, Snr Research Fellow, University of Nottingham. Identification of Endogenous and Surrogate Ligands for Orphan GPCRs – Through Computational Drug Design Methods.

23 Feb 2024: Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15. Proc Natl Acad Sci U S A.

23 Feb 2024: Background: The apelin receptor, a class A GPCR, binds two endogenous peptide ligands, apelin and ELA, to induce potent vasodilatation and increase cardiac output. ... Considering these limitations, we are developing a novel method for stimulating

23 Feb 2024: dosing schedules, we have been able to closely replicate the changes in endogenous cortisol levels observed in traders during periods of increased market volatility,” says Dr Mark Gurnell from the Institute

23 Apr 2024: His application of forward-genetic screens discovered the Human Silencing Hub ‘HUSH’, the critical transcriptional epigenetic repressor complex for silencing both newly integrated retroviruses and mobile endogenous retrotransposons.