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PhD & postdoc Seminars | Wellcome-MRC Cambridge Stem Cell…
https://www.stemcells.cam.ac.uk/events/phd-postdoc-seminars23 Feb 2024: Stephen Loughran, postdoc, Green lab. "JAK2 phosphorylates the RNA binding protein HNRNPA1 to repress endogenous retrovirus expression and protect haematopoiesis". -
Churchill College Alumnus awarded Humboldt Prize for World-leading…
https://www.chu.cam.ac.uk/news/news-and-events/churchill-college-alumnus-awarded-humboldt-prize-for-world-leading-evolutionary-genetics-research/26 Mar 2024: I was wondering how to examine this and noticed something odd: several hundred copies of a fairly new (to our genome) endogenous retrovirus (ERV) were all active in early human embryos -
Publications | Coleman Laboratory
https://colemanlab.brc.cam.ac.uk/publications23 Feb 2024: 2020) Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. ... 2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. Results that match 1 of 2 words
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SISCER Module 12 Lecture 5: Instrumental variables
www.statslab.cam.ac.uk/~qz280/teaching/siscer-2023/L5.pdf5 Apr 2024: I The exposure variable Xi is called confounded or endogenous if it is correlatedwith Ui (or equivalently, if Vi is correlated with Ui ). 9 / 15. Why IV and basics Examples of -
Mendelian randomization
www.statslab.cam.ac.uk/~qz280/talk/mr-tutorial/slides.pdf5 Apr 2024: Exogeneity: Zi (Ui, Vi );3. Exclusion restriction: α = 0. I The exposure variable Xi is called confounded or endogenous if it iscorrelated with Ui (or equivalently, if Vi is correlated with -
Two-Sample Instrumental Variable Analysis: Challenges and Some…
www.statslab.cam.ac.uk/~qz280/publication/two-sample-iv/slides.pdf5 Apr 2024: The two-sample instrumental variable problem. Suppose only Za, xa, Zb, and yb are observed (in other wordsya and xb are not observed).If x is endogenous, what can we learn -
Curriculum Vitae
www.statslab.cam.ac.uk/~qz280/files/cv.pdf20 Mar 2024: S. Small, “ivmodel: An R package for inference andsensitivity analysis of instrumental variables models with one endogenous variable,” Ob-servational Studies, vol. -
LMB Fellows - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/lmb-fellows/23 Apr 2024: His application of forward-genetic screens discovered the Human Silencing Hub ‘HUSH’, the critical transcriptional epigenetic repressor complex for silencing both newly integrated retroviruses and mobile endogenous retrotransposons. -
Dr Fotios Sampaziotis | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/pi/sampaziotis23 Feb 2024: endogenous regeneration as a therapeutic strategy to repair duct damage. ... We are trying to understand why this mechanism fails in disease and identify therapeutics modifying the cells’ microenvironment to promote endogenous regeneration. -
Professor Paul Lehner | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/lehner23 Feb 2024: Remarkably HUSH also silences endogenous mobile retrotransposons like LINE-1 elements, which make up 17% of our genome.
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