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1 - 10 of 188 search results for p53

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  2. p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry

    https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells
    20 May 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

  3. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

  4. Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry

    https://www.ch.cam.ac.uk/person/arf25
    20 May 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

  5. Alan Fersht | 03 - 05 Sept 2017 Cambridge, UK

    https://www.ch.cam.ac.uk/pfei/alan-fersht
    20 May 2024: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... We discovered that about 30% of oncogenic mutants of p53 are just temperatures sensitive and can, in theory, be rescued by small molecules.

  6. Gerard Evan | Department of Biochemistry

    https://www.bioc.cam.ac.uk/research/evan
    20 May 2024: I. (2013). Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. ... 2011). Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

  7. Publications | Cambridge Infinitus Research Centre

    https://circe.ceb.cam.ac.uk/publications
    21 May 2024: Long term aggresome accumulation leads to DNA damage, p53-dependent cell cycle arrest, and steric interference in mytosis, J.

  8. Professor David Keays | Department of Physiology, Development and…

    https://www.pdn.cam.ac.uk/staff/keays
    20 May 2024: Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.

  9. Extra centrosomes and cancer : New light on a century old problem |…

    https://www.gen.cam.ac.uk/news/coelho-extra-centrosomes-and-cancer
    20 May 2024: The net result is hyperplasia in several tissues, which is exacerbated by the additional loss of the tumour suppressor protein p53. ... p53 is non-functional in the majority of human tumours and mice lacking p53 are prone to tumour development.

  10. Dr Emma L Rawlins | Department of Physiology, Development and…

    https://www.pdn.cam.ac.uk/directory/emma-rawlins
    20 May 2024: 2016) Mechanical cell competition kills cells via induction of lethal p53 levels.

  11. Publications | Department of Pharmacology

    https://www.phar.cam.ac.uk/research/Itzhaki/pub
    20 May 2024: S. Itzhaki, and D. R. Spring. Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction. ... S. Verma, and L. S. Itzhaki. Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2.

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