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26 Jan 2021: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Tumour Suppressor p53. Structural Biology and Drug Discovery. Alan Fersht. MRC Laboratory of Molecular Biology.

2 Jul 2021: hotspots within p53 inactivating the tumour suppressor and allowing cancer (lung cancer) to. ... targeting RAS and p53- the most well known proto-oncogene and tumour suppressor-.

7 Sep 2021: L., Stott, K., Watson, M. & Thomas, J. O. HMGB1-facilitated p53 DNA binding occurs via HMG–Box/p53 transactivation domain interaction, regulated by the acidic tail. ... p53 amyloid formation leading to its loss of function: implications in cancer

24 Nov 2021: Inset, model of the molecular mechanism by which ADH5 and CSB cooperate to protect cells from damage, which is sensed by the stalled transcription machinery and can trigger p53 dependent activation

28 May 2021: Motifs with in Gtl2 lncRNA have been shown to be key to the stimulation of the p53 pathway (Uroda et al, 2019, Mol.

4 Oct 2021: Legend. Buddy dataset of mitochondrial disease and dysfunction (20211001). Columns:. Ensembl ID: Ensembl gene identifier. Symbol: Gene symbol. Name: Gene name. IMPI-2021Q4pre: Classification of mitochondrial proteome from IMPI (http://www.mrc-mbu.cam

1 Oct 2021: Table Legend. Supplementary Data: IMPI. Data sets for protein-encoding human genes in Ensembl. Annotation includes: Evidence of subcellular localisation; Manual curation of literature; IMPI localisation score for likelihood of a mitochondrial

4 Oct 2021: Legend. Integrated Mitochondrial Protein Index (IMPI) [2021Q4pre-20211001]. Sheets:. 1) Table Legend. 2) IMPI All Human Genes (Ensembl): All human genes with annotation, curation and IMPI localisation score. Ensembl Gene ID: Gene identifier for