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  1. Results that match 1 of 2 words

  2. 3Rs Minutes 1st July 2020 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_010720_redacted.pdf
    14 May 2024: Page 1 of 3. Minutes. Date Wednesday, 01/07/2020 Time 08.30am. To Committee Members At Virtual via Microsoft Teams. ... Page 2 of 3. - Mitochondrial diseases: pathogenesis and therapy. • Section 2.1: The committee has noted that for some protocols the
  3. Models of mitochondrial diseases, pathogenesis and therapy

    https://www.ubs.admin.cam.ac.uk/system/files/public/models_of_mitochondrial_diseases_pathogenesis_and_therapy_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:15pm, 25 Apr 2024 Page 3 of 8. Who or what will benefit from these outputs, and how? ... Downloaded: 9:15pm, 25 Apr 2024 Page 7 of 8. Mice will be used to model human mitochondrial diseases.
  4. Mechanisms of organ development and disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_of_organ_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:41pm, 25 Apr 2024 Page 2 of 8. What's the aim of this project? ... Downloaded: 9:41pm, 25 Apr 2024 Page 5 of 8. only possible to fully understand the cellular behaviour during organ development by looking inside an in-tact animal.
  5. Mechanisms controlling cell division and cell identity during…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_controlling_cell_division_and_cell_identity_during_development_reprogramming_and_disease_redacted.pdf
    30 Apr 2024: Downloaded: 9:22pm, 25 Apr 2024 Page 3 of 7. effectively reprogram cells into specific types. ... Downloaded: 9:22pm, 25 Apr 2024 Page 5 of 7. study cell fate most easily and efficiently.
  6. Regulation of the mammalian reproductive axis

    https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_the_mammalian_reproductive_axis._non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:08pm, 25 Apr 2024 Page 6 of 8. objectives, if any. ... Downloaded: 9:08pm, 25 Apr 2024 Page 7 of 8. Which animal models and methods will you use during this project?
  7. Proteotoxicity in development and ageing (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/proteotoxicity_in_development_and_ageing_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:21pm, 25 Apr 2024 Page 2 of 10. What's the aim of this project? ... Downloaded: 9:21pm, 25 Apr 2024 Page 7 of 10. Explain how the numbers of animals for this project were determined.
  8. Nutrient sensing in the brain

    https://www.ubs.admin.cam.ac.uk/system/files/public/nutrient_sensing_in_the_brain_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 8:48pm, 25 Apr 2024 Page 7 of 14. The PPL holder will be required to disclose:. ... Downloaded: 8:48pm, 25 Apr 2024 Page 10 of 14. necessary to allow us to study the disease state.
  9. Understanding Infection Pathogenesis to Guide Therapies…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_infection_pathogenesis_to_guide_therapies_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 2 of 8. Description of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. ... Downloaded: 9:17pm, 25 Apr 2024 Page 6 of 8. Explain how the numbers of animals
  10. Embryonic origins of heart disease

    https://www.ubs.admin.cam.ac.uk/system/files/public/embryonic_origins_of_heart_disease_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:03pm, 25 Apr 2024 Page 2 of 10. What's the aim of this project? ... Downloaded: 9:03pm, 25 Apr 2024 Page 10 of 10. Bedding in the animal holding areas has also been improved.
  11. Interaction between the immune system and tumours (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/interaction_between_the_immune_system_and_tumours_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:43pm, 25 Apr 2024 Page 2 of 8. Description of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. ... Downloaded: 9:43pm, 25 Apr 2024 Page 8 of 8. can take weeks or months not
  12. Understanding the cell biology behind cardiovascular diseases…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_cell_biology_behind_cardiovascular_diseases_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:26pm, 25 Apr 2024 Page 2 of 11. This may include reasons from previous versions of this licence. ... Downloaded: 9:26pm, 25 Apr 2024 Page 8 of 11. The PPL holder will be required to disclose:.
  13. Development of humanised mouse models for study of cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_humanised_mouse_models_for_study_of_cancer_immunotherapy_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:07pm, 25 Apr 2024 Page 2 of 8. Description of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. ... Downloaded: 9:07pm, 25 Apr 2024 Page 7 of 8. 2) Reconstitution of the animals
  14. Platelets as a therapeutic tool

    https://www.ubs.admin.cam.ac.uk/system/files/public/platelets_as_a_therapeutic_tool_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:14pm, 25 Apr 2024 Page 3 of 13. impact on transfusion medicine. ... Downloaded: 9:14pm, 25 Apr 2024 Page 4 of 13. implanted mice will be killed by a Schedule 1 method.
  15. Neurobehavioural Mechanisms Underlying Mood, Impulsive and Compulsive …

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_impulsive_and_compulsive_mental_health_disorders_non-t_redacted.pdf
    30 Apr 2024: Downloaded: 9:20pm, 25 Apr 2024 Page 4 of 8. measurements (e.g. ... Downloaded: 9:20pm, 25 Apr 2024 Page 5 of 8. Early life stress produces extended (i.e.
  16. Breeding and maintenance of rodents for drug discovery platform

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_rodents_for_drug_discovery_platform_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 8:46pm, 25 Apr 2024 Page 3 of 9. drugs further along the drug discovery pipeline. ... Downloaded: 8:46pm, 25 Apr 2024 Page 9 of 9. recorded if there are any signs of ill health.
  17. Developing new mulivalent recombinant vaccines platforms against…

    https://www.ubs.admin.cam.ac.uk/system/files/public/developing_new_multivalent_recombinant_vaccines_platforms_against_infectious_diseases._non-technic_redacted.pdf
    29 Apr 2024: Downloaded: 9:06pm, 25 Apr 2024 Page 5 of 8. Mice:. Mild=96%. ... Downloaded: 9:06pm, 25 Apr 2024 Page 8 of 8. that allows more accurate dosing and reproducibility of results.
  18. Gut hormone modulation of metabolism (non-technical summary)_Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/gut_hormone_modulation_of_metabolism_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:39pm, 25 Apr 2024 Page 4 of 10. Animals used in regulated procedures might need additional modifications before they are assessed. ... Downloaded: 9:39pm, 25 Apr 2024 Page 10 of 10. cages (e.g.
  19. Molecular mechanisms of tolerance and immunosuppression…

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_tolerance_and_immunosuppression_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:24pm, 25 Apr 2024 Page 6 of 11. whole animal context essential. ... Downloaded: 9:24pm, 25 Apr 2024 Page 7 of 11. conducted with adequate statistical power.
  20. 3Rs Minutes 6th January 2021 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_060121_redacted.pdf
    14 May 2024: Page 1 of 3. Minutes. Date Wednesday, 06/01/2021 Time 09.00am. To Committee Members At Virtual via Microsoft Teams. ... Page 3 of 3. 12. Any Other Business. • The committee discussed AWERB 3Rs TOR and the purpose of the meeting. •
  21. Development of Molecular Imaging and Theranostic Agents for Cancer…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_molecular_imaging_and_theranostic_agents_for_cancer_and_inflammation_non-technical_s_redacted.pdf
    30 Apr 2024: Downloaded: 9:17pm, 25 Apr 2024 Page 4 of 9. develop new and/or improved agents in this arena. ... Downloaded: 9:17pm, 25 Apr 2024 Page 9 of 9. (AALAS) American Association for Laboratory Animals Science.
  22. Development of Live Bacterial Therapeutics to treat diseases with…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_to_treat_diseases_with_intestinal_dysbiosis_non-technica_redacted.pdf
    29 Apr 2024: Downloaded: 9:12pm, 25 Apr 2024 Page 5 of 8. What will happen to animals at the end of this project? ... Downloaded: 9:12pm, 25 Apr 2024 Page 7 of 8. Which animal models and methods will you use during this project?
  23. Discovery and development of treatments for immunological diseases

    https://www.ubs.admin.cam.ac.uk/system/files/public/discovery_and_development_of_treatments_for_immunological_diseases_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:04pm, 25 Apr 2024 Page 2 of 8. Objectives and benefitsDescription of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. ... Downloaded: 9:04pm, 25 Apr 2024 Page 4 of 8. compared to
  24. Epigenetic inheritence and the control of developmental and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/epigenetic_inheritance_and_the_control_of_developmental_and_physiological_processes_non-technical_s_redacted.pdf
    30 Apr 2024: Downloaded: 8:59pm, 25 Apr 2024 Page 3 of 10. Who or what will benefit from these outputs, and how? ... Downloaded: 8:59pm, 25 Apr 2024 Page 4 of 10. Mice and zebrafish are used to investigate aspects of our studies.
  25. PK and PKPD studies to support Respiratory and Immunology research

    https://www.ubs.admin.cam.ac.uk/system/files/public/pk_and_pkpd_studies_to_support_respiratory_and_immunology_research_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:08pm, 25 Apr 2024 Page 4 of 8. development is very rapid and animals become sexually mature in a matter of weeks. ... Downloaded: 9:08pm, 25 Apr 2024 Page 5 of 8. What are the expected severities and the proportion of animals in each
  26. Exploring Bioelectronic Approaches to Nervous System Restoration in…

    https://www.ubs.admin.cam.ac.uk/system/files/public/exploring_bioelectronic_approaches_to_nervous_system_restoration_in_large_animals_non-technical_sum_redacted.pdf
    30 Apr 2024: Downloaded: 9:30pm, 25 Apr 2024 Page 2 of 10. The Secretary of State has determined that a retrospective assessment of this licence is notrequired. ... Downloaded: 9:30pm, 25 Apr 2024 Page 6 of 10. Because of these reasons, we need to use animals for our
  27. Mouse developmental genetics to study neurodevelopment and disease…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mouse_developmental_genetics_to_study_neurodevelopment_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:31pm, 25 Apr 2024 Page 3 of 10. regeneration in the human brain. ... Downloaded: 9:31pm, 25 Apr 2024 Page 7 of 10. normal development and disease.
  28. Neurobehavioural Mechanisms Underlying Mood, Anxiety and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_underlying_mood_anxiety_and_stress-related_mental_health_disorders_non_redacted.pdf
    30 Apr 2024: Downloaded: 9:42pm, 25 Apr 2024 Page 2 of 10. Reason for retrospective assessment. ... Downloaded: 9:42pm, 25 Apr 2024 Page 8 of 10. funding at similar levels.
  29. New treatments for renal and liver disease (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatments_for_renal_and_liver_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:29pm, 25 Apr 2024 Page 6 of 11. can receive is limited. ... Downloaded: 9:29pm, 25 Apr 2024 Page 8 of 11. How have you estimated the numbers of animals you will use?
  30. Tissue response following synovial joint injury and potential for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/tissue_response_following_synovial_joint_injury_and_potential_for_therapies_to_restore_joint_structu_redacted.pdf
    30 Apr 2024: Downloaded: 8:57pm, 25 Apr 2024 Page 4 of 8. Typically, what will be done to an animal used in your project? ... Downloaded: 8:57pm, 25 Apr 2024 Page 6 of 8. How have you estimated the numbers of animals you will use?
  31. Ischaemia Reperfusion Injury and Organ Transplantation (non-technical …

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:27pm, 25 Apr 2024 Page 5 of 11. The project will utilise normal wild type or genetically modified mice. ... Downloaded: 9:27pm, 25 Apr 2024 Page 8 of 11. very rare and access to them is very unpredictable.
  32. Pharmacological evaluation of imaging agents and development of…

    https://www.ubs.admin.cam.ac.uk/system/files/public/pharmacological_evaluation_of_imaging_agents_and_development_of_imaging_applications_and_methods_no_redacted.pdf
    30 Apr 2024: Downloaded: 9:45pm, 25 Apr 2024 Page 3 of 11. 2. Biological evaluation. ... Downloaded: 9:45pm, 25 Apr 2024 Page 7 of 11. Non-recovery: 75%.
  33. Control of equine herpesviruses in the horse

    https://www.ubs.admin.cam.ac.uk/system/files/public/control_of_equine_herpesviruses_in_the_horse._non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:01pm, 25 Apr 2024 Page 4 of 11. Unfortunately, the use of ponies for our research is essential. ... Downloaded: 9:01pm, 25 Apr 2024 Page 7 of 11. replicate to reduce the chances having a non-responding blood donor.
  34. The diversity of glia in health, development and disease…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_diversity_of_glia_in_health_development_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:38pm, 25 Apr 2024 Page 2 of 11. Contains severe procedures. ... Downloaded: 9:38pm, 25 Apr 2024 Page 9 of 11. is on understanding adult mechanisms.
  35. Potent monoclonal antibodies for biologics discovery (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/potent_monoclonal_antibodies_for_biologics_discovery_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:46pm, 25 Apr 2024 Page 6 of 12. Mild severity - 100%. ... Downloaded: 9:46pm, 25 Apr 2024 Page 9 of 12. the 5-year license period.
  36. Development of nerve neuroprosthetic treatment

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_nerve_neuroprosthetic_treatments_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:06pm, 25 Apr 2024 Page 8 of 12. ex vivo systems in studying long-term interactions. ... Downloaded: 9:06pm, 25 Apr 2024 Page 12 of 12. use of training protocols for each procedure.
  37. Development of novel therapeutics for pain (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_novel_therapeutics_for_pain_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:43pm, 25 Apr 2024 Page 3 of 11. conditions and validate our targets. ... Downloaded: 9:43pm, 25 Apr 2024 Page 5 of 11. and analysis to determine any biological effects.
  38. 3Rs Minutes 7th October 2020 Redacted

    https://www.ubs.admin.cam.ac.uk/system/files/public/3rs_minutes_071020_redacted.pdf
    14 May 2024: Page 1 of 3. Minutes. Date Wednesday, 07/10/2020 Time 08.30am. To Committee Members At Virtual via Microsoft Teams. ... 3Rs information/reports. Page 3 of 3. 9. Feedback from previous Retrospective Reviews None.
  39. Multi-tissue mechanics in the development and engineering of the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/multi-tissue_mechanics_in_the_development_and_engineering_of_the_posterior_body_axis_non-technical_redacted.pdf
    30 Apr 2024: Downloaded: 9:40pm, 25 Apr 2024 Page 2 of 9. What's the aim of this project? ... Downloaded: 9:40pm, 25 Apr 2024 Page 6 of 9. dish (in vitro).
  40. The development of in vivo expressed biologics as a platform for…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_in_vivo_expressed_biologics_as_a_platform_for_novel_therapeutic_agents_non-techn_redacted.pdf
    30 Apr 2024: Downloaded: 9:23pm, 25 Apr 2024 Page 3 of 8. Who or what will benefit from these outputs, and how? ... Downloaded: 9:23pm, 25 Apr 2024 Page 4 of 8. the sexes kept apart in their groups of 3-5 animals.
  41. Understanding the roles of autophagy and related pathways in…

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_the_roles_of_autophagy_and_related_pathways_in_proteinopathies_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:11pm, 25 Apr 2024 Page 3 of 11. Who or what will benefit from these outputs, and how? ... Downloaded: 9:11pm, 25 Apr 2024 Page 4 of 11. Our choice of species for this licence is mice.
  42. Vaccine development and fundamental reseach on viruses of medical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/vaccine_development_and_fundamental_research_on_viruses_of_medical_importance_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:20pm, 25 Apr 2024 Page 2 of 12. Animal types Life stages. ... Downloaded: 9:20pm, 25 Apr 2024 Page 5 of 12. observed for a period of up to 14 days.
  43. Early life origins of heart disease in mammals (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/early_life_origins_of_heart_disease_in_mammals_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:25pm, 25 Apr 2024 Page 3 of 12. in different vessels (e.g. ... Downloaded: 9:25pm, 25 Apr 2024 Page 5 of 12. subsequent molecular studies).
  44. The development of novel therapies (including cell and gene based…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_development_of_novel_therapies_including_cell_and_gene_based_approaches_for_parkinsons_and_hu_redacted.pdf
    30 Apr 2024: Downloaded: 9:47pm, 25 Apr 2024 Page 7 of 10. Which non-animal alternatives did you consider for use in this project? ... Downloaded: 9:47pm, 25 Apr 2024 Page 8 of 10. To minimise animal usage, we will:.
  45. Investigating the niche of mucosal parasitic nematodes and their…

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_niche_of_mucosal_parasitic_nematodes_and_their_interactions_with_their_hosts_non_redacted.pdf
    30 Apr 2024: Downloaded: 9:19pm, 25 Apr 2024 Page 11 of 12. - Carefully consider needle gauge, and keeping volumes and doses to the minimum necessary, for injection of substances. - ... Downloaded: 9:19pm, 25 Apr 2024 Page 12 of 12. RSPCA website: http://science.rspca
  46. Metabolic basis of microglia function in development (non-technical…

    https://www.ubs.admin.cam.ac.uk/system/files/public/metabolic_basis_of_microglia_function_in_development_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:28pm, 25 Apr 2024 Page 2 of 13. Reason for retrospective assessment. ... Downloaded: 9:28pm, 25 Apr 2024 Page 4 of 13. Who or what will benefit from these outputs, and how?
  47. Genes and environment at the interface of inflammation, immunity and…

    https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_environment_at_the_interface_of_inflammation_immunity_and_metabolism_non-technical_summa_redacted.pdf
    30 Apr 2024: Downloaded: 9:02pm, 25 Apr 2024 Page 2 of 11. What's the aim of this project? ... Downloaded: 9:02pm, 25 Apr 2024 Page 7 of 11. mouse the most appropriate model system.
  48. The genetic and developmental basis of morphological and behavioural…

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_genetic_and_developmental_basis_of_morphological_and_behavioural_variation_in_cichlid_fishes_no_redacted.pdf
    30 Apr 2024: Downloaded: 9:46pm, 25 Apr 2024 Page 6 of 11. dividers will have holes where females can go through. ... Downloaded: 9:46pm, 25 Apr 2024 Page 7 of 11. we do not expect this protocol to induce any suffering, harm or distress.
  49. Determining mechanisms of tumour development and relapse following…

    https://www.ubs.admin.cam.ac.uk/system/files/public/determining_mechanisms_of_tumour_development_and_relapse_following_treatment_non-technical_summary_redacted.pdf
    29 Apr 2024: Downloaded: 9:12pm, 25 Apr 2024 Page 7 of 11. Which non-animal alternatives did you consider for use in this project? ... Downloaded: 9:12pm, 25 Apr 2024 Page 11 of 11. randomly assigned to treatment groups and attempts will be made to blind studies.
  50. Provision of an outsourced drug discovery platform for the…

    https://www.ubs.admin.cam.ac.uk/system/files/public/provision_of_an_outsourced_drug_discovery_platform_for_the_development_of_therapeutic_drugs_for_neur_redacted.pdf
    30 Apr 2024: Downloaded: 9:00pm, 25 Apr 2024 Page 3 of 10. needs for treatments. ... Downloaded: 9:00pm, 25 Apr 2024 Page 9 of 10. costs (harms) to the animals.
  51. Mechanisms underpinning neuronal excitability in health and disease…

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_underpinning_neuronal_excitability_in_health_and_disease_non-technical_summary_redacted.pdf
    30 Apr 2024: Downloaded: 9:26pm, 25 Apr 2024 Page 8 of 14. Why do you need to use animals to achieve the aim of your project? ... Downloaded: 9:26pm, 25 Apr 2024 Page 10 of 14. Overall numbers have been estimated based upon two key factors:. •

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