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  2. PPL Course Content | University Biomedical Services (UBS)

    https://www.ubs.admin.cam.ac.uk/training-centre/ppl-course/ppl-course-content
    23 Jun 2021: All new potential PPL applicants/holders should be aware there is a requirement for you to complete the relevant PIL course for the work you intend to perform in your project licence. This is only the case if you are not already a PIL holder. PPL
  3. PIL Course content | University Biomedical Services (UBS)

    https://www.ubs.admin.cam.ac.uk/training-centre/pil-course/pil-course-content
    23 Jun 2021: Course Content PIL Course A Elements 1. Legislation. 2. Ethics and animal welfare. 3. Biology and husbandry of relevant species. 4. Handling and restraint of relevant species. 5. Animal care and management. 6. Recognition of wellbeing, pain,
  4. Train the Trainer Course dates | University Biomedical Services (UBS)

    https://www.ubs.admin.cam.ac.uk/training-centre/train-trainer-course/train-trainer-course-dates
    23 Jun 2021: 2024 Train the Trainer Course dates Month Deadline Access to the online course material Format Live/in person session January 22nd December 2nd January Online 9th January April 22nd March 1st April In person 10th April June 17th May 28th May
  5. Nominated Assessors Course dates | University Biomedical Services…

    https://www.ubs.admin.cam.ac.uk/training-centre/nominated-assessors-course/nominated-assessors-course-dates
    23 Jun 2021: 2024 Nominated Assessor Course dates Month Deadline Access to the online course material Format Live/in person session February 2nd February 12th February Online 19th February April 28th March 8th April In person 16th April June 24th May 3rd June
  6. PPL number: | Granted: 30 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_regulation_of_fertility_nts_expires2024_redacted.pdf
    13 Sep 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Neural regulation of fertility. Project duration. ... Page 2 of 4. The project aims to understand how a specific group of brain cells work together to control fertility.
  7. PPL number: | Granted: 06 Jan 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/support_procedures_for_neural_repair_nts_redacted.pdf
    19 Aug 2021: Page 6 of 8. Explain how the numbers of animals for this project were determined. ... Page 7 of 8. Most of the animals used in this licence have no adverse phenotypes.
  8. AWERB Standing Committee Redacted Minutes. | University Biomedical…

    https://www.ubs.admin.cam.ac.uk/animal-welfare-ethical-review-body/awerb-redacted-minutes/awerb-standing-committee-redacted-minutes
    12 Oct 2021: Search site. University Biomedical Services (UBS). AWERB Standing Committee Redacted Minutes. 2019 AWERB Standing Committee Redacted Minutes. awerb_standing_minutes_300119_redacted.pdf (75.22 KB). awerb_standing_minutes_270219_redacted.pdf (84.18 KB)
  9. PPL number: | Granted: 07 Aug 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/microglial_targets_in_brain_pathology_and_ageing_nts_redacted.pdf
    20 Aug 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Microglial targets in brain pathology and ageing. ... Page 3 of 4. monitoring system to make sure that mice do not develop marked disability/disease before being humanely killed.
  10. Service Technician and Support Staff course dates | University…

    https://www.ubs.admin.cam.ac.uk/training-centre/service-technician-and-support-staff-development-course/service-technician-and
    23 Jun 2021: 2024 Service and Support Staff Course dates Month Deadline Access to the online course material Format Live session April 5th April 8th April In person 23rd April Additional dates can be arranged for sufficient numbers of attendees, either in
  11. PPL number: | Granted: 04 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_study_of_epithelial_cancer_genes_nts_expires2022_redacted.pdf
    13 Sep 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. The study of epithelial cancer genes. ... Page 4 of 4. 3) Statisticians have been consulted on experimental design to minimise the number of animals used whilst still obtaining meaningful results.
  12. PPL number: | Granted: 06 Aug 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/mice_with_transgenic_immunoglobulin_loci_nts_redacted.pdf
    20 Aug 2021: Page 2 of 6. What's the aim of this project? Our pets are currently getting sick from the same conditions that we do, and that we can successfully treat in ... Page 5 of 6. The stem cells we use will be extensively pre-screened to make sure we only use
  13. PPL number: | Granted: 24 Feb 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/maternal_and_neonatal_immunity_to_virus_infections_redacted.pdf
    18 Jun 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Maternal and neonatal immunity to virusinfections. ... Page 5 of 8. study the effects of viruses and antibodies on a single cell level.
  14. PPL number: | Granted: 18 Feb 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/protection_after_heart_attack_or_stroke_nts_redacted.pdf
    19 Aug 2021: Page 1 of 9. NON-TECHNICAL SUMMARY. Protection after heart attack or stroke. ... Page 6 of 9. Which non-animal alternatives did you consider for use in this project?
  15. PPL number: | Granted: 03 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regeneration_in_the_nervous_system_nts_expires2024_redacted.pdf
    13 Sep 2021: Page 2 of 6. Description of the project’s objectives, for example the scientific unknowns or clinical orscientific needs it’s addressing. ... Page 4 of 6. What harms were caused to the animals, how severe were those harms and how many animalswere
  16. PPL number: | Granted: 01 Dec 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/radiation_combinations_for_cancer_treatment_nts_redacted.pdf
    19 Aug 2021: Page 3 of 9. Dissemination of knowledge at conferences via poster sessions and seminars. ... Laboratory Animals Volume: 52 issue: 2, page(s): 135-141. LASA Guiding Principles.
  17. PPL number: | Granted: 18 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/generation_of_novel_antibodies_with_therapeutic_potential_nts_redacted.pdf
    20 Aug 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Generation of novel antibodies with therapeuticpotential. ... Page 3 of 4. manipulation. The second largest group of mice (1500) represent those that form the breeding colony.
  18. PPL number: | Granted: 31 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/enteroendocrine_signalling_in_health_and_disease_nts_expires2024_redacted.pdf
    13 Sep 2021: Page 2 of 5. Objectives and benefitsDescription of the project’s objectives, for example the scientific unknowns or clinical orscientific needs it’s addressing. ... Page 4 of 5. be taken and stored from animals having undergone these surgical
  19. PPL number: | Granted: 21 Jan 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_long-term_effects_of_developmental_hypoxia_on_cardiac_function_nts_redacted.pdf
    19 Aug 2021: Page 1 of 5. NON-TECHNICAL SUMMARY. The long-term effects of developmentalhypoxia on cardiac function. ... Page 5 of 5. Zebrafish are extremely hypoxia tolerant, so we do not expect any adverse effects from hypoxia exposure.
  20. PPL number: | Granted: 28 Oct 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_how_neutrophil_migration_behaviour_is_fine-tuned_during_inflammation_nts_redacted.pdf
    20 Aug 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Understanding how neutrophil migrationbehaviour is fine-tuned during inflammation. ... Page 4 of 4. RefinementExplain the choice of species and why the animal model(s) you will use are the most refined,having regard to
  21. PPL number: | Granted: 20 Aug 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/training_in_advanced_or_complex_procedures_or_devices_nts_redacted.pdf
    13 Sep 2021: Page 1 of 7. NON-TECHNICAL SUMMARY. Training in advanced or complex procedures ordevices. ... Page 3 of 7. What are the principal learning outcomes from the course?
  22. PPL number: | Granted: 05 Oct 17 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/regulation_of_embryonic_lineages_and_stem_cells_nts_expires2022_redacted.pdf
    13 Sep 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Regulation of embryonic lineages and stemcells. ... Page 3 of 4. should they form, will be allowed to cause more than minimal discomfort.
  23. PPL number: | Granted: 29 Jan 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/new_treatment_strategies_for_myocardial_infarction_and_aortic_aneurysm_nts_expires2024_redacted.pdf
    13 Sep 2021: Page 1 of 5. NON-TECHNICAL SUMMARY. New treatment strategies for myocardialinfarction and aortic aneurysm. ... Page 3 of 5. Approximately 8600 mice and 650 rats over 5 years.
  24. PPL number: | Granted: 16 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neurobehavioural_mechanisms_of_mental_health_nts_expires2023_redacted.pdf
    13 Sep 2021: Page 1 of 5. NON-TECHNICAL SUMMARY. Neurobehavioural Mechanisms of MentalHealth. Project duration. ... Page 3 of 5. The specific research questions that each experiment aims to address will determine the types of procedures that are experienced by the
  25. PPL number: | Granted: 26 Nov 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/ischaemia_reperfusion_injury_and_organ_transplantation_nts_redacted.pdf
    19 Aug 2021: Page 2 of 7. Description of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing. ... Page 5 of 7. Why do you need to use animals to achieve the aim of your project?
  26. PPL number: | Granted: 24 May 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_mechanisms_of_neuronal_excitation_and_neuroinflammation_nts_expires2023_redacted.pdf
    13 Sep 2021: Page 1 of 5. NON-TECHNICAL SUMMARY. Molecular Mechanisms of Neuronal Excitationand Neuroinflammation. ... Page 2 of 5. What's the aim of this project? The nervous system is important for normal bodily function.
  27. PPL number: | Granted: 20 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/neural_basis_of_spatial_cognition_and_memory_in_the_hippocampus_nts_redacted.pdf
    20 Aug 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Neural basis of spatial cognition and memoryin the hippocampus. ... Page 4 of 4. Explain how you will assure the use of minimum numbers of animals.
  28. PPL number: | Granted: 10 Apr 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genetic_and_developmental_basis_of_morphological_variation_in_cichlid_fish_nts_expires2024_redacted.pdf
    13 Sep 2021: Page 1 of 5. NON-TECHNICAL SUMMARY. Genetic and developmental basis ofmorphological variation in cichlid fish. ... Page 2 of 5. Cichlids are a very diverse group of 2100 fish species, with very distinct colour patterns.
  29. PPL number: | Granted: 19 Jun 18 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genetically_engineered_mouse_models_of_cancer_nts_expires2023_redacted.pdf
    13 Sep 2021: Page 4 of 5. latest developments by attending conferences and monitoring websites, such as pubmed, for the latest advances. ... Page 5 of 5. One method is classically used in the literature, whereby mice are bred and aged, eventually developing specific
  30. PPL number: | Granted: 22 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_and_maintenance_of_germ_free_and_gnotobiotic_animals_service_licence_nts_redacted.pdf
    13 Sep 2021: Page 1 of 7. NON-TECHNICAL SUMMARY. Breeding and maintenance of germ free andgnotobiotic animals service licence. ... Page 6 of 7. This will subsequently help to reduce the number of animals required for this project.
  31. PPL number: | Granted: 28 Jul 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/developing_anti-malarial_transmission_blocking_interventions_nts_redacted.pdf
    13 Sep 2021: Page 1 of 9. NON-TECHNICAL SUMMARY. Developing anti-malarial transmission blockinginterventions. Project duration. ... Page 5 of 9. When immunising mice, transient pain at injection site may occur.
  32. PPL number: | Granted: 23 Oct 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_novel_strategies_for_bone_repair_nts_redacted.pdf
    19 Aug 2021: Page 1 of 9. NON-TECHNICAL SUMMARY. Evaluation of Novel Strategies for Bone Repair. ... Page 9 of 9. Assessment and Accreditation of Laboratory Care International (AAALAC International).
  33. PPL number: | Granted: 25 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/circuit_mechanisms_of_learning_and_memory_in_the_mammalian_brain_redacted.pdf
    18 Jun 2021: Page 7 of 8. Which animal models and methods will you use during this project? ... Page 8 of 8. 2. To the extent possible, we will co-house animals.
  34. PPL number: | Granted: 12 Feb 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/promoting_proliferation_in_non-regenerative_tissues_redacted.pdf
    18 Jun 2021: Page 1 of 11. NON-TECHNICAL SUMMARY. Promoting proliferation in non-regenerativetissues. Project duration. ... Page 10 of 11. Staff will be trained and become experienced in surgery.
  35. PPL number: | Granted: 12 Jul 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/understanding_pathogen_behaviour_in_relation_to_the_immunity_vaccines_and_antibiotic_treatment_nts_expires2022_redacted.pdf
    13 Sep 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Understanding pathogen behaviour in relationto the immunity, vaccines and antibiotictreatment. ... Page 3 of 4. Typical procedures done to animals, for example injections or surgical procedures, includingduration of
  36. PPL number: | Granted: 18 Nov 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/papillomavirus_transmission_infection_and_lesion_formation_nts_redacted.pdf
    19 Aug 2021: Page 5 of 9. After virus infection, animals will receive reagents or treatment (e.g. ... Page 8 of 9. Which animal models and methods will you use during this project?
  37. PPL number: | Granted: 25 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_pathobiology_and_therapeutic_opportunities_of_ubiquitin_ligases_nts_redacted.pdf
    13 Sep 2021: Page 1 of 7. NON-TECHNICAL SUMMARY. Investigating the pathobiology and therapeuticopportunities of ubiquitin ligases. ... Page 7 of 7. Why can’t you use animals that are less sentient?
  38. PPL number: | Granted: 30 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/genes_and_mechanisms_involved_in_genome_regulation_nts_redacted.pdf
    13 Sep 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Genes and mechanisms involved in genomeregulation. ... Page 3 of 8. to benefit from the data, and to reproduce results and interpretations.
  39. PPL number: | Granted: 19 Nov 19 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/breeding_of_transgenic_rodents_for_supply_of_tissues_to_the_client_nts_redacted.pdf
    20 Aug 2021: Page 7 of 11. Guidance on the Breeding of GA Animals (NC3Rs Website). ... Page 8 of 11. PPL number: | Granted: 19 Nov 19 | Expires: 19 Nov 24.
  40. PPL number: | Granted: 21 Aug 19 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_humoral_immunity_in_tissue-specific_immune_responses_in_health_and_disease_redacted.pdf
    20 Aug 2021: Page 1 of 4. NON-TECHNICAL SUMMARY. Investigating the role of humoral immunity intissue-specific immune responses in healthand disease. ... Page 3 of 4. Typical procedures done to animals, for example injections or surgical procedures, includingduration
  41. PPL number: | Granted: 17 Feb 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/roles_for_genomic_instability_in_cancer_and_ageing_redacted.pdf
    18 Jun 2021: Page 1 of 10. NON-TECHNICAL SUMMARY. ROLES FOR GENOMIC INSTABILITY INCANCER AND AGEING. ... Page 3 of 10. New genes of interest will be identified and described.
  42. PPL number: | Granted: 13 Jan 20 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/molecular_and_genetic_regulation_of_glial_development_and_function_nts_redacted.pdf
    19 Aug 2021: Page 1 of 7. NON-TECHNICAL SUMMARY. Molecular and Genetic Regulation of GlialDevelopment and Function. ... Page 5 of 7. How have you estimated the numbers of animals you will use?
  43. PPL number: | Granted: 25 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/circuit_mechanisms_of_learning_and_memory_in_the_mammalian_brain_nts_expires2026_redacted.pdf
    13 Sep 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Circuit mechanisms of learning and memory inthe mammalian brain. ... Moreover, our institution's web pages provide regular updates on new developments in the 3Rs.
  44. PPL number: | Granted: 01 Apr 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/evaluation_of_new_devices_to_be_used_in_human_surgery_nts_redacted.pdf
    20 Aug 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Evaluation of new devices to be used in humansurgery. ... Page 6 of 8. effect in as 'human-like' an environment as possible.
  45. PPL number: | Granted: 05 May 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/safety_efficacy_and_immunogenicity_of_regenerative_cellular_therapies_redacted.pdf
    18 Jun 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Safety, efficacy and immunogenicity ofregenerative cellular therapies. ... Page 2 of 8. Description of the projects objectives, for example the scientific unknowns or clinical orscientific needs it's addressing.
  46. PPL number: | Granted: 24 May 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_influencing_mammalian_digit_tip_regeneration_redacted.pdf
    18 Jun 2021: Page 4 of 10. Explain why you are using these types of animals and your choice of life stages. ... Page 8 of 10. This project will use mice to study the naturally occurring process of digit tip regrowth.
  47. PPL number: | Granted: 09 Sep 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/development_of_live_bacterial_therapeutics_for_the_treatment_of_cancer_nts_redacted.pdf
    13 Sep 2021: Page 1 of 8. NON-TECHNICAL SUMMARY. Development of Live Bacterial Therapeutics forthe treatment of cancer. ... Page 7 of 8. Which animal models and methods will you use during this project?
  48. PPL number: | Granted: 22 Jun 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/impact_of_sensory_and_electrical_activity_on_neuronal_function_nts_redacted.pdf
    13 Sep 2021: Page 1 of 10. NON-TECHNICAL SUMMARY. Impact of sensory and electrical activity onneuronal function. ... Page 5 of 10. Moderate: 8%. What will happen to animals at the end of this project?
  49. PPL number: | Granted: 04 Mar 21 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/mechanisms_and_treatment_of_pulmonary_vascular_diseases_redacted.pdf
    18 Jun 2021: Page 1 of 11. NON-TECHNICAL SUMMARY. Mechanisms and treatment of pulmonaryvascular diseases. ... Page 3 of 11. Who or what will benefit from these outputs, and how?
  50. PPL number: | Granted: 24 Sep 20 | Amended: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/investigating_the_role_of_physical_cues_in_nervous_system_function_in_wild_type_and_transgenic_anima_redacted.pdf
    19 Aug 2021: Page 3 of 5. What types and approximate numbers of animals will you use over the course of this project? ... Page 4 of 5. used requires a surgery this can affect the health and welfare of the animal.
  51. PPL number: | Granted: 09 Sep 21 | Expires: ...

    https://www.ubs.admin.cam.ac.uk/system/files/public/the_integrated_stress_response_in_respiratory_disease_nts_redacted.pdf
    13 Sep 2021: Page 1 of 11. NON-TECHNICAL SUMMARY. The integrated stress response in respiratorydisease. ... Page 4 of 11. Some patients develop pulmonary hypertension because of mutations in certain genes.

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