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1 - 10 of 1,156 search results for p53

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  2. p53 impairs CRISPR/Cas9 in healthy cells | Department of Biochemistry

    https://www.bioc.cam.ac.uk/news/archive/2018/p53-impairs-crispr-cas9-in-healthy-cells
    13 Jun 2024: RPE-1) cell line activate p53, causing cell growth arrest and DNA repair via the NHEJ pathway. ... A delicate balance is required, however, as p53 inhibition can leave cells vulnerable to tumorigenic mutations.

  3. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

  4. Professor Sir Alan Fersht FRS | Yusuf Hamied Department of Chemistry

    https://www.ch.cam.ac.uk/person/arf25
    12 Jun 2024: Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: The Y220X Paradigm. ... doi:A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.

  5. Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-231
    Reference: P53/43/231. Reference: P53/43/231. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

  6. Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-262
    Reference: P53/43/262. Reference: P53/43/262. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

  7. Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-388
    Reference: P53/43/388. Reference: P53/43/388. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930).

  8. Freeze Frame » Coast from Umivik to the south-west corner of…

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-497
    Reference: P53/43/497. Reference: P53/43/497. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931).

  9. Freeze Frame » Coast from Umivik to the south-west corner of…

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-540
    Reference: P53/43/540. Reference: P53/43/540. Title: Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931).

  10. Freeze Frame » Coast from Kangerdlugssuatsiaq to Kialineq (18 August …

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-278
    Reference: P53/43/278. Reference: P53/43/278. Title: Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).

  11. Freeze Frame » Coast from Long Island to Kangerdlugssuaq (20 August…

    https://www.freezeframe.ac.uk/collection/photos-british-arctic-air-route-expedition-1930-31/p53-43-424
    Reference: P53/43/424. Reference: P53/43/424. Title: Coast from Long Island to Kangerdlugssuaq (20 August 1930).

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