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Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/merkle23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation -
Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute
https://www.stemcells.cam.ac.uk/people/affiliates/christophorou23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation. -
Emeritus - MRC Laboratory of Molecular Biology
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.
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https://www.pdn.cam.ac.uk/taxonomy/term/58/feed
https://www.pdn.cam.ac.uk/taxonomy/term/58/feed1 Jul 2024: b>. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/1/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/3/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/4/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/5/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/6/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/7/2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator. -
Dr Suzanne Dawn Turner | Cambridge Immunology Network
https://www.immunology.cam.ac.uk/Networkdirectory/sdturner23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the -
Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …
https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/9You are logged on as '':username. password. -
Scheres lab
https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA". -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09300/0/InterPro (2). 1.8. hapstr1. HUWE1-associated protein modifying stress responses (Telomere. attrition and p53 response 1 protein). ... Telomere attrition and p53 response 1 protein). None. GO (7). EMBL (2). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/10You are logged on as '':username. password. -
Member: Florian Merkle - Cambridge Neuroscience
https://neuroscience.cam.ac.uk/member/florianmerkle/My later work in human pluripotent stem cell (hPSC) genomics provided open-access resources for rational cell line selection, revealed recurrent mutations in p53 that profoundly impacted the fields of stem ... Human pluripotent stem cells recurrently -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/0/regulation of signal transduction by p53 class mediator. -
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/2623 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status" -
Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…
https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.
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Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/105You are logged on as '':username. password. -
Robert Lamplough Mann, Lieutenant, 7th Dragoon Guards | Jesus College …
https://www.jesus.cam.ac.uk/robert-lamplough-mann-lieutenant-7th-dragoon-guards30 Jun 2024: Mann was originally thought to have been wounded on 29 December 1914 and was recorded as a prisoner of war on 25 March 1915 (Jesus College Society Annual Report, 1916, p53).
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Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/1/None. GO (21). InterPro (2). 2.9. fk24g11. P53 apoptosis effector related to. ... PMP-22 (P53 apoptosis effector-related to pmp22). None. GO (6). EMBL (1). -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/3/InterPro (1). 0.0. P53 apoptosis effector related to PMP22. None. GO (6). ... GO (12). InterPro (2). 0.0. PERP. P53 apoptosis effector related to PMP22. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/4/EMBL (2). InterPro (2). 0.0. P53 apoptosis effector related to PMP-22. ... InterPro (2). 0.0. P53 apoptosis effector related to PMP22. None. GO (3). -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/5/GO (3). InterPro (2). 0.0. P53 apoptosis effector related to PMP-22. ... GO (4). InterPro (1). 0.0. PERP. P53 apoptosis effector related to PMP22. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/6/1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW). None. GO (18). ... EMBL (12). InterPro (2). 0.0. PERP. P53 apoptosis effector related to PMP22. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/7/0.0. P53 apoptosis effector related to PMP22. None. GO (3). EMBL (2). ... InterPro (1). 0.0. P53 apoptosis effector related to PMP22. None. GO (6). -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP01517/negative regulation of DNA damage response, signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09958/InterPro (5). 0.5. ZMAT3. Zinc finger matrin-type protein 3 (Zinc. finger protein WIG-1) (p53-activated gene 608 protein). ... protein) (Zinc finger protein WIG-1) (p53-activated gene 608 protein). None. GO (13). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/14?x=x&slideshow=1Freeze Frame —P53/43/250 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/254 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/15?x=x&slideshow=1Freeze Frame —P53/43/280 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/285 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/16?x=x&slideshow=1Freeze Frame —P53/43/221 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/278 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/17?x=x&slideshow=1Freeze Frame —P53/43/265 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/281 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/18?x=x&slideshow=1Freeze Frame —P53/43/255 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/231 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/19?x=x&slideshow=1Freeze Frame —P53/43/247 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/282 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/20?x=x&slideshow=1Freeze Frame —P53/43/458 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/404 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/21?x=x&slideshow=1Freeze Frame —P53/43/394 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/414 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/22?x=x&slideshow=1Freeze Frame —P53/43/412 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/454 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/23?x=x&slideshow=1Freeze Frame —P53/43/415 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/448 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/24?x=x&slideshow=1Freeze Frame —P53/43/418 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/453 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/25?x=x&slideshow=1Freeze Frame —P53/43/410 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/459 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/26?x=x&slideshow=1Freeze Frame —P53/43/483 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/469 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931) -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/27?x=x&slideshow=1Freeze Frame —P53/43/510 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/503 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931) -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/28?x=x&slideshow=1Freeze Frame —P53/43/466 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/480 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931) -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/29?x=x&slideshow=1Freeze Frame —P53/43/482 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/502 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931) -
Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31
https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/30?x=x&slideshow=1Freeze Frame —P53/43/511 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931). ... full information on this image ». P53/43/529 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931) -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/1/regulation of signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/3/regulation of signal transduction by p53 class mediator. -
Unknome v3
https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/4/regulation of signal transduction by p53 class mediator.
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