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  2. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation
  3. Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/christophorou
    23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation.
  4. Emeritus - MRC Laboratory of Molecular Biology

    https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/
    Thumbnail for Emeritus - MRC Laboratory of Molecular Biology 21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.
  5. https://www.pdn.cam.ac.uk/taxonomy/term/58/feed

    https://www.pdn.cam.ac.uk/taxonomy/term/58/feed
    1 Jul 2024: b>. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis.
  6. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/1/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  7. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/3/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  8. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/4/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  9. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/5/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  10. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/6/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  11. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09493/7/
    2023). Molecular function: positive regulation of DNA damage response, signal transduction by p53 class mediator.
  12. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the
  13. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells
  14. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/9
    You are logged on as '':username. password.
  15. Scheres lab

    https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html
    3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".
  16. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09300/0/
    InterPro (2). 1.8. hapstr1. HUWE1-associated protein modifying stress responses (Telomere. attrition and p53 response 1 protein). ... Telomere attrition and p53 response 1 protein). None. GO (7). EMBL (2).
  17. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/10
    You are logged on as '':username. password.
  18. Member: Florian Merkle - Cambridge Neuroscience

    https://neuroscience.cam.ac.uk/member/florianmerkle/
    My later work in human pluripotent stem cell (hPSC) genomics provided open-access resources for rational cell line selection, revealed recurrent mutations in p53 that profoundly impacted the fields of stem ... Human pluripotent stem cells recurrently
  19. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/0/
    regulation of signal transduction by p53 class mediator.
  20. https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
    23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status"
  21. Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…

    https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/
    Thumbnail for Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular Biology 20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.
  22. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/105
    You are logged on as '':username. password.
  23. Robert Lamplough Mann, Lieutenant, 7th Dragoon Guards | Jesus College …

    https://www.jesus.cam.ac.uk/robert-lamplough-mann-lieutenant-7th-dragoon-guards
    Thumbnail for Robert Lamplough Mann, Lieutenant, 7th Dragoon Guards | Jesus College in the University of Cambridge 30 Jun 2024: Mann was originally thought to have been wounded on 29 December 1914 and was recorded as a prisoner of war on 25 March 1915 (Jesus College Society Annual Report, 1916, p53).
  24. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/1/
    None. GO (21). InterPro (2). 2.9. fk24g11. P53 apoptosis effector related to. ... PMP-22 (P53 apoptosis effector-related to pmp22). None. GO (6). EMBL (1).
  25. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/3/
    InterPro (1). 0.0. P53 apoptosis effector related to PMP22. None. GO (6). ... GO (12). InterPro (2). 0.0. PERP. P53 apoptosis effector related to PMP22.
  26. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/4/
    EMBL (2). InterPro (2). 0.0. P53 apoptosis effector related to PMP-22. ... InterPro (2). 0.0. P53 apoptosis effector related to PMP22. None. GO (3).
  27. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/5/
    GO (3). InterPro (2). 0.0. P53 apoptosis effector related to PMP-22. ... GO (4). InterPro (1). 0.0. PERP. P53 apoptosis effector related to PMP22.
  28. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/6/
    1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW). None. GO (18). ... EMBL (12). InterPro (2). 0.0. PERP. P53 apoptosis effector related to PMP22.
  29. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP07752/7/
    0.0. P53 apoptosis effector related to PMP22. None. GO (3). EMBL (2). ... InterPro (1). 0.0. P53 apoptosis effector related to PMP22. None. GO (6).
  30. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP01517/
    negative regulation of DNA damage response, signal transduction by p53 class mediator.
  31. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP09958/
    InterPro (5). 0.5. ZMAT3. Zinc finger matrin-type protein 3 (Zinc. finger protein WIG-1) (p53-activated gene 608 protein). ... protein) (Zinc finger protein WIG-1) (p53-activated gene 608 protein). None. GO (13).
  32. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/14?x=x&slideshow=1
    Freeze Frame —P53/43/250 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/254 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  33. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/15?x=x&slideshow=1
    Freeze Frame —P53/43/280 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/285 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  34. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/16?x=x&slideshow=1
    Freeze Frame —P53/43/221 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/278 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  35. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/17?x=x&slideshow=1
    Freeze Frame —P53/43/265 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/281 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  36. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/18?x=x&slideshow=1
    Freeze Frame —P53/43/255 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/231 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  37. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/19?x=x&slideshow=1
    Freeze Frame —P53/43/247 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930). ... full information on this image ». P53/43/282 (1930). Coast from Kangerdlugssuatsiaq to Kialineq (18 August 1930).
  38. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/20?x=x&slideshow=1
    Freeze Frame —P53/43/458 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/404 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  39. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/21?x=x&slideshow=1
    Freeze Frame —P53/43/394 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/414 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  40. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/22?x=x&slideshow=1
    Freeze Frame —P53/43/412 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/454 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  41. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/23?x=x&slideshow=1
    Freeze Frame —P53/43/415 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/448 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  42. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/24?x=x&slideshow=1
    Freeze Frame —P53/43/418 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/453 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  43. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/25?x=x&slideshow=1
    Freeze Frame —P53/43/410 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930). ... full information on this image ». P53/43/459 (1930). Coast from Long Island to Kangerdlugssuaq (20 August 1930).
  44. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/26?x=x&slideshow=1
    Freeze Frame —P53/43/483 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/469 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931)
  45. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/27?x=x&slideshow=1
    Freeze Frame —P53/43/510 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/503 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931)
  46. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/28?x=x&slideshow=1
    Freeze Frame —P53/43/466 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/480 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931)
  47. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/29?x=x&slideshow=1
    Freeze Frame —P53/43/482 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931). ... full information on this image ». P53/43/502 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (20 July 1931)
  48. Freeze Frame » Photos: British Arctic Air Route Expedition 1930-31

    https://www.freezeframe.ac.uk/category/photos-british-arctic-air-route-expedition-1930-31/page/30?x=x&slideshow=1
    Freeze Frame —P53/43/511 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931). ... full information on this image ». P53/43/529 (1931). Coast from Umivik to the south-west corner of Angmagssalik Island (22 July 1931)
  49. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/1/
    regulation of signal transduction by p53 class mediator.
  50. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/3/
    regulation of signal transduction by p53 class mediator.
  51. Unknome v3

    https://unknome.mrc-lmb.cam.ac.uk/cluster_details/UKP04148/4/
    regulation of signal transduction by p53 class mediator.

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