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2 Jul 2024: doi: 10.1007/s11538-009-9479-6). Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

In the Spring group, our research has focused on the development of novel two-component peptide stapling methodologies and their application to biologically relevant targets (including MDM2/p53, CK2, BH3-proteins, ... TNKS). A few representative examples

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

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23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

full information on this image ». P53/43/545 (1931). Camp at foot of glacier.

11 Jun 2018: Absence of p53 in cells makes them more likely to become tumorous as damage can no longer be corrected. ... The team found that by decreasing activity of p53 in a cell, they could more efficiently edit healthy cells.

full information on this image ». P53/43/545 (1931). Camp at foot of glacier.

29 Jun 2024: Chiba Ene (PhD Medical Sciences) - Histone demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Activity through Lysine Demethylation.

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead