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Membrane fusion is the process whereby two separate lipid ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf16 May 2008: derived from a retrovirus. Syncytins function in cell–cell fusion during trophoblast formation. Immunoglobulin (Ig)-like -
doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: levels, is that overexpression of exogenous Tsg101 se-. questers endogenous Tsg101 binding partners (Vps28. ... Tal, a Tsg101-spe-. cific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus. -
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and Results that match 1 of 2 words
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The Rockefeller University Press, 0021-9525/97/02/567/15 $2.00The…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/8_Lingappa_JE_JCB_1997.pdf3 Feb 1997: . The Rockefeller University Press, 0021-9525/97/02/567/15 $2.00The Journal of Cell Biology, Volume 136, Number 3, February 10, 1997 567–581 567. A Multistep, ATP-dependent Pathway for Assembly ofHuman Immunodeficiency Virus Capsids in a -
«AltRefNo»
https://archives.chu.cam.ac.uk/wp-content/uploads/sites/2/2021/12/MSTN-catalogue.pdf15 Mar 2017: C. Milstein NCUACS 146/3/06. Catalogue of the papers and correspondence of. César Milstein, CH, FRS (1927-2002). By Heather Bird and Timothy E. Powell. C. Milstein. NCUACS catalogue no.146/3/06 Title: Catalogue of the papers and correspondence of -
© 2005 Nature Publishing Group Endophilin and CtBP/BARS are ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndopohilinNature2005.pdf4 Jan 2006: A JC201 strain ofEscherichia coli lacking endogenous LPAAT activity grows at 30 8Cbut not at 42 8C (ref. ... coli that has no endogenous LPAATactivity (JC201 strain) cannot growat 42 8C (sector 1). -
Volume 22 May 15, 2011 1625 Cytosolic aggregates perturb ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/69_Chakrabarti_O_MBC_2011.pdf11 Nov 2011: stable cell lines expressing either wild-type PrP or osteopontin (Opn)-PrP at levels comparable to endogenous PrP in brain (Kang et al., 2006). -
Vol. 9 (2012), Number 1 | Jg. 9 (2012), ...
https://www.robinson.cam.ac.uk/postkeynesian/downloads/Pusch/TP131112.pdf9 May 2012: Hansen, New York: W.W. Norton, 135 – 155. Setterfield, M. (2006): Effective demand and endogenous money in a path-dependent economy: Towards a ›Moorian‹ credit supply curve – and a reconciliation between ... ed.), Complexity, Endogenous Money and -
University of Cambridge Research Horizons Issue 9
https://www.cam.ac.uk/system/files/issue_9_research_horizons.pdf22 May 2009: Charles Darwin -
Tumour prevention by a single antibody domaintargeting the…
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17568777.pdf22 Jul 2007: cells infected with retrovirus only. Expression of intrabody. causes a morphological change in HT-1080 with reorganised. ... mice. All mice subcutaneously injected with EJ cells infected. with retrovirus only or retrovirus expressing the mutant. -
TTC5 mediates autoregulation of tubulin via mRNA degradation
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2019.pdf19 Nov 2019: Cite as: Z. Lin et al., Science 10.1126/science.aaz4352 (2019). REPORTS. First release: 14 November 2019 www.sciencemag.org (Page numbers not final at time of first release) 1. Alpha and beta tubulins form obligate heterodimers (hereaf-ter -
Transmembrane Domain Modulates Sorting of MembraneProteins in…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/29_Karsten_V_JBC_2004.pdf2 Jun 2004: 1B).BAPGRA4 was localized to dense granules as evidenced bycolocalization with the endogenous dense granule proteinGRA3 (32). ... Both endogenous GRA4 andBAPGRA4 were efficiently translocated across the ER mem-brane (Fig. -
tra_578 1..18
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Burtey%20IVF%20Traffic%2007.pdf15 May 2007: colocalizing with endogenous AP-2 complexes (Figure 2. G–J). In contrast, the IVA mutation resulted in complete. ... plasma membrane (Figure 5A), which colocalized with both. clathrin–DsRed and endogenous AP-2 complexes (Figure 5. -
This document captures the working notes from the workshop ...
https://www.cdbb.cam.ac.uk/files/scoping_workshop_complex_integrated_systems_april_2018_190627.pdf27 Jun 2019: Cambridge. - Operationalisation of CIS. - Context/population endogenous. dynamics needed. - Theoretical developments e.g. ... dynamics, co-evolution, failure of CIS. itself. - ITRC/Mistral/DAFNI- Methods to understand endogenous. -
The structure of human thyroglobulin
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TG_Nature2020.pdf31 Jan 2020: rTG appears to be indistinguishable by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) and cryo-electron microscopy (cryo-EM) from endogenous TG (eTG) puri-fied from thyroid glands of patients -
The structural basis of novel endosome anchoringactivity of KIF16B ...
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/17641687.pdf23 Jul 2007: performed dual immunofluorescence staining of expressed. KIF16B-PX and endogenous EEA1 using fixed HEK293 cells. ... In agreement with A431 cell localization, KIF16B-PX was. colocalized with endogenous EEA1 (Figure 6A). -
The price of free education: Extracting the school quality ...
https://www.christs.cam.ac.uk/sites/default/files/2018-09/Economics-dissertation.pdf25 Sep 2018: 2) No endogenous changes in group composition. Endogenous changes in group composition in difference-in-difference analyses using a repeated cross-section can often bias results. ... This means there isno change in group composition at all, endogenous or -
The patterned assembly and stepwise Vps4-mediated disassembly of…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Hurtig%202023%20sciadv.ade5224.pdf16 Jul 2023: 1A), hereafter calledVps4E209Q. This point mutation prevents AAA-ATPases like Vps4from hydrolyzing bound ATP and can therefore interfere with theactivity of endogenous Vps4 complexes when overexpressed (24,28). -
The mechanisms of integral membrane protein biogenesis
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/NRMCB_2021.pdf22 Sep 2021: Nature Reviews Molecular Cell Biology, doi:10.1038/s41580-021-00413-2 -
THE JOURNAL OF BIOLOGICAL CHEMWXXY Vol. 265, No. 34, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/2_Pewitt_EB_JBC_1990b.pdf29 Dec 2004: currently assessing the role of endogenous duck erythrocyte phosphatases in regulating the cotransporter. -
The Jour nal o f Cel l Bio logy ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/epsinR.pdf9 Jan 2003: Figure 6. Subcellular localization of epsinR. As a convention throughout the figure, myc-epsinR and mutants are labeled green and the endogenous proteins are labeled red. ... 3), and homologues are found in bothC. elegans and Drosophila. Thus, we used -
The Jour nal o f Cel l Bio logy ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/24_Fons_RD_JCB_2003.pdf6 Feb 2003: The. Jour. nal o. f Cel. l Bio. logy. JCB. Article. The Journal of Cell Biology, Volume 160, Number 4, February 17, 2003 529–539http://www.jcb.org/cgi/doi/10.1083/jcb.200210095 529. Substrate-specific function of the translocon-associated protein -
The inherent instability of the macroeconomy and the fiscal rules: a …
https://www.robinson.cam.ac.uk/postkeynesian/downloads/Dafermos/YD200514S.pdf19 May 2014: Minsky (1975, 1982, 1986) developed a theory that explains how indebtedness can increase in periods of tranquillity as a result of endogenous forces that reduce the desired margins of safety ... A principal outcome of the analysis was that the -
The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Lundmark_McMahon_GRAF2008.pdf28 Nov 2008: G) Epifluorescence micrographs of a HeLa cell incubated with CTxB for 5 min before fixation and staining for endogenous GRAF1. ... B, Confocal micrograph of an NIH 3T3 cell stained for endogenous GRAF1 distribution. -
The ER membrane protein complex promotes biogenesis of sterol-related …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/JCS_2019.pdf18 Jan 2019: SQS insertion by EMC enables sterol biosynthesisTo determine the mechanism responsible for downregulating SQSin EMC-knockout cells, we monitored endogenous SQS synthesisand turnover by performing 35S-Met/Cys pulse-chase assays. ... A) 35S-Met/Cys -
The ER membrane protein complex is a transmembrane domain insertase
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017c.pdf27 Jan 2018: This system contains endogenous mRNAs (primarily encoding the 14 kD globins and a prominent 70 kD protein) that contribute to background, but has the advantage of retaining native cytosolic conditions, most ... aureus is used to digest endogenous mRNA. -
The EMBO Journal Vol.17 No.18 pp.5273–5285, 1998 Crystal structure ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1998.pdf9 Sep 1998: We believe this effectis due to sequestration of endogenous dynamin away fromclathrin-coated pits. -
The Eagle 2023 THE EAGLE 2023 1 The Eagle ...
https://johnian.joh.cam.ac.uk/wp-content/uploads/2023/09/The-Eagle-2023_Web-version.pdf1 Sep 2023: The Eagle 2023. THE EAGLE 2023 1. The Eagle 2023VOLUME 105. WELCOME. 2. Published in the United Kingdom in 2023 by St John’s College, CambridgeFirst published in the United Kingdom in 1858 by St John’s College, Cambridge. Cover photo by: Rich -
The Biogenesis of Multipass Membrane Proteins
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/CSHL_Persp_2022.pdf13 Sep 2022: The Biogenesis of Multipass Membrane Proteins. Luka Smalinskait _e and Ramanujan S. Hegde. MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom. Correspondence: rhegde@mrc-lmb.cam.ac.uk. Multipass membrane proteins contain two or -
The Age of Revolution i789-1848 E R I C ...
https://www.clarehall.cam.ac.uk/wp-content/uploads/2023/01/Hobsbawm-The-Age-of...-Revolution-Capital-Empire-selection.pdf27 Jan 2023: The Age of Revolution. i789-1848. E R I C HOBSBAWM. V I N T A G E B O O K S. A Division of R a n d o m H o u s e , Inc. New York. FIRST VINTAGE BOOKS EDITION, AUGUST 1996. Copyright 1962 by E. J. Hobsbawm. All rights reserved under International and -
The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersinia …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Papers/Mittal_JBC2010.pdf4 Oct 2010: remove endogenous AcCoA) and used in acetyltransferaseassays.Size-exclusion Chromatography of HeLa Cytosol—The re-. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/EMreview.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/mcmahon.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
SVUS002-16.tex
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/31_Rane_Chapter_2005.pdf21 Sep 2006: As predicted, these mice are resis-tant to prion infection and propogation41,42, consistent with a require-ment for endogenous PrPC in the replication of PrPSc. -
sv-lncs
https://www.robinson.cam.ac.uk/postkeynesian/downloads/Werner/RW301012.pdf31 Jul 2012: Towards a New Research Programme on ‘Banking and the Economy’ –. Implications of the Quantity Theory of Credit for the Prevention and Resolution of Banking and Debt Crises. Abstract. The financial crisis has triggered a new consensus among -
supplementary figures 070814 JL
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/scc32014si.pdf8 Aug 2014: microscopy (Fig 4A). (B) Cells with endogenous Scc1 or Scc3 (K20783) C-terminal. ... at the indicated time points and compared to levels made by endogenous tagged. -
Supplementary Figure 1Lysophosphatidic acid acyl transferase (LPAAT)…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndoSupFigs.pdf4 Jan 2006: various endophilins and controls. a. b. c. Transformation of JC201 bacteria with endophilin does not lead to an acceleration of growth kinetics, unlike transformation of the endogenous LPAAT. -
Supplemental Materials Supp MethodsSupp Fig. 1 Sequence conservation…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004Sup.pdf23 Nov 2004: In the supplementary material of the previous paper we showed that these puncta co-localisedwith endogenous endocytic components such as eps15 and dynamin. -
Sraffa-Keynes 3-2 (March 2012)
https://www.robinson.cam.ac.uk/postkeynesian/downloads/Park/MSP130312v2.pdf7 Mar 2012: 1. Sraffa’s ‘Given’ Quantities of Output and Keynes’s Principle of Effective Demand. Man-Seop Park. Korea University manseop@korea.ac.kr. [I]t is in the ‘present’ that the ‘normal’ rate of profits has always been firmly located. … -
SISTEMA NACIONAL DE INOVAÇÕES, COMPETITIVIDADE E CRESCIMENTO DAS…
https://www.robinson.cam.ac.uk/postkeynesian/downloads/Resende/MR070513.pdf4 Mar 2013: considered as a determinant of savings. It is endogenous and passively adjusts to produce. -
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor…
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/COVID%20vaccine%202021%201873-3468.14171.pdf29 Aug 2021: Iba1) or 60 min at 37 C (anti-CD3, anti-CD4). This wasfollowed by blocking of endogenous peroxidase (peroxidase. -
Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and…
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/2015-4.pdf30 Jun 2015: Under these conditions, we only observed endogenous acetylcholine EPSCs. To recordGABAergic postsynaptic currents, the holding potential was 0 mV, at which we only observemIPSCs. ... Supporting InformationS1 Fig. Stimulus-evoked EPSCs and endogenous -
Science Journals — AAAS
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/wp-content/uploads/sites/8/2023/08/Science_2021.pdf26 Aug 2021: Othersubunits of the 19S base were copurified atlower levels, consistent with partial assemblyof PSMC5 with endogenous base subunits pres-ent inthe lysate (table S5). ... Boosting HERC1 levelsusing CRISPR activation (31) of the endoge-nous HERC1 promoter -
RUSTAT CONFERENCE- CyberFinance-Report
https://www.jesus.cam.ac.uk/sites/default/files/inline/files/Rustat%20Conference%20Cyber%20Finance_0_0.pdf10 May 2016: The approach of the research Dr Clack pursues at UCL adopts neither of the aforementioned approaches but focuses on endogenous feedback loops. -
Ribosome-associated protein quality control
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/98_Brandman_O_NSMB_2016.pdf18 Feb 2016: Ribosome profiling in the presence and absence of Dom34 has shown that an endogenous substrate for this pathway is Hac1, a cytosolically spliced mRNA whose incorrect ligation results in an mRNA ... The key open questions include the following: (i) What -
REPORT◥ PROTEOSTASIS UBE2O is a quality control factor fororphans ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017b.pdf4 Aug 2017: Catalytically inactive UBE2O(C1040S) alsorecovered endogenous and exogenous RPL24(but no detectable ubiquitinated forms), whereasUBE2O(DCR2) interacted poorly with RPL24 (fig.S10D). ... The heterogeneity of ubiquitin bands in the samples with cytosol is -
REPORT◥ PROTEIN HOMEOSTASIS Mechanistic basis for a moleculartriage…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/Science_2017.pdf19 Jan 2017: endogenous proteins with recombinant variantsrevealed the functional roles for all of the factorsand interactions. ... C) Immunoblots (IB) for triage components of control or BAG6 complex-depleted RRL replenished with recombinant BAG6 sub-complexes used -
Qrb1300006 1..40
https://www2.mrc-lmb.cam.ac.uk/groups/nu/pdf/qrb13.pdf30 Jul 2013: inherent flexibility of the tubes and other factors, such as heterogeneity of the endogenous. -
Protein targeting and degradation are coupled for elimination of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/73_Hessa_T_Nature_2011.pdf14 Jul 2011: endogenous ubiqui-tin was more than 90% competed out, resulting in few or no untagged ubiquiti-nated products. ... The absence of endogenous charged tRNAs and haemoglobinincreased photocrosslinker incorporation and photolysis, respectively. -
Protection from cytosolic prion protein toxicityby modulation of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/30_Rane_N_EMBO_2004.pdf8 Nov 2004: Endogenous NF-kB (indicated by an aster-isk) serves as a loading control. ... Immunoblots were probed with antibodiesagainst PrP, GFP, and an endogenous protein, the beta subunit ofSec61.
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