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doi:10.1016/j.cell.2006.01.047
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/16615893.pdf18 Apr 2006: levels, is that overexpression of exogenous Tsg101 se-. questers endogenous Tsg101 binding partners (Vps28. ... Tal, a Tsg101-spe-. cific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus. -
Membrane fusion is the process whereby two separate lipid ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/MartensMcMahon2008.pdf16 May 2008: derived from a retrovirus. Syncytins function in cell–cell fusion during trophoblast formation. Immunoglobulin (Ig)-like -
Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of …
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/CircGen_2019.pdf1 Dec 2019: Circ Genom Precis Med. 2019;12:e002507. DOI: 10.1161/CIRCGEN.119.002507 September 2019 397. BACKGROUND: Pediatric cardiomyopathies are a clinically and genetically heterogeneous group of heart muscle disorders associated with high morbidity and Results that match 1 of 2 words
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The Rockefeller University Press, 0021-9525/97/02/567/15 $2.00The…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/8_Lingappa_JE_JCB_1997.pdf3 Feb 1997: . The Rockefeller University Press, 0021-9525/97/02/567/15 $2.00The Journal of Cell Biology, Volume 136, Number 3, February 10, 1997 567–581 567. A Multistep, ATP-dependent Pathway for Assembly ofHuman Immunodeficiency Virus Capsids in a -
Molecular Biology of the CellVol. 8, 2003–2015, October 1997 ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/WiggeKohler_McMahon1997.pdf10 Oct 1997: We interpret these results tomean that either Amph1 or Amph2 overexpressionalone leads to sequestration of endogenous dynamininto inactive complexes, but when the two proteins areexpressed together, forming a heterodimer, endocyto-sis -
Journal of Lipid Research Volume 39, 1998 1287 Translocational ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/10_Rusinol_AE_JLR_1998.pdf30 May 1998: m. EDTA (pH 7.4) for 30 min at0. 8. C, then with micrococcal nuclease to reduce background trans-lation products due to endogenous mRNA (29). -
The EMBO Journal Vol.17 No.18 pp.5273–5285, 1998 Crystal structure ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Owen_McMahon1998.pdf9 Sep 1998: We believe this effectis due to sequestration of endogenous dynamin away fromclathrin-coated pits. -
cm6307.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/TAXOL.C&B.pdf18 Feb 1999: Such molecules mightmimic an endogenous cellular factor, presumably a lesspotent one, that helps to stabilise microtubules in normalcytoplasm; the natural reagent might be a small molecule orpart of a microtubule-associated -
articles Nucleotide-dependent conformational changes in dynamin:…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Stowell_McMahon1999.pdf30 Apr 1999: and endogenous rat brain vesicles. J. Biol. Chem. 268, 17240–17246 (1993). -
d402_16g 822..826
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/15_Hegde_RS_Nature_1999.pdf9 Dec 1999: Trans-genic (Tg) mice expressing each of these mutant PrPs in the FVB/Pmp0/0 background (null for the endogenous PrP gene) weregenerated and characterized (see Table 1 and Fig. -
pq240013132p
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/16_Wilhelm_JE_PNAS_2000.pdf10 Nov 2000: 1B), despitethe fact that endogenous Vg1 was expressed only in the late-stageoocytes (Fig. ... 1C). This result raisesthe possibility that the endogenous, localized Vg1 message is inan environment that is free from repression. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/EMreview.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
TBS may template.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/epsin/EM/mcmahon.pdf3 May 2002: This might be caused bycompetition for clathrin binding between the injectedpeptide and the endogenous protein, therebypreventing endogenous AP180 and AP2 frompromoting clathrin assembly at the plasmamembrane. -
LectList2002
https://www.reporter.admin.cam.ac.uk/reporter/2002-03/special/01/p170-179.pdf23 Sep 2002: Endogenous stem cell responses toinjury in the CNS. DR S. CHARNOCK-JONESTu. -
The Jour nal o f Cel l Bio logy ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/epsinR.pdf9 Jan 2003: Figure 6. Subcellular localization of epsinR. As a convention throughout the figure, myc-epsinR and mutants are labeled green and the endogenous proteins are labeled red. ... 3), and homologues are found in bothC. elegans and Drosophila. Thus, we used -
The Jour nal o f Cel l Bio logy ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/24_Fons_RD_JCB_2003.pdf6 Feb 2003: The. Jour. nal o. f Cel. l Bio. logy. JCB. Article. The Journal of Cell Biology, Volume 160, Number 4, February 17, 2003 529–539http://www.jcb.org/cgi/doi/10.1083/jcb.200210095 529. Substrate-specific function of the translocon-associated protein -
Bb9e55.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Vallis_McMahon1999.pdf21 Mar 2003: Mol Biol Cell 1998, 9:195a. 22. Tuma PL, Stachniak MC, Collins CA: Activation of dynamin GTPaseby acidic phospholipids and endogenous rat brain vesicles. ... such adynaminPH construct into COS cells will be even betterat sequestering endogenous dynamin -
554 Research Paper Inhibition of receptor-mediated endocytosis by the …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/wigge_McMahon1997.pdf21 Mar 2003: The most likely explanation for this is that theinteraction of dynamin with endogenous amphiphysin wasdisrupted in these cells. ... J Cell Biol 1993, 127:725-735. 18. Tuma PL, Stachniak MC, Collins CA: Activation of dynamin GTPaseby acidic phospholipids -
554 Research Paper Inhibition of receptor-mediated endocytosis by the …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/wigge_McMahon1997.pdf?cmd=Retrieve&db=PubMed&list_uids=9348539&dopt=Abstract21 Mar 2003: The most likely explanation for this is that theinteraction of dynamin with endogenous amphiphysin wasdisrupted in these cells. ... J Cell Biol 1993, 127:725-735. 18. Tuma PL, Stachniak MC, Collins CA: Activation of dynamin GTPaseby acidic phospholipids -
3747_0_supp_7_1052456676
https://www2.mrc-lmb.cam.ac.uk/groups/wschafer/christian.pdf9 May 2003: endogenous proteins and quenching of signals by other cellular proteins. This discussion. -
Lecture List 2003 - Medical and Veterinary Science Tripos
https://www.reporter.admin.cam.ac.uk/reporter/2003-04/special/01/pdfs/165.pdf24 Sep 2003: M. 9 Feb. Endogenous stem cell responses toinjury in the CNS. -
Membrane curvature sensing and induction: The function of BAR domains …
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/BARdomains/BARsupp.pdf20 Nov 2003: S6. Colocalization of wild type, mutant, and endogenous arfaptin with TGN46 Table S1. -
doi:10.1016/j.ceb.2003.11.005
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/cocb%202003.pdf27 Nov 2003: Immunofluorescence microscopy of endogenous Mbl in fixed cells gave. similar images. -
JOURNAL OF VIROLOGY, Feb. 2004, p. 2088–2099 Vol. 78, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/27_Tremblay_P_JV_2004.pdf15 Jan 2004: Prnp0/0, except for Tg(MoPrP)4053/Prnp/, in which the endogenous Prnp genewas maintained by breeding with FVB mice (Charles River Laboratories, Hol-lister, Calif.). -
JCB Article The Journal of Cell Biology, Volume 164, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/28_Snapp_EL_JCB_2004.pdf15 Apr 2004: These conclu-sions suggested that, in principle, the organization of multi-protein complexes could be assessed with antibody probes.Thus, if endogenous translocon components could be labeledwith dye-conjugated antibodies while -
Transmembrane Domain Modulates Sorting of MembraneProteins in…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/29_Karsten_V_JBC_2004.pdf2 Jun 2004: 1B).BAPGRA4 was localized to dense granules as evidenced bycolocalization with the endogenous dense granule proteinGRA3 (32). ... Both endogenous GRA4 andBAPGRA4 were efficiently translocated across the ER mem-brane (Fig. -
doi:10.1016/j.molcel.2004.08.030
https://www2.mrc-lmb.cam.ac.uk/groups/JYL/PDF/Haering%20Mol%20Cell%202004.pdf20 Sep 2004: Cells separatedsister chromatids with identical kinetics to those thatof the GAL1-10 promoter in cells with an endogenous. ... Nevertheless, noncleavableScc1-HA3 from the endogenous SCC1 promoter. The. sole copy of Cdc20 in all three strains was -
LectList2004 - 75962
https://www.reporter.admin.cam.ac.uk/reporter/2004-05/special/01/pdfs/med_vet_2.pdf22 Sep 2004: 14 Feb. Endogenous stem cell responses to. injury in the CNS. -
doi:10.1016/j.cub.2004.07.058
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15296756.pdf6 Oct 2004: The challenge now is to establish the molecularhave similar phenotypes: they retain a similar shape tolinks between endogenous ARAP3’s control of Rho andcontrol cells, but on PDGF stimulation their lamellipodiaArf -
doi:10.1016/j.devcel.2004.09.003
https://www2.mrc-lmb.cam.ac.uk/groups/rlw/download/publications/15469844.pdf1 Nov 2004: InhVps37A and hVps37B (Bache et al., 2004; Stuchell et al.,addition, they play a critical role in retrovirus budding.2004), while the human ESCRT-II subunits correspondStructural understanding of ESCRT interaction ... The CCP4 suite: Morita, E., and -
Protection from cytosolic prion protein toxicityby modulation of…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/30_Rane_N_EMBO_2004.pdf8 Nov 2004: Endogenous NF-kB (indicated by an aster-isk) serves as a loading control. ... Immunoblots were probed with antibodiesagainst PrP, GFP, and an endogenous protein, the beta subunit ofSec61. -
doi:10.1016/j.cub.2004.09.077
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Snx1PeteCullen2004/Snx1PeteCullen2004.pdf23 Nov 2004: Endogenous SNX1 was enriched on tubularmembranes in close vicinity to endosomal vacuoles (Fig-ure 3). ... These data establish a role for endogenous SNX1in the retrieval of the CI-MPR from early endosomes tothe TGN. -
Evolving nature of the AP2 a-appendage hubduring clathrin-coated…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004.pdf23 Nov 2004: The puncta. begin to appear at temperatures below 181C and colocalisewith endogenous AP2. ... 6C. 6C. 37C. Endogenous AP2Overexpressed epsins Transferrin uptakeA. B. C (d) Coated vesicle assemblyClathrin. -
Supplemental Materials Supp MethodsSupp Fig. 1 Sequence conservation…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/AP2Hub_EMBO2004/AP2Praefcke2004Sup.pdf23 Nov 2004: In the supplementary material of the previous paper we showed that these puncta co-localisedwith endogenous endocytic components such as eps15 and dynamin. -
53091 361..366
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahonE.pdf3 Dec 2004: endogenous AP2 (middle, AP6 antibody) and transferrin uptake (right). A strong. -
53091 361..366
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/McMahon01020.pdf3 Dec 2004: endogenous AP2 (middle, AP6 antibody) and transferrin uptake (right). A strong. -
Mechanisms of Dense Core Vesicle Recapture following “Kiss andRun” ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Insulin_Tsuboi_JBC2004/Insulin_TsuboiJBC2004.pdf6 Dec 2004: K535A), or amphiphysin-1, all likely tobind to key interacting partners of endogenous dynamin, mightchange the diameter of the fusion pore and thus change thekinetics of tPA or NPY release. -
Molecular Biology of the CellVol. 16, 279 –291, January ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/32_Levine_CG_MBC_2005.pdf21 Dec 2004: A digitonin extract containing cytosolic proteins in-cluded the majority of endogenous NF-B (Figure 3B) aswell as several other cytosolic markers such as heat shockprotein (HSP)70 and HSP90 (our ... ng of plasmid (lane 1) was compared with endogenous -
THE JOURNAL OF BIOLOGICAL CHEMWXXY Vol. 265, No. 34, ...
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/2_Pewitt_EB_JBC_1990b.pdf29 Dec 2004: currently assessing the role of endogenous duck erythrocyte phosphatases in regulating the cotransporter. -
PII: S1534-5807(04)00100-5
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/Johannes_DevCell2004.pdf22 Mar 2005: Bar 10 m. endogenous MPR300 and TGN46 were relocalized to these conditions was not addressed directly. ... In agreement with these observations, we foundthat the endogenous EGF receptor was not relocalizedmembranes. -
doi:10.1016/j.devcel.2005.09.001
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/37_Shaffer_KL_DevCell_2005.pdf7 Oct 2005: he same for both Crt and Prl-Crt and were comparableo the levels of endogenous Crt (Figure 5A). ... A) Crt/ cells stably expressing either Crt-GFP or Prl-Crt-GFPwere analyzed (in duplicate) by immunoblotting with anti-Crt andanti-Sec61β (an endogenous -
© 2005 Nature Publishing Group Endophilin and CtBP/BARS are ...
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndopohilinNature2005.pdf4 Jan 2006: A JC201 strain ofEscherichia coli lacking endogenous LPAAT activity grows at 30 8Cbut not at 42 8C (ref. ... coli that has no endogenous LPAATactivity (JC201 strain) cannot growat 42 8C (sector 1). -
Supplementary Figure 1Lysophosphatidic acid acyl transferase (LPAAT)…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/GallopEndoSupFigs.pdf4 Jan 2006: various endophilins and controls. a. b. c. Transformation of JC201 bacteria with endophilin does not lead to an acceleration of growth kinetics, unlike transformation of the endogenous LPAAT. -
IntroductionThe endosomal system functions as an internal…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SNX2Cullen2005.pdf17 Jan 2006: 5A,B). Furthermore,there was a clear enrichment of endogenous SNX2 on SNX1. ... Cells were then fixed and stained againstendogenous SNX1, endogenous SNX2 and endogenous mVps26. -
7400749.qxd
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/41_Ashok_A_EMBORep_2006.pdf19 Jun 2006: J Cell Biol 129: 1509–1522. Morita E, Sundquist WI (2004) Retrovirus budding. ... Keywords: prions; retrovirus budding; exosome; endosomal transport;lysosome; multivesicular bodySubmitted 24 May 2006; accepted 31 May 2006. -
plbi-04-09-03 1532..1548
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/SchmidBetaPaper/BetaHub.pdf31 Aug 2006: Role of the AP2 b-Appendage Hubin Recruiting Partners for Clathrin-CoatedVesicle AssemblyEva M. Schmid. 1[, Marijn G. J. Ford. 1[, Anne Burtey. 2, Gerrit J. K. Praefcke. 3, Sew-Yeu Peak-Chew. 1, Ian G. Mills. 4,. Alexandre Benmerah2. , Harvey T. -
Monitoring chaperone engagement of substratesin the endoplasmic…
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/39_Snapp_EL_PNAS_2006.pdf21 Sep 2006: We therefore stably expressed Crt-GFP in crt/ fibroblasts at alevel corresponding to endogenous Crt levels of matched crt/ cells(Fig. -
SVUS002-16.tex
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/31_Rane_Chapter_2005.pdf21 Sep 2006: As predicted, these mice are resis-tant to prion infection and propogation41,42, consistent with a require-ment for endogenous PrPC in the replication of PrPSc. -
Acetylation of MEK2 and I{kappa}B kinase (IKK) activation loop…
https://www2.mrc-lmb.cam.ac.uk/groups/hmm/publica/YopJ.pdf28 Nov 2006: 1d). Under our experimental conditions, endogenous levelsof MKK3 protein could not be detected by using the anti-MKK3antibody. ... This effect of expressed YopJ on endogenous MEK1/2was seen as early as 6 h after transfection of cells (data notshown). -
doi:10.1016/j.cell.2006.10.032
https://www2.mrc-lmb.cam.ac.uk/groups/hegde/download/43_Kang_SW_Cell_2006.pdf30 Nov 2006: Substrate-Specific TranslocationalAttenuation during ER Stress Definesa Pre-Emptive Quality Control PathwaySang-Wook Kang,1,4 Neena S. Rane,1,4 Soo Jung Kim,2 Jennifer L. Garrison,3 Jack Taunton,3. and Ramanujan S. Hegde1,1 Cell Biology and
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