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11 Jun 1997: Based on sequence similarity and structural studies,modular PH, EF-hand and C2 domains have beendescribed in many proteins.22-24 PLCδ1 PH domainshares a high degree of structural similarity with ... 24. Kawasaki H, Kretsinger R (1994) Calcium-binding

9 Jan 1998: Biochem. 24, 255–302 (1995). 22. Leslie, A. G. W. Recent changes to the MOSFLM package for processing film and image plate data (SERCLaboratory, Daresbury, Warrington, UK, 1991). ... 23. The CCP4 suite: Programs for protein crystallography. Acta

15 Jan 1998: 139 (E) 394 412 (Ta3) 2.64 (9)4 490 495 (Ta4) 5 6 205 222 (F) 525 534 (Ta5) 2.24 (5)60 536 545 (Ta50) 7 243 263 (G) ... 24%. Despite this relatively weak con-servation both enzymes share a very similar three-dimensional structure (Moser et al., 1997).

3 Feb 1998: B) The F2 transgenic animals (n 5 24) were observedfor signs of neurodegenerative disease, including ataxia and paresis. ... To. ensure that vesicle integrity was maintainedduring the proteolysis reaction, we alsoevaluated the accessibility to protease

30 May 1998: Nature. 365: 65–68. 24. Gordon, D. A., J. R. Wetterau, and R. ... J. Lipid Res. 24: 1243–1250. 33. Rouser, G., A. N. Siakatos, and S.

9 Sep 1998: 10.2 (24.1) 9.0 (17.9)Riso (%). c 32.5Phasing power 1.29 (0.77)Anomalous phasing power 1.33 (0.57)Resolution in outer shell (Å) ... 2.20 3.24–3.0Rfactor 0.190Rfree (10% of data) 0.258.

20 Apr 1999: All four calculationsproduced the same filament arrangement. After two cycles of unbendingand correction for the contrast transfer function, amplitudes and phasesfrom 24 images were merged. ... FtsZ sheet structure. and schematic plots of protein

30 Apr 1999: Results of in vitro experiments have revealed that dynamin isable to bind and tubulate lipid membranes in the absence of anyother accessory factors23,24. ... RECEIVED 24 FEBRUARY 1999; REVISED 12 MARCH 1999; ACCEPTED 12 MARCH 1999; PUBLISHED MAY 1999.

26 May 1999: J. Appl. Crystallogr. 24, 946 –950. Kull, F.J., Sablin, E.P., Lau, R., Fletterick, R.J., and Vale, R.D.

6 Jul 1999: Adaptors EM, rotary shadow and deep-etch; APcomplexes (13). ;25 (2D). Crystallography; AP2 m2 residues 158 to435 (24). ... 2.7 Phe174, Arg423 (24) YxxØ endocytosis signals. Crystallography; AP2 COOH-terminala-adaptin appendage domain residues701 to 938

6 Jul 1999: Adaptors EM, rotary shadow and deep-etch; APcomplexes (13). ;25 (2D). Crystallography; AP2 m2 residues 158 to435 (24). ... 2.7 Phe174, Arg423 (24) YxxØ endocytosis signals. Crystallography; AP2 COOH-terminala-adaptin appendage domain residues701 to 938

7 Jul 1999: Joint CCP4 and ESF-EACBM Newsletter for Protein Crystallography, 33, 22-24. Gabius, H. ... Biophys.Biomol. Struct. 24, 551-577. Sambrook, J., Fritsch, E. F. & Maniatis, T.

10 Sep 1999: 15, 430-434. 24. Akhmedov, A.T., Frei, C., Tsai-Pflugfelder, M., Kemper, B., Gasser,S.M. & ... J. Appl. Crystallogr.24, 946-950. 33. Barton, G.J. (1993). ALSCRIPT: a tool to format multiple sequencealignments.

11 Nov 1999: response to oxidative stress. Mol. Carcin. 24, 1524 (1999). 14. Yin, Y. ... UK, 1992). 24. CCP4. Collaborative Computing Project 4: A suite of programs for protein crystallography.

9 Dec 1999: TgSHaPrP(DSTE)H F1788 6 4 24 323 6 14 (9/9)TgSHaPrP(A117V)L E15781 31 0.4 12 70 6 2 (6/6)TgSHaPrP(A117V)H E15727 31 4 ... IIH F1198 48 4 192 58 6 11 (24/24)# NDI. Values were derived from quantication of Fig.

13 Sep 2000: Cell Struct. Funct. 24,285 – 290. Lu, C.L., Stricker, J., and Erickson, H.P. ... EMBO J. 16, 5455 –5463. Received May 24, 2000; accepted July 14, 2000.

4 Oct 2000: E#N# 04412 (B<-! A # # " 3 16G7H#. # >$$I# ># 3 J#3# 04492 ' ( ' ) % % # ) &. 2'99G997#. $# B # O (# 0442 ( (- $ $ 6H $ # # / 0/ 24 64HG647#. (#-#

10 Nov 2000: 24. prolactin coding region of Prl (excised with NcoI and BlpI) witha PCR product encoding full-length b-lactamase (b-lac). ... 24). They were used within 5 days of harvest.Oocytes were staged according to published criteria, and tran-scripts were

1 Dec 2000: Crystal 1 50–3.2 146,371/23,318 100 (100) 0.11 21.8 (3.6)Crystal 23 50–3.0 270,093/24,791 82.4 (51.3) ... Merge 50–3.0 7405 6 24,273 1510 0.21 0.28 (5.4) 0.0093 Å 1.298 22.78.

20 Feb 2001: J. Appl. Crystallog. 24, 946-950. Laskowski, R. A., Macarthur, M. W., Moss, D.

5 Mar 2001: 1990) Annu.Rev. Genet. 24, 249274. [3] Lutkenhaus, J. and Addinall, S.G. ... Appl. Crystallogr. 24, 946950.[34] Merritt, E.A. and Bacon, D.J. (1997) in : Macromolecular Crys-.

6 Mar 2001: 24. Vallis, Y., Wigge, P., Marks, B., Evans, P. R. & McMahon, H.

4 May 2001: SeMet-substituted crystals were grown in thesame manner as for the native protein but with 24% PEG 2000, 0.1 Msodium citrate pH 4.8, 3.6% ethanol for the crystallization ... J. Appl. Crystallogr., 24,946950. Laskowski,R.A., Macarthur,M.W., Moss,D.S. and

22 Jun 2001: Consistent withprevious studies (4, 10) when only 24 mature amino acids (maa)beyond the signal sequence have been synthesized, pPrl has not. ... Zheng, T. & Nicchitta, C. V. (1999) J. Biol. Chem. 274, 36623–36630.24.

26 Jun 2001: Second, mutations disrupting theh-region often severely impair the obligate targeting function ofa signal sequence (24).

30 Aug 2001: 51.1 Å. IA. IBIIB. IIA. F-actin MreB. 55 Å. 1. 24. ... Interestingly, the rened model ofF-actin23,24 is less similar to our crystal structure than the initialunrened model, in which the crystal structure of G-actin incomplex with DNase I was

3 Nov 2001: 24,pp. 255-302, Plenum Press, New York. 26. Wolf, S. G., Nogales, E., Kikkawa, M., Gratzinger,D., Hirokawa, N. & ... S. (1968). RelativisticHartree-Fock X-ray and electron scattering factors.Acta Crystallog. sect. A, 24, 390-397.

9 Nov 2001: Amphiphysin is necessaryfor organization of the excitation–contraction coupling machineryof muscles, but not for synaptic vesicleendocytosis in DrosophilaAzam Razzaq,1,2 Iain M. Robinson,1 Harvey T. McMahon,3 Jeremy N. Skepper,4 Ya Su,1,7. Andrew C

12 Nov 2001: Mol Microbiol 1996, 22:231-237. 19. Margolin W: Themes and variations in prokaryotic cell division.FEMS Microbiol Rev 2000, 24:531-548. ... J Cell Biol 2000, 151:F19-F21.See annotation to [24•]. 24. Kiessling J, Kruse S, Rensing SA, Harter K, Decker EL,

14 Jan 2002: 24.Chook, Y.M., Gray, J.V., Ke, H. & Lipscomp, W.N. The monofunctional chorismate mutase from Bacillus subtilis: structure determination of chorismate mutase and its complexes with a transition state ... J. Appl. Cryst. 24, 946-950 (1991). 39.Merrit, E.A.

24 Jan 2002: Tranfected. strate to a degradative pathway. Precedence exists for cells were analyzed between 24 and 60 hr after transfection.

19 Apr 2002: Molecular Cell, Vol. 9, 773–788, April, 2002, Copyright  2002 by Cell Press. Molecular Architecture of SMC Proteinsand the Yeast Cohesin Complex. other eukaryotes so far studied and several have alsobeen implicated in sister chromatid cohesion

20 Apr 2002: An initial model wasbuilt using the program O (24). Noncrystallographic symmetryrestrained positional and temperature factor refinement werecarried out with the program X-PLOR. ... S. (1993) Acta Crystallogr. D 49,. 129 –147.24. Jones, T. A., Zou, J.-Y.

20 Apr 2002: Crystal Structure of a Calcium-Phospholipid Binding Domainfrom Cytosolic Phospholipase A2. (Received for publication, September 24, 1997). ... 1991) J. Appl. Crystallogr. 24, 946 –95072. Nicholls, A. (1992) GRASP: Graphical Representation and Analysis

20 Apr 2002: diC7PC (8 mM) no significant activation observed 0.85( 0.06 24.7( 2.9(1.7( 0.2). ... 132) PI-PLCδ1 and at 24-45 C for full-length PI-PLCδ1 (Figure 7A,B).

20 Apr 2002: PLC Activity in Mixed Micelles—The assay of hydrolysis of PIP2 andPI was based on methods described previously (19, 21, 24, 25). ... Thecalcium dependence of PIP2, PIP, and PI hydrolysis was analyzed usinga range of calcium buffers as described

20 Apr 2002: THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 273, No. 30, Issue of July 24, pp.

20 Apr 2002: Deletion variants of PLC-N1 and PLC-Qlacking this second lobe are inactive, probably dueto destabilising the fold of the enzyme [23,24].Although sequence similarity throughout the EF-. ... Bio-phys. Res. Commun. 211 (1995) 364369. [24] Y. Emori, Y. Homma,

20 Apr 2002: baculovirus expression of Src family kinases were madeby subcloning the cDNAs (24) encoding activated Src (Y527F Src),activated Fyn (Y531F Fyn), and activated Lck (Y525F Lck) into thebaculovirus transfer vector ... Some of the additional sites couldbe

20 Apr 2002: 24). Thetopology of the domain is identical to that of phospholipase Cd1and the recently reported calcium-independent C2 domainfrom protein kinase Cd (23), whereas it is a circular permuta-tion of ... 24. Sutton, R. B., and Sprang, S. R. (1998) Structure

20 Apr 2002: Negatively charged regions are shown in red and positively chargedin blue (ranging from 18 kT/e to 24 kT/e). ... Crystallogr.heavy-atom parameter refinement for multiple isomorphous re- 24, 946–950.placement and multiwavelength anomalous diffraction

20 Apr 2002: 4.6)〈I/σ(I)〉b 24.1(5.1) 15.7(4.3) 20.6(4.4) 17.2(4.9).

20 Apr 2002: 1996)J.Biochem. 120, 671-676. Kraulis, P. J. (1991)J. Appl. Crystallogr. 24, 946-950.Lee, S.

20 Apr 2002: Molecular Cell, Vol. 6, 909–919, October, 2000, Copyright 2000 by Cell Press. Structural Determinants of Phosphoinositide3-Kinase Inhibition by Wortmannin, LY294002,Quercetin, Myricetin, and Staurosporine. for proteins such as protein kinase B

29 Apr 2002: an electron-dense core (24).The use of lipophilic FM dyes to follow vesicle cycling has alsosuggested the existence of fast kiss-and-run exocytosis in syn-aptosomes (25) and in ... timedetermined. For control cells, the data are derived from 12 cells and

3 May 2002: In each of thesecases, purified soluble factors and syntheticliposomes are sufficient to reconstitute coatformation [21–24]. ... Proc. Natl. Acad. Sci. U. S. A. 95,11199–11204. 24 Matsuoka, K.

3 May 2002: In each of thesecases, purified soluble factors and syntheticliposomes are sufficient to reconstitute coatformation [21–24]. ... Proc. Natl. Acad. Sci. U. S. A. 95,11199–11204. 24 Matsuoka, K.

5 Jul 2002: Cell 1986;47:711– 719. 24. Liao S, Lin J, Do H, Johnson AE. ... Molec Biol Cell 1998;9:2681– 2697. Problems and paradigms. BioEssays 24.8 747.

30 Jul 2002: age but lost its platform subdomain. The high degree of observation that there is a pool of epsin located at theGolgi [24]. ... 1996). Methods used in271, 12111–12116.the structure determination of bovine mitochondrial F1 ATPase.24.

12 Oct 2002: Resolution (AÊ ) 2.0 2.0Observations/unique reections 83 922/24 307 84 280/24 356Completeness (last shell) % 93.6 (74.1) 93.7 (74.1)Rmerge. ... The supernatant was collected anddialysed against 50 mM TrisHCl pH 8.0 and 1.5 M urea for 16 h, andthen