Search

23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

21 Jul 2023: Cancer is a disease of mutation, and the most commonly mutated protein by far is the tumour suppressor p53. ... Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53..

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge.

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge.

23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.

23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge.

21 Jul 2023: Tumour suppressor p53 structure and drug discovery. LMB Division - Protein and Nucleic Acid Chemistry.

23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation.

23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status"

23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-02-06T11:14:05","modified_gmt":"2015-02-06T11:14:05","slug":"publications","status"

23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

23 Feb 2024: By contrast, overactivity of Bcl11a is known to cause lymphomas. One member of the Bcl11a network is p53, known to be important in controlling cell division and, when mutated, important in ... If p53 also is inactivated in mice that lack Bcl11a, some

23 Feb 2024: Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.

23 Feb 2024: P53 Epidemiological evidence to support a tax on Sugar Sweetened Drinks as a measure to address childhood obesity.

23 Feb 2024: and Denizot Y., 2012, Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin. ... Magnone V., Cogné M. and Denizot Y., 2011, A p53 defect sensitizes

23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the

23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

23 Feb 2024: Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

23 Feb 2024: p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma. Cancer Res.

25 Apr 2024: Simons. doi:10.1016/j.stem.2010.05.017. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

14 Aug 2023: For instance, adeno-viruses were programmed to couple their replication to the state of the p53 pathway in human cells93. ... Normal p53 production would result in inhibition of a crucial viral replication component, whereas a defunct p53 pathway, which

23 Feb 2024: P, Aden K.u00a0/spanEpithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.u00a0span class="docsum-journal-citation

23 Feb 2024: Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner” Mol Cell.

23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –.

14 Aug 2023: SYNBIOLOGY. An Analysis of Synthetic Biology Research in Europe and. North America. Final Report on Analysis of Synthetic Biology Sector. September 2006. Deliverable D11. FP6-2003-NEST-B4 Project 015357 – SYNBIOLOGY. European Commission 6th

14 Aug 2023: Complex and dynamic transcription regulation of mul-tiple genes and their pathways drives many essential cel-lular activities, including genome replication and repair, cell division and differentiation, and disease progression and inheritance.

14 Aug 2023: PRO. JECT. REP. ORT. EU. R 2. 1796. Synthetic BiologyApplying Engineering to Biology. Report of a NEST High-Level Expert Group. Interested in European research? RTD info is our quarterly magazine keeping you in touch with main developments (results,

14 Aug 2023: For example, researchers recently identified the production of multiple copies of p53, a gene known to inhibit cancer growth, in African elephants.

3 Apr 2024: Fischle, S.M. Gasserem. /em/p p(53)strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr / a

23 Feb 2024: Tweddle DA.<br /> p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma.<br /> Cancer Res.

14 Aug 2023: May 2020. The Bio Revolution: Innovations transforming econom. ies, societies, and our lives. The Bio RevolutionInnovations transforming economies, societies, and our lives. McKinsey Global Institute. Since its founding in 1990, the McKinsey Global

30 Apr 2024: Ras) and tumour suppression proteins (e.g. p53, p16/p19ARF or p21) (for review see Hynds et al., 2022; Wang et al., 2022).

23 Feb 2024: Cambridge Immunology Network - Department of Medicine https://www.immunology.cam.ac.uk/departments/medicine en Professor Ravindra Gupta https://www.immunology.cam.ac.uk/staff/professor-ravindra-gupta <div class="field field-name-field-sd-consultancy