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30 Apr 2024: We will also study how the test agent distributes itself around the body. ... Dosing will usually be daily, but this may vary depending upon the test agent.

30 Apr 2024: The inclusion of further detail to support why specific tests are most appropriate for the science. ... Further detail required in the Animal Experience section. • The inclusion of a timeline to show when the tests will be performed and at what stage

30 Apr 2024: These tests are animal equivalents of the measures that are used to assess pain in humans. ... Most of these tests mirror the tests used clinically to assess pain in humans.

30 Apr 2024: They will also identify test agents which are not suitable for further development. ... This expert regularly tests the tool against peer-reviewed power calculators and can adjust as necessary.

29 Apr 2024: This includes engineering tests (testing devices on the bench), computer models, and cell culture tests. ... The experimenter can make use of this to test devices aimed to restore similar deficits in patients.

29 Apr 2024: Blood samples will be taken after each vaccination to test for the induction of immune responses. ... There are no non-animal alternatives to conclusively test the immunogenicity and protection of vaccines.

30 Apr 2024: In this study, we will test potential treatments for Pelizaeus-Merzbacher disease, which currently has no cure. ... Behavior test: Assessment of cognitive, sensory and motor coordination might be done for mice developing phenotypes.

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... the action of test agents, and well as the variability in replicating the disease.

30 Apr 2024: Some mice will be used in experiments to test how the immune system responds to infections, inflammation and cancer. ... We considered using cells cultured and expanded in vitro to test whether certain molecular pathways have an important role in

30 Apr 2024: a disease state or other physiological state) and test agent levels from each animal. ... body, as well as monitoring how the test agent performs in an intact biological system.

30 Apr 2024: The majority of the data will be collected at the end of studies, where animals will be under deep terminal anaesthesia, in order to perform tests on how effective a test ... Giving a drug before injury can test its effect on bleeding and clot formation.

30 Apr 2024: Many of these behavioural tests will monitor the impact of pain on spontaneous behaviours, e.g. ... We also use non-interventional behavioural tests to measure the impact of pain conditions on an animal’s behaviour.

29 Apr 2024: To develop and validate animal models that can further our understanding of basic mechanisms involved in immunological disease and enable us to test new therapeutic agents. ... goal by enabling us to test new therapeutic hypothesis in vivo relevant to

30 Apr 2024: These are useful to test sensing mechanisms with a number of different assays. ... In this model, we can test nutrients or hormones and measure a number of metrics relevant to brain function.

30 Apr 2024: These tests showed that the devices work well in recording nerve activity and helping to control how nerves work. ... For example, we do a lot of computer simulations, which helps us test fewer things in living animals.

30 Apr 2024: What's the aim of this project? To fully test and understand how good platelets (blood cells that help stop bleeding) made from stem cells are at stopping bleeding. ... We are generating platelets from stem cells in the laboratory and need to test how

29 Apr 2024: This project will develop and test the safety and effectiveness of new vaccines against EHV induced disease. ... We typically use 7 animals per vaccine group, and we envisage we will test at least 2 candidate vaccines.

30 Apr 2024: This licence will enable us to test new treatments in mice and rats and predict how much to use in these models. ... Pharmacokinetic studies are usually not hypothesis testing in a statistical sense, so we do not test for a significant difference in

30 Apr 2024: rodent models to test how well they remain detectable and/or functional over a defined period of time. ... The information gathered here will inform us which drug is best suited to take forward to test in the target animal species.

30 Apr 2024: Typically, a mouse will experience each of these above procedures. Some animals will undergo 1, 2 or sometimes 3 behavioural tests typically to test motor skills, anxiety and spatial navigation. ... 3. Methods (test substances, quarantine and monitoring,