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1 - 50 of 55 search results for p53

  1. Fully-matching results

  2. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

  3. Home - Dr Rana's Group

    https://www.med.cam.ac.uk/rana/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling

  4. Publications - Professor Bennett's Group

    https://www.med.cam.ac.uk/bennett/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge.

  5. Featured Articles Archives - Page 14 of 32 - School of Clinical…

    https://www.medschl.cam.ac.uk/category/feature/page/14/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  6. Dr Mattia Frontini | Cambridge Cardiovascular

    https://www.cardiovascular.cam.ac.uk/directory/mfrontini
    23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

  7. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/pi/huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

  8. Research - Professor Marciniak's Group

    https://www.med.cam.ac.uk/marciniak/research/
    23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

  9. Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…

    https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/
    Thumbnail for Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular Biology 20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.

  10. Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen
    23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

  11. Publications - Kaser Group

    https://www.med.cam.ac.uk/kaser/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge.

  12. Publications

    https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/
    23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.

  13. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

  14. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

  15. Scheres lab

    https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html
    3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".

  16. spongistatin 1

    https://www-jmg.ch.cam.ac.uk/data/molecules/polyketides/spongistatin.html
    6 May 2024: s66;P5;P57;P53;P52;P50;P24;N8;s3;s76;d76;N15;s79;N17;N29;N24;s82;s84;d84;/rC:-.3572,3.7125,0;-.3572,2.8875,0;1.0717,2.

  17. Dr Ingo Ringshausen - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/
    23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

  18. School News Archives - Page 12 of 29 - School of Clinical Medicine

    https://www.medschl.cam.ac.uk/category/schoolnews/page/12/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  19. Publications - Dr Rana's Group

    https://www.med.cam.ac.uk/rana/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge.

  20. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

  21. Greta Skrupskelyte | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/great-skrupskelyte
    23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

  22. Publications - Professor Marciniak's Group

    https://www.med.cam.ac.uk/marciniak/publications/
    23 Feb 2024: p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.

  23. Research News Archives - Page 12 of 29 - School of Clinical Medicine

    https://www.medschl.cam.ac.uk/category/schoolnews/research-news/page/12/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  24. Dr Maria Christophorou | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/christophorou
    23 Feb 2024: She did her PhD with Gerard Evan at UCSF, where she was able to dissect the relative contributions of different p53 activating signals towards tumour suppression using mouse models of conditional ... p53 perturbation.

  25. https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/rana/wp-json/wp/v2/pages/26
    23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-01-12T14:44:42","modified_gmt":"2015-01-12T14:44:42","slug":"publications","status"

  26. Professor Alan Warren | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/warren
    23 Feb 2024: consequence of p53 stabilization in response to ribosomal stress.

  27. https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/bennett/wp-json/wp/v2/pages/26
    23 Feb 2024: {"id":26,"date":"2011-03-01T14:00:13","date_gmt":"2011-03-01T14:00:13","guid":{"rendered":"http://www.med.cam.ac.uk/infectious-diseases/?page_id=26"},"modified":"2015-02-06T11:14:05","modified_gmt":"2015-02-06T11:14:05","slug":"publications","status"

  28. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/brian-huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

  29. Professor Margaret Ashcroft | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/margaretashcroft
    23 Feb 2024: Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. ... Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell

  30. Dr Pentao Liu | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/pl2%40sanger.ac.uk
    23 Feb 2024: By contrast, overactivity of Bcl11a is known to cause lymphomas. One member of the Bcl11a network is p53, known to be important in controlling cell division and, when mutated, important in ... If p53 also is inactivated in mice that lack Bcl11a, some

  31. CBSB - Tissue bank and blood collection in Cambridge

    https://www.haem.cam.ac.uk/cambridge-blood-and-stem-cell-biobank/
    23 Feb 2024: Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.

  32. Catherine Perry - Department of Public Health and Primary Care

    https://www.phpc.cam.ac.uk/people/ceu-group/ceu-research-staff/catherine-perry/
    23 Feb 2024: P53 Epidemiological evidence to support a tax on Sugar Sweetened Drinks as a measure to address childhood obesity.

  33. Dr Rémi B. Fiancette | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/fiancette
    23 Feb 2024: and Denizot Y., 2012, Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/- mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin. ... Magnone V., Cogné M. and Denizot Y., 2011, A p53 defect sensitizes

  34. https://www.med.cam.ac.uk/marciniak/wp-json/wp/v2/pages/6

    https://www.med.cam.ac.uk/marciniak/wp-json/wp/v2/pages/6
    23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

  35. https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed

    https://www.cardiovascular.cam.ac.uk/taxonomy/term/8/feed
    23 Feb 2024: Cambridge Cardiovascular - Functional Genomics https://www.cardiovascular.cam.ac.uk/directory/research-themes/functional-genomics Functional Genomics theme led by Prof Nicole Soranzo performs epigenomic annotation of cells relevant to the

  36. Professor Alan J Warren - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/professor-alan-j-warren/
    23 Feb 2024: A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome.

  37. Dr El Kahina Meziane | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/ekm29%40cam.ac.uk
    23 Feb 2024: Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

  38. Dr Nunzio Iraci | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/dr-nunzio-iraci
    23 Feb 2024: p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma. Cancer Res.

  39. Publications: Biology

    www.tcm.phy.cam.ac.uk/~bds10/dir/publications_bio.html
    25 Apr 2024: Simons. doi:10.1016/j.stem.2010.05.017. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia.

  40. https://www.med.cam.ac.uk/kaser/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/kaser/wp-json/wp/v2/pages/26
    23 Feb 2024: P, Aden K.u00a0/spanEpithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.u00a0span class="docsum-journal-citation

  41. Professor Bertie Göttgens - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/professor-bertie-gottgens/
    23 Feb 2024: Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner” Mol Cell.

  42. Dr Andrew McKenzie | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/anm%40mrc-lmb.cam.ac.uk
    23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q. –.

  43. Chin

    https://www2.mrc-lmb.cam.ac.uk/ccsb/category/publications/feed/
    3 Apr 2024: Fischle, S.M. Gasserem. /em/p p(53)strongAcetylation of Lysine 120 of p53 endows DNA-binding Specificity at Effective Physiological Salt Concentration./strongbr / a

  44. https://www.immunology.cam.ac.uk/taxonomy/term/77/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/77/feed
    23 Feb 2024: Tweddle DA.<br /> p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma.<br /> Cancer Res.

  45. https://www.immunology.cam.ac.uk/taxonomy/term/57/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/57/feed
    23 Feb 2024: Cambridge Immunology Network - Department of Medicine https://www.immunology.cam.ac.uk/departments/medicine en Professor Ravindra Gupta https://www.immunology.cam.ac.uk/staff/professor-ravindra-gupta <div class="field field-name-field-sd-consultancy

  46. https://www.immunology.cam.ac.uk/taxonomy/term/7/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/7/feed
    23 Feb 2024: Cambridge Immunology Network - Autoimmunity and inflammation https://www.immunology.cam.ac.uk/Networkdirectory/research-themes/autoimmunity-inflammation Investigating the causes of excessive and aberrant immune responses which result in inflammation

  47. https://www.immunology.cam.ac.uk/taxonomy/term/59/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/59/feed
    23 Feb 2024: Cambridge Immunology Network - MRC Laboratory of Molecular Biology https://www.immunology.cam.ac.uk/departments/mrc-lmb en Conor O'Donovan https://www.immunology.cam.ac.uk/staff/conor-odonovan <div class="field field-name-field-sd-consultancy

  48. https://www.med.cam.ac.uk/marciniak/wp-json/wp/v2/pages/26

    https://www.med.cam.ac.uk/marciniak/wp-json/wp/v2/pages/26
    23 Feb 2024: Br J Cancer. 2013 Apr 2;108(6):1340-7. doi: 10.1038/bjc.2013.66./pnpa href="http://www.ncbi.nlm.nih.gov/pubmed/23341460"p53 and translation attenuation regulate

  49. https://www.immunology.cam.ac.uk/taxonomy/term/13/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/13/feed
    23 Feb 2024: Cambridge Immunology Network - Molecular and structural immunology https://www.immunology.cam.ac.uk/Networkdirectory/research-themes/molecular-structural-immunology Molecular and structural techniques are used to address a wide range of

  50. https://www.immunology.cam.ac.uk/taxonomy/term/44/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/44/feed
    23 Feb 2024: Tweddle DA.<br /> p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma.<br /> Cancer Res.

  51. https://www.immunology.cam.ac.uk/taxonomy/term/25/feed

    https://www.immunology.cam.ac.uk/taxonomy/term/25/feed
    23 Feb 2024: and McKenzie, A.N.J. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q<sup>–</sup> syndrome.

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