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1 - 20 of 52 search results for p53

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  2. Therapeutic vulnerabilities in lung tumours with distinct p53…

    https://www.medschl.cam.ac.uk/therapeutic-vulnerabilities-lung-tumours-distinct-p53-deficiencies/
    23 Feb 2024: School of Clinical Medicine. Featured Articles. Therapeutic vulnerabilities in lung tumours with distinct p53 deficiencies. ... Importantly, the authors identified a similar p53-mutation type specific gene expression signature in human lung tumors.

  3. Home - Dr Rana's Group

    https://www.med.cam.ac.uk/rana/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Dr Rana's Group. Welcome to Rana Lab. Research. The role of TGF-beta superfamily signalling

  4. Publications - Professor Bennett's Group

    https://www.med.cam.ac.uk/bennett/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Professor Bennett's Group. Publications. Links. 2024 University of Cambridge.

  5. Featured Articles Archives - Page 14 of 32 - School of Clinical…

    https://www.medschl.cam.ac.uk/category/feature/page/14/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  6. Dr Mattia Frontini | Cambridge Cardiovascular

    https://www.cardiovascular.cam.ac.uk/directory/mfrontini
    23 Feb 2024: Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. ... CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

  7. Professor Brian Huntly | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/pi/huntly
    23 Feb 2024: In association with an alteration of the DNA damage response mediated through suboptimal Crebbp acetylation of p53, DNA double strand breaks accumulate and accompanied by a relative decrease in apoptosis, lead

  8. Research - Professor Marciniak's Group

    https://www.med.cam.ac.uk/marciniak/research/
    23 Feb 2024: Marciniak. 2013. p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress.

  9. Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular…

    https://www2.mrc-lmb.cam.ac.uk/research/protein-and-nucleic-acid-chemistry/
    Thumbnail for Protein and Nucleic Acid Chemistry - MRC Laboratory of Molecular Biology 20 May 2024: Alan Fersht - Tumour suppressor p53 structure and drug discovery.

  10. Ingo Ringshausen | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/ingo-ringshausen
    23 Feb 2024: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Cancer Cell, 2006. 10(6): p. 501-14 PMID:17157790. Christophorou MA, Ringshausen I, Finch AJ, Swigart LB, Evan GI The pathological response to DNA damage does not

  11. Publications - Kaser Group

    https://www.med.cam.ac.uk/kaser/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Kaser Group. Publications. Reviews & Editorials. 2024 University of Cambridge.

  12. Publications

    https://www-neurosciences.medschl.cam.ac.uk/horvathlab/publications/
    23 Feb 2024: RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.

  13. Florian T. Merkle - Institute of Metabolic Science-Metabolic Research …

    https://www.mrl.ims.cam.ac.uk/research/principal-investigators/florian-t-merkle/
    23 Feb 2024: For example, hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation from transplanted cells (Merkle ... Human pluripotent stem cells

  14. Dr Suzanne Dawn Turner | Cambridge Immunology Network

    https://www.immunology.cam.ac.uk/Networkdirectory/sdturner
    23 Feb 2024: 2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing ... Merkel, O., Morrigl, R.,Turner, S.D. and Kenner, L. (2017) When the

  15. Scheres lab

    https://www2.mrc-lmb.cam.ac.uk/groups/scheres/publications.html
    3 May 2024: Valle (2011) "Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA".

  16. spongistatin 1

    https://www-jmg.ch.cam.ac.uk/data/molecules/polyketides/spongistatin.html
    6 May 2024: s66;P5;P57;P53;P52;P50;P24;N8;s3;s76;d76;N15;s79;N17;N29;N24;s82;s84;d84;/rC:-.3572,3.7125,0;-.3572,2.8875,0;1.0717,2.

  17. Dr Ingo Ringshausen - Department of Haematology

    https://www.haem.cam.ac.uk/staff/senior-staff/dr-ingo-ringshausen/
    23 Feb 2024: Swigart, and G.I. Evan. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. ... Finch, L.B. Swigart, and G.I. Evan. Thepathological response to DNA damage does not contribute to p53-mediated tumour suppression.

  18. School News Archives - Page 12 of 29 - School of Clinical Medicine

    https://www.medschl.cam.ac.uk/category/schoolnews/page/12/
    23 Feb 2024: Approximately half of lung adenocarcinomas, the most common type of lung cancer, harbor mutations in a gene called TP53(p53), a key player in the body’s in-built defence mechanism

  19. Publications - Dr Rana's Group

    https://www.med.cam.ac.uk/rana/publications/
    23 Feb 2024: Quick Links. For staff. For alumni. For business. Colleges & departments. Libraries & facilities. Museums & collections. Email & phone search. Search site. Publications. Dr Rana's Group. Publications. 2024 University of Cambridge.

  20. Dr Florian Merkle | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/people/affiliates/merkle
    23 Feb 2024: For example, we recently showed that hPSCs recurrently acquire cancer-associated mutations in the tumour suppressor TP53 (p53) that promote growth in culture and would increase the risk of cancer formation

  21. Greta Skrupskelyte | Wellcome-MRC Cambridge Stem Cell Institute

    https://www.stemcells.cam.ac.uk/directory/great-skrupskelyte
    23 Feb 2024: 2018) Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

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