Search

30 Apr 2024: Both are important immunological processes and targets for the development of new drugs. ... There is a great unmet clinical need in this area and our experiments could inform the development of new therapeutics.

30 Apr 2024: We are following this research field closely and will replace animal research where we can as new technologies develop and are tested and established. ... We also discuss with other groups doing similar research and have an open policy whereby new

30 Apr 2024: They enable us to test the effect of new treatments in a relevant and intact biological system. ... This project will provide important information to progress new treatments through the phases of drug development.

30 Apr 2024: The outputs of this licence will likely result in a new information and publications of the following:. ... With this knowledge gained we can identify new testable pathways for augmenting regeneration.

30 Apr 2024: Monoclonal antibodies are expected to become a new standard of care in veterinary medicine. ... In order to predict protein structures and design new proteins, large language models (LLMs) are used.

30 Apr 2024: This project will generate important data in the preclinical development of potential new drugs for metabolic and cardiovascular disease. ... This will include investigation of any potential unwanted side effects that could be caused by the new drugs.

30 Apr 2024: We hope that this will help us develop new treatments for diseases that are caused by problems with myelin. ... Other enrichments like tunnels, climbing structures, and new objects can be added to encourage natural behavior.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: Also, these devices will help us learn more about these diseases and might help find even more new treatments. ... Subscribing to the NC3Rs newsletter (https://www.nc3rs.org.uk/news) to receive regular updates on new ideas and research related to the 3Rs.

30 Apr 2024: Results will open avenues to developing new therapies to treat pain and neurodegeneration. ... Have regular discussions with the Named Persons and animal technicians within the facility to review current approaches and whether there are any new 3Rs

30 Apr 2024: In new systems pilot studies are utilised to ensure the system works as intended with a small group (e.g. ... Mice would also be habitualised to a new restraint before, e.g., BP measurement.

30 Apr 2024: 1. New mouse models of mitochondrial disease which carry mutations similar to those found in humans. ... The remaining 20% will be neonates (new born pups up to weaning - approx.

30 Apr 2024: Some of these methods are aimed at providing information to develop new therapies for these diseases. ... We are developing new ways to image cancer and inflammation and find novel ways of treating these diseases.

30 Apr 2024: We will make a new generation for each line every year (5 generations per line). ... In addition, when generating new genetically modified lines, the F0 embryos need to be genotypically screened.

30 Apr 2024: If the pilot experiment raises unexpected new questions, a subsequent pilot experiment will be performed. ... We will routinely check the NC3R's resource library and keep abreast with, and implement where appropriate, any new advances in refinement,

30 Apr 2024: suffer from traumatic brain injuries and 14 million new incidents of stroke globally, each year. ... may require the generation of new transgenic animals, therefore reducing the number of animals needed to fulfil the objectives we set up in this license.

30 Apr 2024: There is no cure for neurodegenerative disorders and thus, finding a new common target is at utmost importance. ... We have created new mouse lines with specific mutations in genes that disrupt one of the stress response pathway that is called

30 Apr 2024: There is an urgent need for new drugs and therapies to slow, delay and prevent proteinopathy diseases. ... Overall, we hope to identify new genes and compounds that allow us to better understand and manipulate neurodegeneration.

30 Apr 2024: This project will provide important information that aids the progression of new drugs against bleeding disorders through the drug discovery and development process. ... for our studies and to identify any new and better methods that could be utilised.

30 Apr 2024: benefit people living with mental health disorders through the development of new treatments. ... We also expect, in the medium term, that our research will lead to the development of new behavioural treatments.

30 Apr 2024: Ultimately, this project will contribute to the successful development of new drugs, which will benefit patients with the diseases being treated. ... make use of any new knowledge or better methods of performing animal studies.

30 Apr 2024: In the long-term we hope that this work will lead to translational outputs in the form of clinical trials around new therapeutic agents. ... establishing a new colony of mice from frozen eggs and/or sperm) any further strains of mice we need for this

30 Apr 2024: These new discoveries will be shared with others at local, national and international scientific meetings and in widely available publications. ... In more detail, it is our expectation that our research will produce one new.

30 Apr 2024: Therefore there is a clear need to pioneer new medical treatments and technologies to address this increasing disease burden. ... This will inform specific drug projects that are aiming to produce new medicines for patients.

30 Apr 2024: Ultimately, the intention is that this research will lead to new treatments being developed for mood, anxiety and stress-related mental health disorders. ... benefit people living with mental health disorders through the development of new treatments.

30 Apr 2024: However, the underlying reasons (which could offer new therapies) are only partially understood. ... might be doing regarding animal research and ensure our methods stay updated within the new refinements implemented by others.

30 Apr 2024: We have chosen to work with a new world monkey, the common marmoset. ... When we embark on a new study we tend to start off with 2 lead animals in which we test out our hypothesis.

30 Apr 2024: memory symptoms, guiding new treatment strategies as well as providing insight into the mechanisms by which current therapies have their efficacious actions. ... When I embark on a new study, I start off with 2 lead animals in.

30 Apr 2024: Therefore, the proposed work in this new project licence may hasten translation to relatively simple but novel human clinical interventions to not only treat the mother, but also her progeny. ... Therefore, the project licence holder will have regular

30 Apr 2024: Knowledge generated from this work will open new avenues to eradicate whipworm and hookworm infections and control immune-mediated diseases. ... By the end of this project, we will have new information on the host-whipworm relationship, including (1) how

30 Apr 2024: We will incorporate new recommendations on animal rearing and welfare as we have done up to now. ... We stay up-to-date with new information and new resources as they become available.

30 Apr 2024: For example, understanding how cell identity can contribute to diseases may help in the discovery of new treatments. ... I am currently on the European Xenopus Resource Steering Committee where new developments in frog husbandry are often discussed.

30 Apr 2024: Human embryos are highly inaccessible for research. We use animals to test new experimental approaches, and the knowledge gained can be used to investigate similar events in precious human fetuses and ... We have reduced significantly the number of mice

30 Apr 2024: By disseminating our observations from early stages, for example via conferences, we create new collaborations with experts in research fields beyond our own. ... We will carry out pilot studies when new substances, radiation doses, or genetically

30 Apr 2024: We will generate new insight into the major biological processes underlying inflammatory diseases. ... This enables the development of new therapeutics, exploiting our discoveries. Species and numbers of animals expected to be used.

30 Apr 2024: until we require new offspring. ... I will also have regular discussions with the Named Persons and animal technicians to review current approaches and whether there are any new 3R opportunities.

30 Apr 2024: Furthermore, we have an extensive tissue bank of samples that can be utilised prior to generating new animal cohorts. ... Our group will attend termly facility user committee meetings where new information is disseminated.

30 Apr 2024: As new molecular targets involved in diseases are discovered, the imaging agents that are required for imaging them need to be developed and evaluated in a manner similar to the drug ... When new drugs for removing these proteins are being developed it